Calcium oscillations triggered by cardiotonic steroids

FEBS Journal

Volumn 280, Issue 21, 2013, Pages 5450-5455

  Fontana, Jacopo M ^a   Burlaka, Ievgeniia ^a   Khodus, Georgiy ^a,b   Brismar, Hjalmar ^a,b   Aperia, Anita ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b ROYAL INSTITUTE OF TECHNOLOGY   (Sweden)

Author keywords

apoptosis; Ca2+ signaling; cardiotonic steroids; inositol trisphosphate receptor; intracellular Ca2+ oscillations; Na + K+ ATPase; NF B; organ development; ouabain; Src kinase

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); CALCIUM ION; DIGOXIN; INOSITOL 1,4,5 TRISPHOSPHATE RECEPTOR; LIGAND; MARINOBUFAGENIN; OUABAIN; PROTEIN BCL XL; PROTEIN TYROSINE KINASE; STEROID; TRANSCRIPTION FACTOR RELA; TYROSINE;

AMINO TERMINAL SEQUENCE; APOPTOSIS; CALCIUM SIGNALING; CONFERENCE PAPER; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HUMAN; MASS SPECTROMETRY; MITOCHONDRION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

APOPTOSIS; CA2+ SIGNALING; CARDIOTONIC STEROIDS; INOSITOL TRISPHOSPHATE RECEPTOR; INTRACELLULAR CA2+ OSCILLATIONS; NA+-K+-ATPASE; NF-ΚB; ORGAN DEVELOPMENT; OUABAIN; SRC KINASE;

ANIMALS; APOPTOSIS; CALCIUM SIGNALING; CARDIAC GLYCOSIDES; HUMANS; NF-KAPPA B; SIGNAL TRANSDUCTION; SODIUM-POTASSIUM-EXCHANGING ATPASE;

STROPHANTHUS GRATUS;

EID: 84886096465     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/febs.12448     Document Type: Conference Paper

References (70)

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30. Li J, Khodus GR, Kruusmägi M, Kamali-Zare P, Liu XL, Eklöf AC, Zelenin S, Brismar H, &, Aperia A, (2010) Ouabain protects against adverse developmental programming of the kidney. Nat Commun, doi: 10.1038/ncomms1043.
31. Tironi-Farinati C, Fabián Loidl C, Boccoli J, Parma Y, Fernandez-Miyakawa ME, &, Goldstein J, (2010) Intracerebroventricular Shiga toxin 2 increases the expression of its receptor globotriaosylceramide and causes dendritic abnormalities. J Neuroimmunol 222, 48-61.
32. Puschett JB, Agunanne E, &, Uddin MN, (2010) Emerging role of the bufadienolides in cardiovascular and kidney diseases. Am J Kidney Dis 56, 359-370.
33. Tian J, Haller S, Periyasamy S, Brewster P, Zhang H, Adlakha S, Fedorova OV, Xie ZJ, Bagrov AY, Shapiro JI, et al,. (2010) Renal ischemia regulates marinobufagenin release in humans. Hypertension 56, 914-919.
34. Vella A, Gerber TC, Hayes DL, &, Reeder GS, (1999) Digoxin, hypercalcaemia, and cardiac conduction. Postgrad Med J 75, 554-556.
35. Kennedy DJ, Vetteth S, Periyasamy SM, Kanj M, Fedorova L, Khouri S, Kahaleh MB, Xie Z, Malhotra D, Kolodkin NI, et al,. (2006) Central role for the cardiotonic steroid marinobufagenin in the pathogenesis of experimental uremic cardiomyopathy. Hypertension 47, 488-495.
36. Skou JC, (1957) The influence of some cations on an adenosine triphosphatase from peripheral nerves. Biochim Biophys Acta 23, 394-401.
37. Albers RW, (1967) Biochemical aspects of active transport. Annu Rev Biochem 36, 727-756.
38. Post RL, Hegyvary C, &, Kume S, (1972) Activation by adenosine triphosphate in the phosphorylation kinetics of sodium and potassium ion transport adenosine triphosphatase. J Biol Chem 247, 6530-654.
39. Geering K, (2008) Functional roles of Na, K-ATPase subunits. Curr Opin Nephrol Hypertens 17, 526-532.
40. Lingrel JB, (2010) The physiological significance of the cardiotonic steroid/ouabain-binding site of the Na, K-ATPase. Annu Rev Physiol 72, 395-412.
41. Schoner W, &, Scheiner-Bobis G, (2007) Endogenous and exogenous cardiac glycosides and their mechanisms of action. Am J Cardiovasc Drugs 7, 173-189.
42. Ogawa H, Shinoda T, Cornelius F, &, Toyoshima C, (2009) Crystal structure of the sodium-potassium pump (Na+, K+-ATPase) with bound potassium and ouabain. Proc Natl Acad Sci USA 106, 13742-13747.
43. Cornelius F, Mahmmoud YA, &, Toyoshima C, (2011) Metal fluoride complexes of Na, K-ATPase: characterization of fluoride-stabilized phosphoenzyme analogues and their interaction with cardiotonic steroids. J Biol Chem 26, 29882-29892.
44. Cornelius F, Kanai R, &, Toyoshima C, (2013) A structural view on the functional importance of the sugar moiety and steroid hydroxyls of cardiotonic steroids in binding to Na, K-ATPase. J Biol Chem 288, 6602-6616.
45. Bagrov AY, Shapiro JI, &, Fedorova OV, (2009) Endogenous cardiotonic steroids: physiology, pharmacology, and novel therapeutic targets. Pharmacol Rev 61, 9-38.
46. Aperia A, (2007) New roles for an old enzyme: Na, K-ATPase emerges as an interesting drug target. J Intern Med 261, 44-52.
47. Aperia A, (2010) 2011 Homer Smith Award: to serve and protect: classic and novel roles for Na+, K+ -adenosine triphosphatase. J Am Soc Nephrol 23, 1283-1290.
48. Pierre SV, &, Xie Z, (2006) The Na, K-ATPase receptor complex: its organization and membership. Cell Biochem Biophys 46, 303-316.
49. Li Z, &, Xie Z, (2009) The Na/K-ATPase/Src complex and cardiotonic steroid-activated protein kinase cascades. Pflugers Arch 457, 635-644.
50. Aizman O, Uhlén P, Lal M, Brismar H, &, Aperia A, (2001) Ouabain, a steroid hormone that signals with slow calcium oscillations. Proc Natl Acad Sci USA 98, 13420-13424.
51. Miyakawa-Naito A, Uhlén P, Lal M, Aizman O, Mikoshiba K, Brismar H, Zelenin S, &, Aperia A, (2003) Cell signaling microdomain with Na, K-ATPase and inositol 1,4,5-trisphosphate receptor generates calcium oscillations. J Biol Chem 278, 50355-50361.
52. Zhang S, Malmersjö S, Li J, Ando H, Aizman O, Uhlén P, Mikoshiba K, &, Aperia A, (2006) Distinct role of the N-terminal tail of the Na, K-ATPase catalytic subunit as a signal transducer. J Biol Chem 281, 21954-21962.
53. Liu X, Spicarová Z, Rydholm S, Li J, Brismar H, &, Aperia A, (2008) Ankyrin B modulates the function of Na, K-ATPase/inositol 1,4,5-trisphosphate receptor signaling microdomain. J Biol Chem 283, 11461-11468.
54. +-ATPase to growth-related genes in cardiac myocytes. The roles of Ras and mitogen-activated protein kinases. J Biol Chem 273, 15249-15256.
55. +-ATPase. J Biol Chem 275, 27832-27837.
56. Kotova O, Al-Khalili L, Talia S, Hooke C, Fedorova OV, Bagrov AY, &, Chibalin AV, (2006) Cardiotonic steroids stimulate glycogen synthesis in human skeletal muscle cells via a Src- and ERK1/2-dependent mechanism. J Biol Chem 281, 20085-20094.
57. +-ATPase forms a functional signaling complex. Mol Biol Cell 17, 317-326.
58. Aydemir-Koksoy A, Abramowitz J, &, Allen JC, (2001) Ouabain-induced signaling and vascular smooth muscle cell proliferation. J Biol Chem 276, 46605-46611.
59. +-ATPase and the epidermal growth factor receptor relays the signal from ouabain to mitogen-activated protein kinases. J Biol Chem 277, 18694-18702.
60. Berridge MJ, Lipp P, &, Bootman MD, (2000) The versatility and universality of calcium signalling. Nat Rev Mol Cell Biol 1, 11-21.
61. 2+ oscillations. Science 279, 227-230.
62. Hu Q, Deshpande S, Irani K, &, Ziegelstein RC, (1999) [Ca(2+)](i) oscillation frequency regulates agonist-stimulated NF-kappaB transcriptional activity. J Biol Chem 274, 33995-33998.
63. Li J, Zelenin S, Aperia A, &, Aizman O, (2006) Low doses of ouabain protect from serum deprivation-triggered apoptosis and stimulate kidney cell proliferation via activation of NF-kappaB. J Am Soc Nephrol 17, 1848-1857.
64. Burlaka I, Liu XL, Rebetz J, Arvidsson I, Yang L, Brismar H, Karpman D, &, Aperia A, (2013) Ouabain protects against Shiga toxin-triggered apoptosis by reversing the imbalance between Bax and Bcl-xL. J Am Soc Nephrol. Epub ahead of print.
65. Li J, Khodus GR, Kruusmägi M, Kamali-Zare P, Liu XL, Eklöf AC, Zelenin S, Brismar H, &, Aperia A, (2010) Ouabain protects against adverse developmental programming of the kidney. Nat Commun, doi: 10.1038/ncomms1043.
66. Tironi-Farinati C, Fabián Loidl C, Boccoli J, Parma Y, Fernandez-Miyakawa ME, &, Goldstein J, (2010) Intracerebroventricular Shiga toxin 2 increases the expression of its receptor globotriaosylceramide and causes dendritic abnormalities. J Neuroimmunol 222, 48-61.
67. Puschett JB, Agunanne E, &, Uddin MN, (2010) Emerging role of the bufadienolides in cardiovascular and kidney diseases. Am J Kidney Dis 56, 359-370.
68. Tian J, Haller S, Periyasamy S, Brewster P, Zhang H, Adlakha S, Fedorova OV, Xie ZJ, Bagrov AY, Shapiro JI, et al,. (2010) Renal ischemia regulates marinobufagenin release in humans. Hypertension 56, 914-919.
69. Vella A, Gerber TC, Hayes DL, &, Reeder GS, (1999) Digoxin, hypercalcaemia, and cardiac conduction. Postgrad Med J 75, 554-556.
70. Kennedy DJ, Vetteth S, Periyasamy SM, Kanj M, Fedorova L, Khouri S, Kahaleh MB, Xie Z, Malhotra D, Kolodkin NI, et al,. (2006) Central role for the cardiotonic steroid marinobufagenin in the pathogenesis of experimental uremic cardiomyopathy. Hypertension 47, 488-495.