Aryl H-phosphonates 17: (N-aryl)phosphoramidates of pyrimidine nucleoside analogues and their synthesis, selected properties, and anti-HIV activity

Journal of Medicinal Chemistry

Volumn 54, Issue 19, 2011, Pages 6482-6491

  Romanowska, Joanna ^a   Sobkowski, Michayjg ^a   Szymańska Michalak, Agnieszka ^a   Kołodziej, Krystian ^a   Da̧browska, Aleksandra ^b   Lipniacki, Andrzej ^b   Piasek, Andrzej ^b   Pietrusiewicz, Zofia M ^a   Figlerowicz, Marek ^a,c   Guranowski, Andrzej ^d   Boryski, Jerzy ^a   Stawiński, Jacek ^a   Kraszewski, Adam ^a  

^a INSTITUTE OF BIOORGANIC CHEMISTRY   (Poland)

^b National Institute of Medicines   (Poland)

^c POZNAN UNIVERSITY OF TECHNOLOGY   (Poland)

^d POZNA UNIVERSITY OF LIFE SCIENCES   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

2'.3' DIDEOXYURIDINE NUCLEOSIDES; 2,3' DIDEOXYURIDIN 5' YL [N (PYRIDIN 2 YL)]PHOSPHORAMIDATE; 2,3' DIDEOXYURIDIN 5' YL [N (PYRIDIN 3 YL)]PHOSPHORAMIDATE; 2,3' DIDEOXYURIDIN 5' YL [N (PYRIDIN 4 YL)]PHOSPHORAMIDATE; 3 AZIDO 3' DEOXYTHYMIDIN 5' YL [N (PYRIDIN 2 YL)]PHOSPHORAMIDATE; 3 AZIDO 3' DEOXYTHYMIDIN 5' YL [N (PYRIDIN 3 YL)]PHOSPHORAMIDATE; 3 AZIDO 3' DEOXYTHYMIDIN 5' YL [N (PYRIDIN 4 YL)]PHOSPHORAMIDATE; 3 AZIDO 3' DEOXYTHYMIDYN 5' YL (N 4 CHLOROPHENYL)PHOSPHORAMIDATE,TRIETHYLAMMONIUM SALT; 3 AZIDO 3' DEOXYTHYMIDYN 5' YL (N 4 METHYLPHENYL)PHOSPHORAMIDATE,TRIETHYLAMMONIUM SALT; 3 AZIDO 3' DEOXYTHYMIDYN 5' YL (NPHENYL)PHOSPHORAMIDATE TRIETHYLAMMONIUM SALT; AMINE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; AROMATIC COMPOUND; HETEROCYCLIC AMINE; IODINE; NUCLEOSIDE ANALOG; PHOSPHONIC ACID DERIVATIVE; PHOSPHORAMIDIC ACID DERIVATIVE; PYRIMIDINE NUCLEOSIDE DERIVATIVE; UNCLASSIFIED DRUG; WATER; ZIDOVUDINE 5' TRIPHOSPHATE;

ANTIVIRAL ACTIVITY; ARTICLE; CHEMICAL REACTION; CONDENSATION; CONTROLLED STUDY; DRUG SYNTHESIS; OXIDATION;

ANTI-HIV AGENTS; CELLS, CULTURED; HIV REVERSE TRANSCRIPTASE; HIV-1; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; PHOSPHONIC ACIDS; PYRIMIDINE NUCLEOSIDES; REVERSE TRANSCRIPTASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80053907413     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm2001103     Document Type: Article

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