Thrombin-induced NF-κB activation and IL-8/CXCL8 release is mediated by c-Src-dependent Shc, Raf-1, and ERK pathways in lung epithelial cells

Cellular Signalling

Volumn 25, Issue 5, 2013, Pages 1166-1175

  Lin, Chien Huang ^a   Yu, Ming Chih ^a,b   Chiang, Chia Chieh ^a   Bien, Mauo Ying ^a,c   Chien, Ming Hsien ^a,b   Chen, Bing Chang ^a  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Epithelial cells; IL 8 CXCL8; Lung; NF B; Shc; Thrombin

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 3 (3,5 DIBROMO 4 HYDROXYBENZYLIDENE) 1,3 DIHYDRO 5 IODO 2 INDOLONE; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN BETA GAMMA SUBUNIT; I KAPPA B KINASE ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; LUCIFERASE; MITOGEN ACTIVATED PROTEIN KINASE; MUTANT PROTEIN; PROTEIN KINASE P60; PROTEIN P46; PROTEIN P52; PROTEIN SHC; RAF PROTEIN; SMALL INTERFERING RNA; THROMBIN; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME ACTIVATION; ENZYME ACTIVITY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LUNG ALVEOLUS EPITHELIUM; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

CELL LINE, TUMOR; EPITHELIAL CELLS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLAVONOIDS; HUMANS; I-KAPPA B KINASE; INDOLES; INTERLEUKIN-8; LUNG; NF-KAPPA B; PHENOLS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-RAF; RNA INTERFERENCE; RNA, SMALL INTERFERING; SHC SIGNALING ADAPTOR PROTEINS; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES; THROMBIN;

EID: 84875001127     PISSN: 08986568     EISSN: 18733913     Source Type: Journal    
DOI: 10.1016/j.cellsig.2013.01.018     Document Type: Article

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