Early Iipopolysaccharide-induced reactive oxygen species production evokes necrotic cell death in human umbilical vein endothelial cells

Journal of Hypertension

Volumn 27, Issue 6, 2009, Pages 1202-1216

  Simon, Felipe ^a   Fernández, Ricardo ^a  

^a UNIVERSIDAD ANDRÉS BELLO   (Chile)

Author keywords

Endothelial cells; Lipopolysaccharide; NAD(P)H oxidase; Necrosis; Reactive oxygen species

Indexed keywords

LIPOPOLYSACCHARIDE; PHOSPHOLIPASE C; PROTEIN KINASE C; PROTEIN P47; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; TOLL LIKE RECEPTOR 4; CYBB PROTEIN, HUMAN; CYTOKINE; MEMBRANE PROTEIN; NOX4 PROTEIN, HUMAN; PHOSPHATIDYLINOSITOL 3 KINASE; PRIMER DNA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SMALL INTERFERING RNA; TLR4 PROTEIN, HUMAN;

ARTICLE; CELL COUNT; CELL DEATH; CELL VIABILITY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENDOTHELIUM CELL; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UMBILICAL VEIN; WESTERN BLOTTING; BIOLOGICAL MODEL; CELL CULTURE; CELL SURVIVAL; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; METABOLISM; NECROSIS; NUCLEOTIDE SEQUENCE; PATHOLOGY;

1-PHOSPHATIDYLINOSITOL 3-KINASE; BASE SEQUENCE; CELL SURVIVAL; CELLS, CULTURED; CYTOKINES; DNA PRIMERS; ENDOTHELIAL CELLS; HUMANS; LIPOPOLYSACCHARIDES; MEMBRANE GLYCOPROTEINS; MODELS, BIOLOGICAL; NADPH OXIDASE; NECROSIS; PROTEIN KINASE C; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4; TYPE C PHOSPHOLIPASES;

EID: 67649777080     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/HJH.0b013e328329e31c     Document Type: Article

References (67)

1. Cai H, Harrison DG. Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ Res 2000; 87:840-844.
2. Dauphinee SM, Karsan A. Lipopolysaccharide signaling in endothelial cells. Lab Invest 2006; 86:9-22.
3. Suematsu M, Suzuki H, Delano FA, Schmid-Schonbein GW. The inflammatory aspect of the microcirculation in hypertension: oxidative stress, leukocytes/endothelial interaction, apoptosis. Microcirculation 2002; 9:259-276.
4. Korthuis RJ, Anderson DC, Granger DN. Role of neutrophil-endothelial cell adhesion in inflammatory disorders. J Crit Care 1994; 9:47-71.
5. Simon F, Varela D, Eguiguren AL, Diaz LF, Sala F, Stutzin A. Hydroxyl radical activation of a Ca(2+)-sensitive nonselective cation channel involved in epithelial cell necrosis. Am J Physiol Cell Physiol 2004; 287:C963-C970.
6. Simon F, Varela D, Riveras A, Eguiguren AL, Stutzin A. Nonselective cation channels and oxidative stress-induced cell swelling. Biol Res 2002; 35:215-222.
7. Pinsky MR. Dysregulation of the immune response in severe sepsis. Am J Med Sci 2004; 328:220-229.
8. Schletter J, Heine H, Ulmer AJ, Rietschel ET. Molecular mechanisms of endotoxin activity. Arch Microbiol 1995; 164:383-389.
9. Ulevitch RJ, Tobias PS. Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin. Annu Rev Immunol 1995; 13:437-457.
10. Akira S. Toll-like receptor signaling. J Biol Chem 2003; 278:38105-38108.
11. Medvedev AE, Kopydlowski KM, Vogel SN. Inhibition of lipopolysaccharide- induced signal transduction in endotoxin-tolerized mouse macrophages: dysregulation of cytokine, chemokine, and toll-like receptor 2 and 4 gene expression. J Immunol 2000; 164:5564-5574.
12. Sanlioglu S, Williams CM, Samavati L, Butler NS, Wang G, McCray PB Jr, et al. Lipopolysaccharide induces Rac1 -dependent reactive oxygen species formation and coordinates tumor necrosis factor-alpha secretion through IKK regulation of NF-kappa B. J Biol Chem 2001; 276:301 88-30198.
13. Boxer GJ, Curnutte JT, Boxer LA. Polymorphonuclear leukocyte function. Hosp Pract (Off Ed) 1985; 20:69-73; 77, 80.
14. Gougerot-Podicalo MA, Elbim C, Chollet-Martin S. Modulation of the oxidative burst of human neutrophils by pro- and anti-inflammatory cytokines. Pathol Biol (Paris) 1996; 44:36-41.
15. DeLeo FR, Renee J, McCormick S, Nakamura M, Apicella M, Weiss JP, et al. Neutrophils exposed to bacterial lipopolysaccharide upregulate NADPH oxidase assembly. J Clin Invest 1998; 101:455-463.
16. Babior BM. NADPH oxidase. Curr Opin Immunol 2004; 16:42-47.
17. El Benna J, Faust LP, Babior BM. The phosphorylation of the respiratory burst oxidase component p47phox during neutrophil activation. Phosphorylation of sites recognized by protein kinase C and by proline-directed kinases. J Biol Chem 1 994; 269:23431-23436.
18. Faure E, Equils O, Sieling PA, Thomas L, Zhang FX, Kirschning CJ, et al. Bacterial lipopolysaccharide activates NF-kappaB through toll-like receptor 4 (TLR-4) in cultured human dermal endothelial cells. Differential expression of TLR-4 and TLR-2 in endothelial cells. J Biol Chem 2000; 275:11058-11063.
19. Mantovani A, Bussolino F, Dejana E. Cytokine regulation of endothelial cell function. FASEB J 1 992; 6:2591-2599.
20. Frey RS, Rahman A, Kefer JC, Minshall RD, Malik AB. PKCzeta regulates TNF-alpha-induced activation of NADPH oxidase in endothelial cells. Circ Res 2002; 90:1012-1019.
21. Park HS, Chun JN, Jung HY, Choi C, Bae YS. Role of NADPH oxidase 4 in lipopolysaccharide-induced proinflammatory responses by human aortic endothelial cells. Cardiovasc Res 2006; 72:447-455.
22. Imaizumi T, Itaya H, Fujita K, Kudoh D, Kudoh S, Mori K, et al. Expression of tumor necrosis factor-alpha in cultured human endothelial cells stimulated with lipopolysaccharide or interleukin-1 alpha. Arterioscler Thromb Vasc Biol 2000; 20:410-415.
23. Burvall K, Palmberg L, Larsson K. Expression of TNFalpha and its receptors R1 and R2 in human alveolar epithelial cells exposed to organic dust and the effects of 8-bromo-cAMP and protein kinase A modulation. Inflamm Res 2005; 54:281-288.
24. Naumann M, Wessler S, Bartsch C, Wieland B, Meyer TF. Neisseria gonorrhoeae epithelial cell interaction leads to the activation of the transcription factors nuclear factor kappaB and activator protein 1 and the induction of inflammatory cytokines. J Exp Med 1997; 186:247-258.
25. Hirata T, Osuga Y, Hirota Y, Koga K, Yoshino O, Harada M, et al. Evidence for the presence of toll-like receptor 4 system in the human endometrium. J Clin Endocrinol Metab 2005; 90:548-556.
26. Cheng G, Cao Z, Xu X, van Meir EG, Lambeth JD. Homologsof gp91 phox: cloning and tissue expression of Nox3, Nox4, and Nox5. Gene 2001; 269:131-140.
27. Pedruzzi E, Guichard C, Ollivier V, Driss F, Fay M, Prunet C, et al. NAD(P)H oxidase Nox-4 mediates 7-ketocholesterol-induced endoplasmic reticulum stress and apoptosis in human aortic smooth muscle cells. Mol Cell Biol 2004; 24:10703-10717.
28. Kim YM, Guzik TJ, Zhang YH, Zhang MH, Kattach H, Ratnatunga C, et al. A myocardial Nox2 containing NAD(P)H oxidase contributes to oxidative stress in human atrial fibrillation. Circ Res 2005; 97:629-636.
29. Valencia A, Kochevar IE. Nox1 -based NADPH oxidase is the major source of UVA-induced reactive oxygen species in human keratinocytes. J Invest Dermatol 2008; 128:214-222.
30. Ikeda S, Yamaoka-Tojo M, Hilenski L, Patrushev NA, Anwar GM, Quinn MT, et al. IQGAP1 regulates reactive oxygen species-dependent endothelial cell migration through interacting with Nox2. Arterioscler Thromb Vasc Biol 2005; 25:2295-2300.
31. Maranchie JK, Zhan Y. Nox4 is critical for hypoxia-inducible factor 2-alpha transcriptional activity in von Hippel-Lindau-deficient renal cell carcinoma. Cancer Res 2005; 65:91 90-91 93.
32. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 1983; 65:55-63.
33. Hetz C, Bono MR, Barros LF, Lagos R. Microcin E492, a channel-forming bacteriocin from Klebsiella pneumoniae, induces apoptosis in some human cell lines. Proc Natl Acad Sci U S A 2002; 99:2696-2701.
34. Traenckner EB, Pahl HL, Henkel T, Schmidt KN, Wilk S, Baeuerle PA. Phosphorylation of human I kappa B-alpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuli. EMBO J 1995; 14:2876-2883.
35. 2 generation and cell proliferation in human umbilical vein endothelial cells. Endothelium 2008; 15:175-188.
36. Hwang J, Kleinhenz DJ, Lassegue B, Griendling KK, Dikalov S, Hart CM. Peroxisome proliferator-activated receptor-gamma ligands regulate endothelial membrane superoxide production. Am J Physiol Cell Physiol 2005; 288:C899-C905.
37. Paik YH, Schwabe RF, Bataller R, Russo MP, Jobin C, Brenner DA. Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells. Hepatology 2003; 37:1043-1055.
38. Basak C, Pathak SK, Bhattacharyya A, Mandal D, Pathak S, Kundu M. NF-kappaB- and C/EBPbeta-driven interleukin-1 beta gene expression and PAK1-mediated caspase-1 activation play essential roles in interleukin- 1 beta release from Helicobacter pylori lipopolysaccharide-stimulated macrophages. J Biol Chem 2005; 280:4279-4288.
39. El Benna J, Faust RP, Johnson JL, Babior BM. Phosphorylation of the respiratory burst oxidase subunit p47phox as determined by two-dimensional phosphopeptide mapping. Phosphorylation by protein kinase C, protein kinase A, and a mitogen-activated protein kinase. J Biol Chem 1996; 271:6374-6378.
40. Park JW, Babior BM. Activation of the leukocyte NADPH oxidase subunit p47phox by protein kinase C. A phosphorylation-dependent change in the conformation of the C-terminal end of p47phox. Biochemistry 1997; 36:7474-7480.
41. Lopes LR, Hoyal CR, Knaus UG, Babior BM. Activation of the leukocyte NADPH oxidase by protein kinase C in a partially recombinant cell-free system. J Biol Chem 1999; 274:15533-15537.
42. Bae YS, Sung JY, Kim OS, Kim YJ, Hur KC, Kazlauskas A, et al. Platelet-derived growth factor-induced H(2)O(2) production requires the activation of phosphatidylinositol 3-kinase. J Biol Chem 2000; 275:10527-10531.
43. Koedel U, Pfister HW. Superoxide production by primary rat cerebral endothelial cells in response to pneumococci. J Neuroimmunol 1999; 96:190-200.
44. Volk T, Kox WJ. Endothelium function in sepsis. Inflamm Res 2000; 49:185-198.
45. Sorescu D, Weiss D, Lassegue B, Clempus RE, Szocs K, Sorescu GP, et al. Superoxide production and expression of nox family proteins in human atherosclerosis. Circulation 2002; 105:1429-1435.
46. Yokoyama M, Inoue N, Kawashima S. Role of the vascular NADH/NADPH oxidase system in atherosclerosis. Ann N Y Acad Sci 2000; 902:241-247.
47. Morawietz H, Weber M, Rueckschloss U, Lauer N, Hacker A, Kojda G. Upregulation of vascular NAD(P)H oxidase subunit gp91 phox and impairment of the nitric oxide signal transduction pathway in hypertension. Biochem Biophys Res Commun 2001; 285:1130-1135.
48. Guzik TJ, Mussa S, Gastaldi D, Sadowski J, Ratnatunga C, Pillai R, et al. Mechanisms of increased vascular superoxide production in human diabetes mellitus: role of NAD(P)H oxidase and endothelial nitric oxide synthase. Circulation 2002; 105:1656-1662.
49. Hampton MB, Kettle AJ, Winterbourn CC. Inside the neutrophil phagosome: Oxidants, myeloperoxidase, and bacterial killing. Blood 1 998; 92:3007-3017.
50. Winterbourn CC, Vissers MC, Kettle AJ. Myeloperoxidase. Curr Opin Hematol 2000; 7:53-58.
51. Virag L, Szabo E, Gergely P, Szabo C. Peroxynitrite-induced cytotoxicity: mechanism and opportunities for intervention. Toxicol Lett 2003; 140-141:113-124.
52. Bonfoco E, Krainc D, Ankarcrona M, Nicotera P, Lipton SA. Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures. Proc Natl Acad Sci U S A 1995; 92:7162-7166.
53. Buvinic S, Huidobro-Toro JP. Basal tonic release of nitric oxide coupled to cGMP production regulates the vascular reactivity of the mesenteric bed. Eur J Pharmacol 2001; 424:221-227.
54. Jacobi J, Kristal B, Chezar J, Shaul SM, Sela S. Exogenous superoxide mediates pro-oxidative, proinflammatory, and procoagulatory changes in primary endothelial cell cultures. Free Radic Biol Med 2005; 39:1238-1248.
55. Wu F, Schuster DP, Tyml K, Wilson JX. Ascorbate inhibits NADPH oxidase subunit p47phox expression in microvascular endothelial cells. Free Radic Biol Med 2007; 42:124-131.
56. Gu Y, Xu YC, Wu RF, Souza RF, Nwariaku FE, Terada LS. TNFalpha activates c-Jun amino terminal kinase through p47(phox). Exp Cell Res 2002; 272:62-74.
57. Wu RF, Gu Y, Xu YC, Nwariaku FE, Terada LS. Vascular endothelial growth factor causes translocation of p47phox to membrane ruffles through WAVE1. J Biol Chem 2003; 278:36830-36840.
58. Sossey-Alaoui K, Li X, Ranalli TA, Cowell JK. WAVE3-mediated cell migration and lamellipodia formation are regulated downstream of phosphatidylinositol 3-kinase. J Biol Chem 2005; 280:21 748-21 755.
59. liyama M, Kakihana K, Kurosu T, Miura O. Reactive oxygen species generated by hematopoietic cytokines play roles in activation of receptor-mediated signaling and in cell cycle progression. Cell Signal 2006; 18:174-182.
60. Mookerjee BJ, Mookerjee A, Sen P, Bhaumik S, Sen P, Banerjee S, et al. Sodium antimony gluconate induces generation of reactive oxygen species and nitric oxide via phosphoinositide 3-kinase and mitogen-activated protein kinase activation in Leishmania donovani-infected macrophages. Antimicrob Agents Chemother 2006; 50:1 788-1 797.
61. Frank GD, Saito S, Motley ED, Sasaki T, Ohba M, Kuroki T, et al. Requirement of Ca(2+) and PKCdelta for Janus kinase 2 activation by angiotensin II: involvement of PYK2. Mol Endocrinol 2002; 16:367-377.
62. Grandage VL, Everington T, Linch DC, Khwaja A. Go6976 is a potent inhibitor of the JAK 2 and FLT3 tyrosine kinases with significant activity in primary acute myeloid leukaemia cells. Br J Haematol 2006; 135:303-316.
63. Salonen T, Sareila O, Jalonen U, Kankaanranta H, Tuominen R, Moilanen E. Inhibition of classical PKC isoenzymes downregulates STAT1 activation and iNOS expression in LPS-treated murine J774 macrophages. Br J Pharmacol 2006; 147:790-799.
64. Li AE, Ito H, Rovira II, Kim KS, Takeda K, Yu ZY, et al. A role for reactive oxygen species in endothelial cell anoikis. Circ Res 1999; 85:304-310.
65. Buttke TM, Sandstrom PA. Oxidative stress as a mediator of apoptosis. Immunol Today 1994; 15:7-10.
66. Byun HS, Won M, Park KA, Kim YR, Choi BL, Lee H, et al. Prevention of TNF-induced necrotic cell death by rottlerin through a Nox1 NADPH oxidase. Exp Mol Med 2008; 40:186-195.
67. Kim YS, Morgan MJ, Choksi S, Liu ZG. TNF-induced activation of the Nox1 NADPH oxidase and its role in the induction of necrotic cell death. Mol Cell 2007; 26:675-687.