Aryl nucleoside H-phosphonates. Part 16: Synthesis and anti-HIV-1 activity of di-aryl nucleoside phosphotriesters

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 9, 2009, Pages 3489-3498

  Romanowska, Joanna ^a   Szymańska Michalak, Agnieszka ^a   Boryski, Jerzy ^a   Stawiński, Jacek ^a   Kraszewski, Adam ^a   Loddo, Roberta ^b   Sanna, Giuseppina ^b   Collu, Gabriella ^b   Secci, Barbara ^b   Colla, Paolo La ^b  

^a INSTITUTE OF BIOORGANIC CHEMISTRY   (Poland)

^b UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

Anti HIV 1 activity; Nucleoside analogues; Phosphotriesters; Pro drugs; Pro nucleotides

Indexed keywords

2',3 ' DIDEOXYADENOSIN 5' YL PHENYL PHOSPHATE TRIETHYLAMMONIUM SALT; 2',3' DIDEOXYADENOSIN 5' YL PYRIDIN 3 YL PHOSPHATE TRIETHYLAMMONIUM SALT; 2',3' DIDEOXYURIDIN 5' YL PHENYL PHOSPHATE TRIETHYLAMMONIUM SALT; 2',3' DIDEOXYURIDIN 5' YL PYRIDIN 3 YL PHOSPHATE TRIETHYLAMMONIUM SALT; 2',3' DIDEOXYURIDIN 5' YL PYRIDIN 4 YL PHOSPHATE TRITRIETHYLAMMONIUM SALT; 3' AZIDO 3' DEOXYTHYMIDYN 5' YL 2 CHLOROPYRIDIN 3 YL PHOSPHATE TRIETHYLAMMONIUM SALT; 3' AZIDO 3' DEOXYTHYMIDYN 5' YL 2 METHYLPYRIDIN 3 YL PHOSPHATE TRIETHYLAMMONIUM SALT; 3' AZIDO 3' DEOXYTHYMIDYN 5' YL 2,4 DICHLOROPHENYL PHOSPHATE TRIETHYLAMMONIUM SALT; 3' AZIDO 3' DEOXYTHYMIDYN 5' YL 2,4 DICHLOROPHENYL PYRIDIN 3 YL PHOSPHATE; 3' AZIDO 3' DEOXYTHYMIDYN 5' YL 4 BROMOPHENYL PHOSPHATE TRIETHYLAMMONIUM SALT; 3' AZIDO 3' DEOXYTHYMIDYN 5' YL 4 BROMOPHENYL PYRIDIN 3 YL PHOSPHATE; 3' AZIDO 3' DEOXYTHYMIDYN 5' YL 4 CHLOROPHENYL PHOSPHATE TRIETHYLAMMONIUM SALT; 3' AZIDO 3' DEOXYTHYMIDYN 5' YL 4 CHLOROPHENYL PYRIDIN 3 YL PHOSPHATE; 3' AZIDO 3' DEOXYTHYMIDYN 5' YL 4 CYANOPHENYL PHOSPHATE TRIETHYLAMMONIUM SALT; 3' AZIDO 3' DEOXYTHYMIDYN 5' YL 4 CYANOPHENYL PYRIDIN 3 YL PHOSPHATE; 3' AZIDO 3' DEOXYTHYMIDYN 5' YL 5 CHLOROPYRIDIN 3 YL PHOSPHATE TRIETHYLAMMONIUM SALT; 3' AZIDO 3' DEOXYTHYMIDYN 5' YL 6 METHYLPYRIDIN 3 YL PHOSPHATE TRIETHYLAMMONIUM SALT; 3' AZIDO 3' DEOXYTHYMIDYN 5' YL BIS 2 METHYLPYRIDIN 3 YL PHOSPHATE; 3' AZIDO 3' DEOXYTHYMIDYN 5' YL BIS 6 METHYLPYRIDIN 3 YL PHOSPHATE; 3' AZIDO 3' DEOXYTHYMIDYN 5' YL BIS PYRIDIN 3 YL PHOSPHATE; 3' AZIDO 3' DEOXYTHYMIDYN 5' YL PHENYL PHOSPHATE TRIETHYLAMMONIUM SALT; 3' AZIDO 3' DEOXYTHYMIDYN 5' YL PHENYL PYRIDIN 3 YL PHOSPHATE; 3' AZIDO 3' DEOXYTHYMIDYN 5' YL PHENYL PYRIDIN 4 YL PHOSPHATE; 3' AZIDO 3' DEOXYTHYMIDYN 5' YL PYRIDIN 3 YL PHOSPHATE TRIETHYLAMMONIUM SALT; 3' AZIDO 3' DEOXYTHYMIDYN 5' YL PYRIDIN 3 YL PYRIDIN 4 YL PHOSPHATE; 3' AZIDO 3' DEOXYTHYMIDYN 5' YL PYRIDIN 4 YL PHOSPHATE TRIETHYLAMMONIUM SALT; DI ARYL NUCLEOSIDE PHOSPHOTRIESTER DERIVATIVE; ESTER DERIVATIVE; NUCLEOSIDE ANALOG; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CELL CULTURE; CULTURE MEDIUM; CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN;

ANTI-HIV AGENTS; CELL LINE; CELLS, CULTURED; HIV; HUMANS; HYDROXY ACIDS; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; NUCLEOSIDES; NUCLEOTIDES; PHOSPHONIC ACIDS; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 65249131256     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.02.033     Document Type: Article

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