OCT1 is a determinant of synbindin-related ERK signalling with independent prognostic significance in gastric cancer

Gut

Volumn 64, Issue 1, 2015, Pages 37-48

  Qian, Jin ^a   Kong, Xuan ^a   Deng, Niantao ^b   Tan, Patrick ^b,c   Chen, Haoyan ^a   Wang, Jilin ^a   Li, Zhaoli ^d   Hu, Ye ^a   Zou, Weiping ^e   Xu, Jie ^a   Fang, Jing Yuan ^a  

^a School of Medicine   (China)

^b DUKE NUS MEDICAL SCHOOL   (Singapore)

^c GENOME INSTITUTE OF SINGAPORE   (Singapore)

^d INSTITUTE OF PLANT PROTECTION   (China)

^e UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; OCTAMER TRANSCRIPTION FACTOR 1; REGULATOR PROTEIN; SYNBINDIN; UNCLASSIFIED DRUG; NERVE PROTEIN; ORGANIC CATION TRANSPORTER 1; SYNBINDIN PROTEIN, HUMAN; VESICULAR TRANSPORT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER PROGNOSIS; CANCER SURVIVAL; CELL INVASION; CELL PROLIFERATION; CONTROLLED STUDY; COPY NUMBER VARIATION; FLUORESCENCE IN SITU HYBRIDIZATION; GENE AMPLIFICATION; GENE OVEREXPRESSION; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MAJOR CLINICAL STUDY; MOUSE; NONHUMAN; OCT1 GENE; PREDICTIVE VALUE; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; STOMACH CANCER; TUMOR GROWTH; UPREGULATION; ANIMAL; PATHOPHYSIOLOGY; PHYSIOLOGY; PROGNOSIS; STOMACH TUMOR;

ANIMALS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; MAP KINASE SIGNALING SYSTEM; MICE; NERVE TISSUE PROTEINS; ORGANIC CATION TRANSPORTER 1; PROGNOSIS; STOMACH NEOPLASMS; VESICULAR TRANSPORT PROTEINS;

EID: 84919710075     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gutjnl-2013-306584     Document Type: Article

References (44)

1. Coupland VH, Lagergren J, Luchtenborg M, et al. Hospital volume, proportion resected and mortality from oesophageal and gastric cancer: a population-based study in England, 2004-2008. Gut 2013; 62: 961-6.
2. Camargo MC, Kim WH, Chiaravalli AM, et al. Improved survival of gastric cancer with tumour Epstein-Barr virus positivity: an international pooled analysis. Gut 2014; 63: 236-43.
3. Shibata W, Ariyama H, Westphalen CB, et al. Stromal cell-derived factor-1 overexpression induces gastric dysplasia through expansion of stromal myofibroblasts and epithelial progenitors. Gut 2013; 62: 192-200.
4. Wang S, Wu X, Zhang J, et al. CHIP functions as a novel suppressor of tumour angiogenesis with prognostic significance in human gastric cancer. Gut 2013; 62: 496-508.
5. Paterson AL, Shannon NB, Lao-Sirieix P, et al. A systematic approach to therapeutic target selection in oesophago-gastric cancer. Gut 2013; 62: 1415-24.
6. Deng N, Goh LK, Wang H, et al. A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic targets. Gut 2012; 61: 673-84.
7. Dulak AM, Schumacher SE, van Lieshout J, et al. Gastrointestinal adenocarcinomas of the esophagus, stomach, and colon exhibit distinct patterns of genome instability and oncogenesis. Cancer Res 2012; 72: 4383-93.
8. Kholodenko BN, Hancock JF, Kolch W. Signalling ballet in space and time. Nat Rev Mol Cell Biol 2010; 11: 414-26.
9. Kong X, Qian J, Chen LS, et al. Synbindin in extracellular signal-regulated protein kinase spatial regulation and gastric cancer aggressiveness. J Natl Cancer Inst 2013; 105: 1738-49.
10. Lee MC, Toh LL, Yaw LP, et al. Drosophila octamer elements and Pdm-1 dictate the coordinated transcription of core histone genes. J Biol Chem 2010; 285: 9041-53.
11. Wang VE, Tantin D, Chen J, et al. B cell development and immunoglobulin transcription in Oct-1-deficient mice. Proc Natl Acad Sci U S A 2004; 101: 2005-10.
12. Bertolino E, Reddy K, Medina KL, et al. Regulation of interleukin 7-dependent immunoglobulin heavy-chain variable gene rearrangements by transcription factor STAT5. Nat Immunol 2005; 6: 836-43.
13. Shakya A, Cooksey R, Cox JE, et al. Oct1 loss of function induces a coordinate metabolic shift that opposes tumorigenicity. Nat Cell Biol 2009; 11: 320-7.
14. Jin T, Li H. Pou homeodomain protein OCT1 is implicated in the expression of the caudal-related homeobox gene Cdx-2. J Biol Chem 2001; 276: 14752-8.
15. Almeida R, Almeida J, Shoshkes M, et al. OCT-1 is over-expressed in intestinal metaplasia and intestinal gastric carcinomas and binds to, but does not transactivate, CDX2 in gastric cells. J Pathol 2005; 207: 396-401.
16. Hwang-Verslues WW, Chang PH, Jeng YM, et al. Loss of corepressor PER2 under hypoxia up-regulates OCT1-mediated EMT gene expression and enhances tumor malignancy. Proc Natl Acad Sci U S A 2013; 110: 12331-6.
17. Ethell IM, Hagihara K, Miura Y, et al. Synbindin, a novel syndecan-2-binding protein in neuronal dendritic spines. J Cell Biol 2000; 151: 53-68.
18. Summersgill B, Clark J, Shipley J. Fluorescence and chromogenic in situ hybridization to detect genetic aberrations in formalin-fixed paraffin embedded material, including tissue microarrays. Nat Protoc 2008; 3: 220-34.
19. Goldman M, Craft B, Swatloski T, et al. The UCSC cancer genomics browser: update 2013. Nucleic Acids Res 2013; 41:D949-54.
20. Buffart TE, Carvalho B, van Grieken NC, et al. Losses of chromosome 5q and 14q are associated with favorable clinical outcome of patients with gastric cancer. Oncologist 2012; 17: 653-62.
21. Ooi CH, Ivanova T, Wu J, et al. Oncogenic pathway combinations predict clinical prognosis in gastric cancer. PLoS Genet 2009; 5:e1000676.
22. Brunner AL, Beck AH, Edris B, et al. Transcriptional profiling of long non-coding RNAs and novel transcribed regions across a diverse panel of archived human cancers. Genome Biol 2012; 13:R75.
23. Subramanian A, Kuehn H, Gould J, et al. GSEA-P: a desktop application for Gene Set Enrichment Analysis. Bioinformatics 2007; 23: 3251-3.
24. Odrowaz Z, Sharrocks AD. ELK1 uses different DNA binding modes to regulate functionally distinct classes of target genes. PLoS Genet 2012; 8:e1002694.
25. Gabdoulline R, Eckweiler D, Kel A, et al. 3DTF: a web server for predicting transcription factor PWMs using 3D structure-based energy calculations. Nucleic Acids Res 2012; 40:W180-5.
26. Ferraris L, Stewart AP, Kang J, et al. Combinatorial binding of transcription factors in the pluripotency control regions of the genome. Genome Res 2011; 21: 1055-64.
27. Cui J, Chen Y, Chou WC, et al. An integrated transcriptomic and computational analysis for biomarker identification in gastric cancer. Nucleic Acids Res 2011; 39: 1197-207.
28. Dimitri CA, Dowdle W, MacKeigan JP, et al. Spatially separate docking sites on ERK2 regulate distinct signaling events in vivo. Curr Biol 2005; 15: 1319-24.
29. Ritchie DW, Venkatraman V. Ultra-fast FFT protein docking on graphics processors. Bioinformatics 2010; 26: 2398-405.
30. Mace PD, Wallez Y, Egger MF, et al. Structure of ERK2 bound to PEA-15 reveals a mechanism for rapid release of activated MAPK. Nat Commun 2013; 4: 1681.
31. Kummer L, Parizek P, Rube P, et al. Structural and functional analysis of phosphorylation-specific binders of the kinase ERK from designed ankyrin repeat protein libraries. Proc Natl Acad Sci USA 2012; 109:E2248-57.
32. Hornbeck PV, Chabra I, Kornhauser JM, et al. PhosphoSite: a bioinformatics resource dedicated to physiological protein phosphorylation. Proteomics 2004; 4: 1551-61.
33. Wang Z, Zhu S, Shen M, et al. STAT3 is involved in esophageal carcinogenesis through regulation of Oct-1. Carcinogenesis 2013; 34: 678-88.
34. Reiterer V, Fey D, Kolch W, et al. Pseudophosphatase STYX modulates cell-fate decisions and cell migration by spatiotemporal regulation of ERK1/2. Proc Natl Acad Sci U S A 2013; 110:E2934-43.
35. Kang J, Shakya A, Tantin D. Stem cells, stress, metabolism and cancer: a drama in two Octs. Trends Biochem Sci 2009; 34: 491-9.
36. Maddox J, Shakya A, South S, et al. Transcription factor Oct1 is a somatic and cancer stem cell determinant. PLoS Genet 2012; 8:e1003048.
37. Khurana SS, Riehl TE, Moore BD, et al. The hyaluronic acid receptor CD44 coordinates normal and metaplastic gastric epithelial progenitor cell proliferation. J Biol Chem 2013; 288: 16085-97.
38. Wang YK, Zhu YL, Qiu FM, et al. Activation of Akt and MAPK pathways enhances the tumorigenicity of CD133+ primary colon cancer cells. Carcinogenesis 2010; 31: 1376-80.
39. Rybak AP, Ingram AJ, Tang D. Propagation of human prostate cancer stem-like cells occurs through EGFR-mediated ERK activation. PloS ONE 2013; 8:e61716.
40. Ahn HJ, Kim G, Park KS. Ell3 stimulates proliferation, drug resistance, and cancer stem cell properties of breast cancer cells via a MEK/ERK-dependent signaling pathway. Biochem Biophys Res Commun 2013; 437: 557-64.
41. Nakada M, Nambu E, Furuyama N, et al. Integrin alpha3 is overexpressed in glioma stem-like cells and promotes invasion. Br J Cancer 2013; 108: 2516-24.
42. Zhang W, Mendoza MC, Pei X, et al. Down-regulation of CMTM8 induces epithelial-to-mesenchymal transition-like changes via c-MET/extracellular signal-regulated kinase (ERK) signaling. J Biol Chem 2012; 287: 11850-8.
43. Ha GH, Park JS, Breuer EK. TACC3 promotes epithelial-mesenchymal transition (EMT) through the activation of PI3 K/Akt and ERK signaling pathways. Cancer Lett 2013; 332: 63-73.
44. Elsum IA, Martin C, Humbert PO. Scribble regulates an EMT polarity pathway through modulation of MAPK-ERK signaling to mediate junction formation. J Cell Sci 2013; 126: 3990-9.