Defective B-cell memory in patients with Down syndrome

Journal of Allergy and Clinical Immunology

Volumn 134, Issue 6, 2014, Pages 1346-1353.e9

  Verstegen, Ruud H J ^a   Driessen, Gertjan J ^b   Bartol, Sophinus J W ^b   Van Noesel, Carel J M ^c   Boon, Louis ^d   Van Der Burg, Mirjam ^b   Van Dongen, Jacques J M ^b   De Vries, Esther ^a   Van Zelm, Menno C ^b  

^a JEROEN BOSCH HOSPITAL   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c ACADEMIC MEDICAL CENTER   (Netherlands)

^d BIOCEROS   (Netherlands)

Author keywords

antibody; B cell; common variable immunodeficiency; Down syndrome; IgA; IgM; plasma cell; selection; somatic hypermutation

Indexed keywords

B CELL ACTIVATING FACTOR; CD27 ANTIGEN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN D; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M;

ADOLESCENT; ANTIBODY RESPONSE; ARTICLE; B LYMPHOCYTE; B LYMPHOCYTE ACTIVATION; BIOCHEMICAL COMPOSITION; CELL DIVISION; CELL PROLIFERATION; CHILD; CLINICAL ARTICLE; COMMON VARIABLE IMMUNODEFICIENCY; CONTROLLED STUDY; DOWN SYNDROME; EFFECTOR CELL; FEMALE; GENE REARRANGEMENT; GERMINAL CENTER; HUMAN; HUMAN CELL; HUMORAL IMMUNE DEFICIENCY; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOLOGICAL MEMORY; LYMPHOCYTE COUNT; LYMPHOCYTE PROLIFERATION; LYMPHOCYTE SUBPOPULATION; MALE; MEMORY CELL; MUCOSAL IMMUNITY; PHENOTYPE; PLASMA CELL; SOMATIC HYPERMUTATION; TONSIL; CELL DIFFERENTIATION; CYTOLOGY; IMMUNOLOGY; PALATINE TONSIL; PRESCHOOL CHILD;

ADOLESCENT; B-LYMPHOCYTE SUBSETS; B-LYMPHOCYTES; CELL DIFFERENTIATION; CHILD; CHILD, PRESCHOOL; COMMON VARIABLE IMMUNODEFICIENCY; DOWN SYNDROME; FEMALE; GERMINAL CENTER; HUMANS; IMMUNOGLOBULIN A; IMMUNOGLOBULIN CLASS SWITCHING; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; IMMUNOLOGIC MEMORY; LYMPHOCYTE COUNT; MALE; PALATINE TONSIL; PLASMA CELLS;

EID: 84919662396     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2014.07.015     Document Type: Article

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