The Chinese hamster dihydrofolate reductase replication origin beta is active at multiple ectopic chromosomal locations and requires specific DNA sequence elements for activity

Molecular and Cellular Biology

Volumn 21, Issue 4, 2001, Pages 1098-1110

  Altman, A L ^a   Fanning, E ^a  

^a VANDERBILT UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIHYDROFOLATE REDUCTASE; DNA;

ANIMAL CELL; ARTICLE; CHO CELL; CHROMOSOMAL LOCALIZATION; DELETION MUTANT; DNA REPLICATION; DNA SEQUENCE; GENETIC TRANSFECTION; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

ANIMALS; BASE SEQUENCE; CHO CELLS; CHROMOSOMES; CRICETINAE; CRICETULUS; DNA PRIMERS; DNA REPLICATION; REPLICATION ORIGIN; TETRAHYDROFOLATE DEHYDROGENASE; TRANSFECTION;

EID: 0035146622     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.21.4.1098-1110.2001     Document Type: Article

References (90)

1. Cell cycle modulation of protein-DNA interactions at a human replication origin
2. Start sites of bidirectional DNA synthesis at the human lamin B2 origin
3. Participation of the human β-globin locus control region in initiation of DNA replication
4. Genetic dissection of a mammalian replicator in the human β-globin locus
5. Replication in the amplified dihydrofolate reductase domain in CHO cells may initiate at two distinct sites, one of which is a repetitive sequence element
6. Drosophila ORC specifically binds to ACE3, an origin of DNA replication control element
7. Unusual sequence element found at the end of an amplicon
8. Sequence requirements for the stimulation of gene amplification by a mammalian genomic element
9. ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex
10. Discrete start sites for DNA synthesis in the yeast ARS1 origin
11. Chromosomal ARS1 has a single leading strand start site
12. Initiation of eukaryotic DNA replication: Conservative or liberal?
13. Initiation at closely spaced replication origins in a yeast chromosome
14. Identification of an origin of bidirectional replication in mammalian chromosomes
15. RIP60, a mammalian origin-binding protein, enhances DNA bending near the dihydrofolate reductase origin of replication
16. Intramolecular DNA triplexes, bent DNA and DNA unwinding elements in the initiation region of an amplified dihydrofolate reductase replicon
17. Changes in gene position are accompanied by a change in time of replication
18. The fission yeast homologue of Orc4p binds to replication origin DNA via multiple AT-hooks
19. Genetic analysis of an ARS element from the fission yeast Schizosaccharomyces pombe
20. Critical spatial requirement within the origin of simian virus 40 DNA replication
21. Purification of RIP60 and RIP100, mammalian proteins with origin-specific DNA-binding and ATP-dependent DNA helicase activities
22. Origins of DNA replication that function in eukaryotic cells
23. Origins of DNA replication
24. Replication origins in metazoan chromosomes: Fact or fiction?
25. Selection of homeotic proteins for binding to a human DNA replication origin
26. The Chinese hamster dihydrofolate reductase origin consists of multiple potential nascent-strand start sites
27. Sequence and context effects on origin function in mammalian cells
28. Replication initiation sites are distributed widely in the amplified CHO dihydrofolate reductase domain
29. In vivo protein-DNA interactions at a human DNA replication origin
30. The spatial position and replication timing of chromosomal domains are both established in early G1 phase
31. A novel procedure for quantitative polymerase chain reaction by coamplification of competitive templates
32. Initiation of DNA replication in eukaryotic cells
33. Evidence that a single replication fork proceeds from early to late replicating domains in the IgH locus in a non-B cell line
34. A position effect on the time of replication orign activation in yeast
35. Patterns of integration of DNA microinjected into cultured mammalian cells: Evidence for homologous recombination between injected plasmid DNA molecules
36. Multiple determinants controlling activation of yeast replication origins in late S phase
37. Localization and DNA sequence of a replication origin in the rhodopsin gene locus of Chinese hamster cells
38. Replication initiation point mapping
39. Fine mapping of a replication origin of human DNA
40. Replication origins in yeast versus metazoa: Separation of the haves and have nots
41. Initiation of replication in the Chinese hamster dihydrofolate reductase domain
42. Mapping replication units in animal cells
43. An amplified chromosomal sequence that includes the gene for dihydrofolate reductase initiates replication within specific restriction fragment
44. Cloning of the initiation region of a mammalian chromosomal replicon
45. The dhfr ori beta-binding protein RIP60 contains 15 zinc fingers: DNA binding and looping by the central three fingers and an associated proline-rich region
46. On the regulation of DNA replication in bacteria
47. Non-random deletions at the dihydrofolate reductase locus of Chinese hamster ovary cells induced by α-particle stimulating radon
48. Replication of a plasmid bearing a human Alu-family repeat in monkey COS-7 cells
49. Distal sequences, but not ori-beta/OBR-1, are essential for initiation of DNA replication in the Chinese hamster DHFR origin
50. Multiple orientation-dependent, synergistically interacting, similar domains in the ribosomal DNA replication origin of the fission yeast, Schizosaccharomyces pombe
51. Influence of a replication enhancer on the hierarchy of origin efficiencies within a cluster of DNA replication origins
52. Identification of primary initiation sites for DNA replication in the hamster dihydrofolate reductase gene initiation zone
53. Utilization of the same DNA replication origin by human cells of different derivation
54. Opposite replication polarity of the germ line c-myc gene in HeLa cells compared with that of two Burkitt lymphoma cell lines
55. High-resolution mapping of replication fork movement through the amplified dihydrofolate reductase domain in CHO cells by in-gel renaturation analysis
56. Activation of a mammalian origin of replication by chromosomal rearrangement
57. Selective activation of pre-replication complexes in vitro at specific sites in mammalian nuclei
58. Isolation of ORC6, a component of the yeast origin recognition complex by a one-hybrid system
59. Initiation and termination of DNA replication in human rRNA genes
60. A transcriptional insulator element, the su(Hw) binding site, protects a chromosomal DNA replication origin from position effects
61. n repeats and heat shock elements have distinct roles in chromatin structure and transcriptional activation of the Drosophila hsp26 gene
62. Activity of the c-myc replicator in an ectopic chromosomal location
63. Replicator dominance in a eukaryotic chromosome
64. RIP60 dimers and multiples of dimers assemble link structures at an origin of bidirectional replication in the dihydrofolate reductase amplicon of Chinese hamster ovary cells
65. Elements which stimulate gene amplification in mammalian cells: Role of recombinogenic sequences/structures and transcriptional activation
66. Identification and reconstitution of the origin recognition complex from Schizosaccharomyces pombe
67. DNA replication in yeast
68. Association of fission yeast Orp1 and Mcm6 proteins with chromosomal replication origins
69. Clustered adenine/thymine stretches are essential for function of a fission yeast replication origin
70. ORC-dependent and origin-specific initiation of DNA replication at defined loci in isolated yeast nuclei
71. High-resolution mapping of the origin of DNA replication in the hamster dihydrofolate reductase gene domain by competitive PCR
72. Attachment to the nuclear matrix mediates specific alterations in chromatin structure
73. Loss of transcriptional activity of a transgene is accompanied by DNA methylation and histone deacetylation and is prevented by insulators
74. Pausing in simian virus 40 DNA replication by a sequence containing (dG-dA)27.(dT-dC)27
75. The origin recognition complex interacts with a bipartite DNA binding site within yeast replicators
76. An origin of DNA replication and a transcription silencer require a common element
77. Transforming DNA integrates into the host chromosome
78. Initiation complex assembly at budding yeast replication origins begins with the recognition of a bipartite sequence by limiting amounts of the initiator, ORC
79. Nucleosome positioning can affect the function of a cis-acting DNA element in vivo
80. ORC binding, gene amplification, and the nature of metazoan replication origins
81. Requirement of stereospecific alignments for initiation from the simian virus 40 early promoter
82. Major DNA replication initiation sites in the c-myc locus in human cells
83. oriGNAI3: A narrow zone of preferential replication initiation in mammalian cells identified by 2D gel and competitive PCR replicon mapping techniques
84. Mutational analysis of the consensus sequence of a replication origin from yeast chromosome III
85. Mapping an origin of DNA replication at a single-copy locus in exponentially proliferating mammalian cells
86. Replication initiates in a broad zone in the amplified CHO dihydrofolate reductase domain
87. Mechanism of activation of simian virus 40 DNA replication by protein phosphatase
88. Activation of silent replication origins at autonomously replicating sequence elements near the HML locus in budding yeast
89. Lagging-strand, earlylabelling, and two-dimensional gel assays suggest multiple potential initiation sites in the Chinese hamster dihydrofolate reductase origin
90. Improved M13 phage cloning vectors and host strains: Nucleotide sequences of the M13mp18 and pUC19 vectors