Intracellular trapping of cyclosal-pronucleotides: Modification of prodrugs with amino acid esters

Journal of Medicinal Chemistry

Volumn 51, Issue 20, 2008, Pages 6592-6598

  Jessen, Henning J ^a   Balzarini, Jan ^b   Meier, Chris ^a  

^a UNIVERSITY OF HAMBURG   (Germany)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID DERIVATIVE; BUFFER; CARBOXYLIC ACID; CYCLOSAL PRONUCLEOTIDE DERIVATIVE; ESTER DERIVATIVE; NUCLEOSIDE DERIVATIVE; NUCLEOSIDE PHOSPHATE; NUCLEOTIDE DERIVATIVE; PHOSPHATE BUFFER; PRODRUG; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CELL MEMBRANE TRANSPORT; CHEMICAL MODIFICATION; CHEMICAL REACTION; DIFFUSION COEFFICIENT; DRUG ACCUMULATION; DRUG DELIVERY SYSTEM; DRUG HYDROLYSIS; DRUG MECHANISM; DRUG POTENCY; DRUG STABILITY; DRUG STRUCTURE; DRUG TRANSPORT; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; INTERNALIZATION; INTRACELLULAR TRAPPING; NONHUMAN; TECHNIQUE;

AMINO ACIDS; ANTIVIRAL AGENTS; CELL EXTRACTS; CELL LINE; CYCLIZATION; ESTERS; HIV-1; HUMANS; HYDROLYSIS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; NUCLEOTIDES; PRODRUGS; STAVUDINE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 54549092707     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm800815b     Document Type: Article

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