Granzyme a produces bioactive IL-1β through a nonapoptotic inflammasome-independent pathway

Cell Reports

Volumn 9, Issue 3, 2014, Pages 910-917

  Hildebrand, Dagmar ^a   Bode, Konrad A ^a   Rieß, David ^a   Cerny, Daniela ^a   Waldhuber, Anna ^b   Römmler, Franziska ^b   Strack, Julia ^c   Korten, Simone ^d   Orth, Joachim H C ^c   Miethke, Thomas ^e   Heeg, Klaus ^a   Kubatzky, Katharina F ^a  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c UNIVERSITY OF FREIBURG   (Germany)

^d Labor Lademannbogen   (Germany)

^e MEDICAL FACULTY MANNHEIM HEIDELBERG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL TOXIN; GRANZYME A; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; PASTEURELLA MULTOCIDA TOXIN; STAT PROTEIN; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; GRANZYME; JANUS KINASE; PERFORIN; RHO KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; CYTOTOXICITY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IN VIVO STUDY; INFLAMMASOME INDEPENDENT PATHWAY; INFLAMMATION; MACROPHAGE; MOUSE; NONHUMAN; PASTEURELLA MULTOCIDA; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN PROCESSING; PROTEIN SYNTHESIS; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; ANIMAL; APOPTOSIS; BIOSYNTHESIS; DRUG EFFECTS; GENETIC TRANSCRIPTION; GENETICS; METABOLISM;

BACTERIA (MICROORGANISMS); PASTEURELLA MULTOCIDA;

ANIMALS; APOPTOSIS; BACTERIAL PROTEINS; BACTERIAL TOXINS; CASPASE 1; GRANZYMES; HUMANS; INFLAMMASOMES; INTERLEUKIN-1BETA; JANUS KINASES; MICE; NF-KAPPA B; PERFORIN; PROTEIN PROCESSING, POST-TRANSLATIONAL; RHO-ASSOCIATED KINASES; RHOA GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION; STAT TRANSCRIPTION FACTORS; TOLL-LIKE RECEPTORS; TRANSCRIPTION, GENETIC;

EID: 84919733859     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2014.10.003     Document Type: Article

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