Ouabain elicits human glioblastoma cells apoptosis by generating reactive oxygen species in ERK-p66SHC-dependent pathway

Molecular and Cellular Biochemistry

Volumn 398, Issue 1-2, 2015, Pages 95-104

  Yan, Xiaofei ^a,b   Liang, FenLi ^a   Li, Dongmin ^a   Zheng, Jin ^b  

^a XI'AN JIAOTONG UNIVERSITY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF XI AN JIAOTONG UNIVERSITY   (China)

Author keywords

Glioblastoma; Na+ K+ ATPase; Ouabain; p66Shc; ROS

Indexed keywords

ADAPTOR PROTEIN; ADAPTOR PROTEIN P66SHC; CALCIUM; MITOGEN ACTIVATED PROTEIN KINASE; OUABAIN; RAS PROTEIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SCAVENGER; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; CASPASE 3; PROTEIN SHC; PROTEIN TYROSINE KINASE; SHC1 PROTEIN, HUMAN;

APOPTOSIS; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; GLIOBLASTOMA CELL LINE; GLIOMA CELL; HUMAN; HUMAN CELL; OXIDATION; PROTEIN PHOSPHORYLATION; CELL SURVIVAL; DOSE RESPONSE; DRUG EFFECTS; GENETICS; GLIOBLASTOMA; METABOLISM; PATHOLOGY; PHOSPHORYLATION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TIME; TUMOR CELL LINE; WESTERN BLOTTING;

STROPHANTHUS GRATUS;

APOPTOSIS; BLOTTING, WESTERN; CALCIUM; CASPASE 3; CELL LINE, TUMOR; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GLIOBLASTOMA; HUMANS; OUABAIN; PHOSPHORYLATION; RAS PROTEINS; REACTIVE OXYGEN SPECIES; RNA INTERFERENCE; SHC SIGNALING ADAPTOR PROTEINS; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES; TIME FACTORS;

EID: 84919717866     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-014-2208-y     Document Type: Article

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