A gp41 MPER-specific Llama VHH Requires a Hydrophobic CDR3 for Neutralization but not for Antigen Recognition

PLoS Pathogens

Volumn 9, Issue 3, 2013, Pages

  Lutje Hulsik, David ^a   Liu, Ying ying ^b,m   Strokappe, Nika M ^b   Battella, Simone ^b   El Khattabi, Mohamed ^b   McCoy, Laura E ^c   Sabin, Charles ^a   Hinz, Andreas ^a,n   Hock, Miriam ^a   Macheboeuf, Pauline ^a   Bonvin, Alexandre M J J ^d   Langedijk, Johannes P M ^e,o   Davis, David ^f   Forsman Quigley, Anna ^c   Aasa Chapman, Marlén M I ^c   Seaman, Michael S ^g   Ramos, Alejandra ^h   Poignard, Pascal ^h,i   Favier, Adrien ^j,k   Simorre, Jean Pierre ^j,k   Weiss, Robin A ^c   Verrips, C Theo ^b,l   Weissenhorn, Winfried ^a   Rutten, Lucy ^b   more..

^a UNIV GRENOBLE ALPES   (France)

^b UTRECHT UNIVERSITY   (Netherlands)

^c MEDICAL RESEARCH COUNCIL   (United Kingdom)

^d UTRECHT UNIVERSITY   (Netherlands)

^e Pepscan Systems   (Netherlands)

^f BIOMEDICAL PRIMATE RESEARCH CENTRE   (Netherlands)

^g HARVARD MEDICAL SCHOOL   (United States)

^h SCRIPPS RESEARCH INSTITUTE   (United States)

ⁱ INTERNATIONAL AIDS VACCINE INITIATIVE   (United States)

^j INSTITUT DE BIOLOGIE STRUCTURALE   (France)

^k CEA GRENOBLE   (France)

^l QVQ BV   (Netherlands)

^m TIANJIN MEDICAL UNIVERSITY   (China)

ⁿ GOETHE UNIVERSITY   (Germany)

^o CRUCELL HOLLAND BV   (Netherlands)

more..

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN GP 41; MEMBRANE PROXIMAL EXTERNAL REGION BINDING ANTIBODY; MEMBRANE PROXIMAL EXTERNAL REGION BINDING ANTIBODY VHH 2H10; NEUTRALIZING ANTIBODY; PROTEOLIPOSOME; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIBODY PRODUCTION; ANTIGEN ANTIBODY REACTION; ANTIGEN PURIFICATION; ANTIGEN RECOGNITION; ARTICLE; CRYSTALLIZATION; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITOPE MAPPING; IMMUNIZATION; ISOTHERMAL TITRATION CALORIMETRY; MOLECULAR MODEL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PROTEIN EXPRESSION; PROTEIN LIPID INTERACTION; PROTEIN PURIFICATION; PROTEIN SECONDARY STRUCTURE; REGULATORY DNA SEQUENCE; SITE DIRECTED MUTAGENESIS; STRUCTURE ANALYSIS; SURFACE PLASMON RESONANCE; X RAY;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, NEUTRALIZING; BASE SEQUENCE; CAMELIDS, NEW WORLD; CELL LINE; COMPLEMENTARITY DETERMINING REGIONS; EPITOPES; HIV ANTIBODIES; HIV ENVELOPE PROTEIN GP41; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; IMMUNIZATION; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NEUTRALIZATION TESTS; PROTEOLIPIDS; SINGLE-DOMAIN ANTIBODIES; SURFACE PLASMON RESONANCE;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS 1; LAMA (MAMMAL); LAMA GLAMA; SIMIAN-HUMAN IMMUNODEFICIENCY VIRUS;

EID: 84875972349     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1003202     Document Type: Article

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