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ChemMedChem

Volumn 10, Issue 1, 2015, Pages 94-106

Nucleoside mono- and diphosphate prodrugs of 2′,3′-dideoxyuridine and 2′,3′-dideoxy-2′,3′-didehydrouridine

(3) Pertenbreiter, Florian a Balzarini, Jan b Meier, Chris a

a UNIVERSITY OF HAMBURG (Germany)

b REGA INSTITUTE FOR MEDICAL RESEARCH (Belgium)

Author keywords

Antiviral agents; Bioreversible protection; Drug delivery; HIV; Nucleosides; Prodrugs

Indexed keywords

2',3' DIDEHYDRO 2',3' DIDEOXYURIDINE; 2',3' DIDEHYDRO 2',3' DIDEOXYURIDINE DERIVATIVE; 2',3' DIDEOXYURIDINE; 2',3' DIDEOXYURIDINE DERIVATIVE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; CELL EXTRACT; DRUG METABOLITE; NUCLEOSIDE ANALOG; NUCLEOSIDE DIPHOSPHATE KINASE; NUCLEOTIDE DERIVATIVE; PRODRUG; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG; 2',3' DIDEOXYNUCLEOSIDE DERIVATIVE; 2',3'-DIDEHYDRO-2',3'-DIDEOXYURIDINE; 2',3'-DIDEOXYURIDINE; NUCLEOSIDE; PYROPHOSPHORIC ACID DERIVATIVE;

ANTIVIRAL ACTIVITY; ARTICLE; CD4+ T LYMPHOCYTE; CHEMICAL MODIFICATION; CYTOPATHOGENIC EFFECT; DRUG EFFICACY; DRUG HYDROLYSIS; DRUG POTENCY; DRUG SYNTHESIS; DRUG TRANSFORMATION; ENZYME ASSAY; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME SUBSTRATE COMPLEX; HUMAN; HUMAN CELL; IN VITRO STUDY; PHOSPHORYLATION; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; CELL LINE; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECTS; HALF LIFE TIME; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; HYDROLYSIS; METABOLISM; SYNTHESIS;

ANTI-HIV AGENTS; CELL LINE; CELL PROLIFERATION; DIDEOXYNUCLEOSIDES; DIPHOSPHATES; HALF-LIFE; HIV-1; HIV-2; HUMANS; HYDROLYSIS; NUCLEOSIDE-DIPHOSPHATE KINASE; NUCLEOSIDES; PRODRUGS;

EID: 84919724816 PISSN: 18607179 EISSN: 18607187 Source Type: Journal
DOI: 10.1002/cmdc.201402295 Document Type: Article

Times cited : (28)

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