Chemoenzymatic syntheses and anti-HIV-1 activity of glucose-nucleoside conjugates as prodrugs

Bioconjugate Chemistry

Volumn 21, Issue 12, 2010, Pages 2239-2249

  Rodríguez Pérez, Tatiana ^a   Fernández, Susana ^a   Sanghvi, Yogesh S ^b   Detorio, Mervi ^c   Schinazi, Raymond F ^c   Gotor, Vicente ^a   Ferrero, Miguel ^a  

^a UNIVERSITY OF OVIEDO   (Spain)

^b RASAYAN INC   (United States)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (5' O DIMETHOXYTRITYL BETA DEXTRO RIBOFURANOSYL) 1,2,4 TRIAZOLE 3 CARBOXAMIDE; 1' (3 CARBAMOYL 1,2,4 TRIAZOYL) BETA DEXTRO RIBOFURANOSE 5' (ALPHA/BETA DEXTRO GLUCOPYRANOS 6 YL)PHOSPHATE; 1' ADENINYL BETA DEXTRO ARABINOFURANOSE 5' (ALPHA/BETA DEXTRO GLUCOPYRANOS 6 YL)PHOSPHATE; 1' CYTOSINYL BETA DEXTRO ARABINOFURANOSE 5'(ALPHA/BETA DEXTRO GLUCOPYRANOS 6 YL)PHOSPHATE; 2 CYANOETHYL (2',3' DIDEHYDRO 2',3' DIDEOXYTHYMIDIN 5' YL)1,2,3,4 TETRA O ACETYL ALPHA DEXTRO GLUCOPYRANOS 6 YL PHOSPHATE; 2 CYANOETHYL (2',3' DIDEHYDRO 2',3' DIDEOXYURIDIN 5' YL)1,2,3,4 TETRA O ACETYL ALPHA DEXTRO GLUCOPYRANOS 6 YL PHOSPHATE; 2 CYANOETHYL (2',3' DIDEOXYINOSIN 5' YL) 1,2,3,4 TETRA O ACETYL ALPHA DEXTRO GLUCOPYRANOS 6 YL PHOSPHATE; 2 CYANOETHYL (3' O LEVULINYL 5 IODO 2' DEOXYURIDIN 5' YL) 1,2,3,4 TETRA O ACETYL ALPHA DEXTRO GLUCOPYRANOS 6 YL PHOSPHATE; 2 CYANOETHYL (5' O LEVULINYL 5 IODO 2' DEOXYURIDIN 3' YL) 1,2,3,4 TETRA O ACETYL ALPHA DEXTRO GLUCOPYRANOS 6 YL PHOSPHATE; 2 CYANOETHYL N,N DIISOPROPYL (1,2,3,4 TETRA O ACETYL ALPHA DEXTRO GLUCOPYRANOSIDE 6 YL)PHYOSPHORAMIDITE; 2 CYANOETHYL [2',3' DI O ACETYL 1' (3 CARBAMOYL 1,2,4 TRIAZOYL)BETA DEXTRO RIBOFURANOS 5' YL] 1,2,3,4 TETRA O ACETYL ALPHA DEXTRO GLUCOPYRANOS 6 YL PHOSPHATE; 2 CYANOETHYL [2',3' DI O ACETYL 1' (N4 BENZOYLCYTOSINYL) BETA DEXTRO ARABINOFURANOS 5' YL] 1,2,3,4 TETRA O ACETYL ALPHA DEXTRO GLUCOPYRANOSYL 6 YL PHOSPHATE; 2 CYANOETHYL [2',3' DI O ACETYL 1' (N6 BENZOYLADENINYL) BETA DEXTRO ARABINOFURANOS 5' YL] 1,2,3,4 TETRA O ACETYL ALPHA DEXTRO GLUCOPYRANOSYL 6 YL PHOSPHATE; 2 CYANOETHYL [N6 (DIMETHYLAMINO)METHYLEN 2',3' DIDEOXYADENOSIN 5' YL] 1,2,3,4TETRA O ACETYL ALPHA DEXTRO GLUCOPYRANOS 6 YL PHOSPHATE; 2 DEOXY 5 IODOURIDINE 5' (ALPHA/BETA DEXTRO GLUCOPYRANOS 6 YL) PHOSPHATE; 2' DEOXY 5 IODOURIDINE 3' (ALPHA/BETA DEXTRO GLUCOPYRANOS 6 YL) PHOSPHATE; 2',3' DIDEHYDRO 2',3' DIDEOXYTHYMIDINE 5' (ALPHA/BETA DEXTRO GLUCOPYRANOS 6 YL)PHOSPHATE; 2',3' DIDEHYDRO 2',3' DIDEOXYURIDINE 5' (ALPHA/BETA DEXTRO GLUCOPYRANOS 6 YL)PHOSPHATE; 2',3' DIDEOXYADENOSINE 5' (ALPHA/BETA DEXTRO GLUCOPYRANOS 6 YL) PHOSPHATE; 2',3' DIDEOXYINOSINE 5' (ALPA/BETA DEXTRO GLUCOPYRANOS 6 YL) PHOSPHATE; GLUCOSYLCERAMIDASE; NUCLEOSIDE ANALOG; PHOSPHORAMIDOUS ACID; PHOSPHOTRIESTERASE; RIBAVIRIN; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CHEMOSENSITIVITY; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; LYMPHOCYTE; NONHUMAN; OUTCOME ASSESSMENT; PHYSICAL CHEMISTRY; POLYMERIZATION; SOLUBILITY; VERO CELL;

ARA; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 78650410911     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc1002168     Document Type: Article

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