Enzymatically activated cycloSal-d4T-monophosphates: The third generation of cycloSal-pronucleotides

Journal of Medicinal Chemistry

Volumn 50, Issue 7, 2007, Pages 1658-1667

  Gisch, Nicolas ^a   Balzarini, Jan ^b   Meier, Chris ^a  

^a UNIVERSITY OF HAMBURG   (Germany)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

5 DIACETOXYMETHYL 3 METHYLCYCLOSALICYL 2',3' DIDEOXY 2',3' DIDEHYDROTHYMIDINE MONOPHOSPHATE; 5 DIACETOXYMETHYL 3 TERT BUTYL CYCLOSALICYL 2',3' DIDEOXY 2',3' DIDEHYDROTHYMIDINE MONOPHOSPHATE; 5 DIACETOXYMETHYLCYCLOSALICYL 2',3' DIDEOXY 2',3' DIDEHYDROTHYMIDINE MONOPHOSPHATE; 5 FORMYL 3 TERT BUTYL METHYLCYCLOSALICYL 2',3' DIDEOXY 2',3' DIDEHYDROTHYMIDINE MONOPHOSPHATE; 5 FORMYLCYCLOSALICYL 2',3' DIDEOXY 2',3' DIDEHYDROTHYMIDINE MONOPHOSPHATE; 5 FORMYLMETHYLCYCLOSALICYL 2',3' DIDEOXY 2',3' DIDEHYDROTHYMIDINE MONOPHOSPHATE; ALDEHYDE; BUFFER; CELL EXTRACT; DICARBOXYLIC ACID; ESTERASE; NUCLEOTIDE DERIVATIVE; PHOSPHATE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CANCER CELL CULTURE; CARBON NUCLEAR MAGNETIC RESONANCE; CULTURE MEDIUM; DRUG ACTIVATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; HYDROLYSIS; NONHUMAN; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; SERUM; STRUCTURE ANALYSIS;

ANTI-HIV AGENTS; CELL LINE; HUMANS; HYDROLYSIS; PHOSPHORIC ACID ESTERS; STAVUDINE; STRUCTURE-ACTIVITY RELATIONSHIP; THYMIDINE;

EID: 34147154785     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0613267     Document Type: Article

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