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ChemMedChem

Volumn 9, Issue 4, 2014, Pages 762-775

The DiPPro approach: Synthesis, hydrolysis, and antiviral activity of lipophilic d4T diphosphate prodrugs

(3) Schulz, Tilmann a Balzarini, Jan b Meier, Chris a

a UNIVERSITY OF HAMBURG (Germany)

b REGA INSTITUTE FOR MEDICAL RESEARCH (Belgium)

Author keywords

antivirals; bioreversible protection; nucleoside diphosphates; prodrugs; pronucleotides

Indexed keywords

ALKYL GROUP; BENZYL DERIVATIVE; ESTER DERIVATIVE; FATTY ACID; NUCLEOSIDE ANALOG; PHOSPHATE; PHOSPHORAMIDOUS ACID; PRODRUG; STAVUDINE; STAVUDINE DIPHOSPHATE; THYMIDINE KINASE; UNCLASSIFIED DRUG; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; PYROPHOSPHORIC ACID DERIVATIVE;

ANTIVIRAL ACTIVITY; ARTICLE; BIOTRANSFORMATION; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; DRUG DETERMINATION; DRUG HALF LIFE; DRUG HYDROLYSIS; DRUG POTENCY; DRUG STABILITY; DRUG SYNTHESIS; ENZYME MECHANISM; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; LIPOPHILICITY; NONHUMAN; OXIDATION; PH; PRIORITY JOURNAL; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; WILD TYPE; CD4+ T LYMPHOCYTE; CHEMICAL PHENOMENA; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; HUMAN; HYDROLYSIS; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; SYNTHESIS;

ANTI-HIV AGENTS; CD4-POSITIVE T-LYMPHOCYTES; DIPHOSPHATES; DOSE-RESPONSE RELATIONSHIP, DRUG; HIV-1; HIV-2; HUMANS; HYDROLYSIS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MICROBIAL SENSITIVITY TESTS; PRODRUGS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84897988289 PISSN: 18607179 EISSN: 18607187 Source Type: Journal
DOI: 10.1002/cmdc.201300500 Document Type: Article

Times cited : (41)

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