Soluble BAFF levels inversely correlate with peripheral B cell numbers and the expression of BAFF receptors

Journal of Immunology

Volumn 188, Issue 1, 2012, Pages 497-503

  Kreuzaler, Matthias ^a   Rauch, Melanie ^a   Salzer, Ulrich ^b   Birmelin, Jennifer ^c   Rizzi, Marta ^b   Grimbacher, Bodo ^c   Plebani, Alessandro ^d   Lougaris, Vassilios ^d   Quinti, Isabella ^e   Thon, Vojtech ^f   Litzman, Jiri ^f   Schlesier, Michael ^b   Warnatz, Klaus ^b   Thiel, Jens ^b   Rolink, Antonius G ^a   Eibel, Hermann ^b  

^a UNIVERSITY OF BASEL   (Switzerland)

^b UNIVERSITY OF FREIBURG   (Germany)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d UNIVERSITY OF BRESCIA   (Italy)

^e SAPIENZA UNIVERSITY OF ROME   (Italy)

^f ST ANNE S UNIVERSITY HOSPITAL   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

B CELL ACTIVATING FACTOR; B CELL ACTIVATING FACTOR RECEPTOR; C REACTIVE PROTEIN; CD20 ANTIGEN; MONOCLONAL ANTIBODY; RAG2 PROTEIN; TRANSMEMBRANE ACTIVATOR AND CAML INTERACTOR;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADOLESCENT; ADULT; AGE; AGED; ANIMAL EXPERIMENT; ARTICLE; ASPLENIA; B LYMPHOCYTE; CD40L DEFICIENCY; CHILD; CHRONIC LYMPHATIC LEUKEMIA; COMMON VARIABLE IMMUNODEFICIENCY; CONTROLLED STUDY; FEMALE; GENE MUTATION; GOOD SYNDROME; HUMAN; HUMAN CELL; HUMORAL IMMUNE DEFICIENCY; IMMUNOGLOBULIN A DEFICIENCY; IMMUNOGLOBULIN G DEFICIENCY; IMMUNOGLOBULIN M DEFICIENCY; LYMPHOCYTE COUNT; LYMPHOCYTE DEPLETION; LYMPHOCYTOSIS; MOUSE; MYOTONIC DYSTROPHY; NEUTROPHIL COUNT; NONHUMAN; PERIPHERAL LYMPHOCYTE; POLYCLONAL B LYMPHOCYTOSIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT; SPLENECTOMY;

ADOLESCENT; ADULT; AGED; ANIMALS; ANTIBODIES, MONOCLONAL, MURINE-DERIVED; B-CELL ACTIVATING FACTOR; B-CELL ACTIVATION FACTOR RECEPTOR; B-LYMPHOCYTES; CHILD; CHILD, PRESCHOOL; HUMANS; IMMUNOLOGIC DEFICIENCY SYNDROMES; INFANT; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; LYMPHOCYTE COUNT; MICE; MICE, INBRED BALB C; MICE, TRANSGENIC; MIDDLE AGED; RATS; RATS, INBRED LEW;

EID: 84855366637     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1102321     Document Type: Article

References (49)

1. Mackay, F., and P. Schneider. 2009. Cracking the BAFF code. Nat. Rev. Immunol. 9: 491-502.
2. Claudio, E., K. Brown, S. Park, H. Wang, and U. Siebenlist. 2002. BAFF-induced NEMO-independent processing of NF-kB2 in maturing B cells. Nat. Immunol. 3: 958-965. (Pubitemid 35154010)
3. Enzler, T., G. Bonizzi, G. J. Silverman, D. C. Otero, G. F. Widhopf, A. Anzelon- Mills, R. C. Rickert, and M. Karin. 2006. Alternative and classical NF-κB signaling retain autoreactive B cells in the splenic marginal zone and result in lupus-like disease. Immunity 25: 403-415. (Pubitemid 44354213)
4. Sasaki, Y., E. Derudder, E. Hobeika, R. Pelanda, M. Reth, K. Rajewsky, and M. Schmidt-Supprian. 2006. Canonical NF-κB activity, dispensable for B cell development, replaces BAFF-receptor signals and promotes B cell proliferation upon activation. Immunity 24: 729-739. (Pubitemid 43867365)
5. Warnatz, K., U. Salzer, M. Rizzi, B. Fischer, S. Gutenberger, J. Böhm, A. K. Kienzler, Q. Pan-Hammarström, L. Hammarström, M. Rakhmanov, et al. 2009. B-cell activating factor receptor deficiency is associated with an adultonset antibody deficiency syndrome in humans. Proc. Natl. Acad. Sci. USA 106: 13945-13950.
6. Schiemann, B., J. L. Gommerman, K. Vora, T. G. Cachero, S. Shulga-Morskaya, M. Dobles, E. Frew, and M. L. Scott. 2001. An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway. Science 293: 2111-2114. (Pubitemid 32848063)
7. Mackay, F., S. A. Woodcock, P. Lawton, C. Ambrose, M. Baetscher, P. Schneider, J. Tschopp, and J. L. Browning. 1999. Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations. J. Exp. Med. 190: 1697-1710. (Pubitemid 30002351)
8. Cheema, G. S., V. Roschke, D. M. Hilbert, and W. Stohl. 2001. Elevated serum B lymphocyte stimulator levels in patients with systemic immune-based rheumatic diseases. Arthritis Rheum. 44: 1313-1319. (Pubitemid 32537529)
9. Zhang, J., V. Roschke, K. P. Baker, Z. Wang, G. S. Alarcón, B. J. Fessler, H. Bastian, R. P. Kimberly, and T. Zhou. 2001. Cutting edge: a role for B lymphocyte stimulator in systemic lupus erythematosus. J. Immunol. 166: 6-10. (Pubitemid 32038409)
10. Groom, J., S. L. Kalled, A. H. Cutler, C. Olson, S. A. Woodcock, P. Schneider, J. Tschopp, T. G. Cachero, M. Batten, J. Wheway, et al. 2002. Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjögren's syndrome. J. Clin. Invest. 109: 59-68. (Pubitemid 34052542)
11. Jacobi, A. M., W. Huang, T. Wang, W. Freimuth, I. Sanz, R. Furie, M. Mackay, C. Aranow, B. Diamond, and A. Davidson. 2010. Effect of long-term belimumab treatment on B cells in systemic lupus erythematosus: extension of a phase II, double-blind, placebo-controlled, dose-ranging study. Arthritis Rheum. 62: 201-210.
12. Wallace, D. J., W. Stohl, R. A. Furie, J. R. Lisse, J. D. McKay, J. T. Merrill, M. A. Petri, E. M. Ginzler, W. W. Chatham, W. J. McCune, et al. 2009. A phase II, randomized, double-blind, placebo-controlled, dose-ranging study of belimumab in patients with active systemic lupus erythematosus. Arthritis Rheum. 61: 1168-1178.
13. Rauch, M., R. Tussiwand, N. Bosco, and A. G. Rolink. 2009. Crucial role for BAFF-BAFF-R signaling in the survival and maintenance of mature B cells. PLoS ONE 4: e5456.
14. Chapel, H., R. Geha, F. Rosen; IUIS PID (Primary Immunodeficiencies) Classification Committee. 2003. Primary immunodeficiency diseases: an update. Clin. Exp. Immunol. 132: 9-15. (Pubitemid 36418900)
15. Cunningham-Rundles, C., and C. Bodian. 1999. Common variable immunodeficiency: clinical and immunological features of 248 patients. Clin. Immunol. 92: 34-48. (Pubitemid 29315984)
16. Knight, A. K., L. Radigan, T. Marron, A. Langs, L. Zhang, and C. Cunningham-Rundles. 2007. High serum levels of BAFF, APRIL, and TACI in common variable immunodeficiency. Clin. Immunol. 124: 182-189. (Pubitemid 47059040)
17. Jin, R., H. Kaneko, H. Suzuki, T. Arai, T. Teramoto, T. Fukao, and N. Kondo. 2008. Age-related changes in BAFF and APRIL profiles and upregulation of BAFF and APRIL expression in patients with primary antibody deficiency. Int. J. Mol. Med. 21: 233-238. (Pubitemid 351222857)
18. Swee, L. K., A. Tardivel, P. Schneider, and A. Rolink. 2010. Rescue of the mature B cell compartment in BAFF-deficient mice by treatment with recombinant Fc-BAFF. Immunol. Lett. 131: 40-48.
19. Cambridge, G., W. Stohl, M. J. Leandro, T. S. Migone, D. M. Hilbert, and J. C. Edwards. 2006. Circulating levels of B lymphocyte stimulator in patients with rheumatoid arthritis following rituximab treatment: relationships with B cell depletion, circulating antibodies, and clinical relapse. Arthritis Rheum. 54: 723-732.
20. Lavie, F., C. Miceli-Richard, M. Ittah, J. Sellam, J. E. Gottenberg, and X. Mariette. 2007. Increase of B cell-activating factor of the TNF family (BAFF) after rituximab treatment: insights into a new regulating system of BAFF production. Ann. Rheum. Dis. 66: 700-703. (Pubitemid 46707145)
21. Pers, J. O., V. Devauchelle, C. Daridon, B. Bendaoud, R. Le Berre, A. Bordron, P. Hutin, Y. Renaudineau, M. Dueymes, S. Loisel, et al. 2007. BAFF-modulated repopulation of B lymphocytes in the blood and salivary glands of rituximabtreated patients with Sjögren's syndrome. Arthritis Rheum. 56: 1464-1477. (Pubitemid 46764075)
22. Fabris, M., L. Quartuccio, S. Sacco, G. De Marchi, G. Pozzato, C. Mazzaro, G. Ferraccioli, T. S. Migone, and S. De Vita. 2007. B-Lymphocyte stimulator (BLyS) up-regulation in mixed cryoglobulinaemia syndrome and hepatitis-C virus infection. Rheumatology (Oxford) 46: 37-43. (Pubitemid 44932781)
23. Moore, P. A., O. Belvedere, A. Orr, K. Pieri, D. W. LaFleur, P. Feng, D. Soppet, M. Charters, R. Gentz, D. Parmelee, et al. 1999. BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator. Science 285: 260-263. (Pubitemid 29330000)
24. Scapini, P., F. Bazzoni, and M. A. Cassatella. 2008. Regulation of B-cell-activating factor (BAFF)/B lymphocyte stimulator (BLyS) expression in human neutrophils. Immunol. Lett. 116: 1-6.
25. Fontaine, J., J. Chagnon-Choquet, H. S. Valcke, J. Poudrier, M. Roger; Montreal Primary HIV Infection and Long-Term Non-Progressor Study Groups. 2011. High expression levels of B lymphocyte stimulator (BLyS) by dendritic cells correlate with HIV-related B-cell disease progression in humans. Blood 117: 145-155.
26. Schneider, P., F. MacKay, V. Steiner, K. Hofmann, J. L. Bodmer, N. Holler, C. Ambrose, P. Lawton, S. Bixler, H. Acha-Orbea, et al. 1999. BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth. J. Exp. Med. 189: 1747-1756. (Pubitemid 29272691)
27. Nardelli, B., O. Belvedere, V. Roschke, P. A. Moore, H. S. Olsen, T. S. Migone, S. Sosnovtseva, J. A. Carrell, P. Feng, J. G. Giri, and D. M. Hilbert. 2001. Synthesis and release of B-lymphocyte stimulator from myeloid cells. Blood 97: 198-204. (Pubitemid 32061261)
28. Bossen, C., T. G. Cachero, A. Tardivel, K. Ingold, L. Willen, M. Dobles, M. L. Scott, A. Maquelin, E. Belnoue, C. A. Siegrist, et al. 2008. TACI, unlike BAFF-R, is solely activated by oligomeric BAFF and APRIL to support survival of activated B cells and plasmablasts. Blood 111: 1004-1012. (Pubitemid 351213377)
29. Bossen, C., A. Tardivel, L. Willen, C. A. Fletcher, M. Perroud, F. Beermann, A. G. Rolink, M. L. Scott, F. Mackay, and P. Schneider. 2011. Mutation of the BAFF furin cleavage site impairs B-cell homeostasis and antibody responses. Eur. J. Immunol. 41: 787-797.
30. Kim, H. M., K. S. Yu, M. E. Lee, D. R. Shin, Y. S. Kim, S. G. Paik, O. J. Yoo, H. Lee, and J. O. Lee. 2003. Crystal structure of the BAFF-BAFF-R complex and its implications for receptor activation. Nat. Struct. Biol. 10: 342-348. (Pubitemid 36523268)
31. Liu, Y., X. Hong, J. Kappler, L. Jiang, R. Zhang, L. Xu, C. H. Pan, W. E. Martin, R. C. Murphy, H. B. Shu, et al. 2003. Ligand-receptor binding revealed by the TNF family member TALL-1. Nature 423: 49-56. (Pubitemid 36569579)
32. Liu, Y., L. Xu, N. Opalka, J. Kappler, H. B. Shu, and G. Zhang. 2002. Crystal structure of sTALL-1 reveals a virus-like assembly of TNF family ligands. Cell 108: 383-394. (Pubitemid 34178402)
33. Zhukovsky, E. A., J. O. Lee, M. Villegas, C. Chan, S. Chu, and C. Mroske. 2004. TNF ligands: is TALL-1 a trimer or a virus-like cluster? Nature 427: 413-414, discussion 414.
34. Gorelik, L., K. Gilbride, M. Dobles, S. L. Kalled, D. Zandman, and M. L. Scott. 2003. Normal B cell homeostasis requires B cell activation factor production by radiation-resistant cells. J. Exp. Med. 198: 937-945. (Pubitemid 37152930)
35. Scapini, P., B. Nardelli, G. Nadali, F. Calzetti, G. Pizzolo, C. Montecucco, and M. A. Cassatella. 2003. G-CSF-stimulated neutrophils are a prominent source of functional BLyS. J. Exp. Med. 197: 297-302. (Pubitemid 36184236)
36. Toubi, E., S. Gordon, A. Kessel, I. Rosner, M. Rozenbaum, Y. Shoenfeld, and E. Zuckerman. 2006. Elevated serum B-lymphocyte activating factor (BAFF) in chronic hepatitis C virus infection: association with autoimmunity. J. Autoimmun. 27: 134-139. (Pubitemid 44528263)
37. Ittah, M., C. Miceli-Richard, P. Lebon, C. Pallier, C. Lepajolec, and X. Mariette. 2011. Induction of B cell-activating factor by viral infection is a general phenomenon, but the types of viruses and mechanisms depend on cell type. J. Innate Immun. 3: 200-207.
38. Thangarajh, M., A. Gomes, T. Masterman, J. Hillert, and P. Hjelmström. 2004. Expression of B-cell-activating factor of the TNF family (BAFF) and its receptors in multiple sclerosis. J. Neuroimmunol. 152: 183-190. (Pubitemid 38829716)
39. Krumbholz, M., U. Specks, M. Wick, S. L. Kalled, D. Jenne, and E. Meinl. 2005. BAFF is elevated in serum of patients with Wegener's granulomatosis. J. Autoimmun. 25: 298-302. (Pubitemid 41642976)
40. Krumbholz, M., D. Theil, T. Derfuss, A. Rosenwald, F. Schrader, C. M. Monoranu, S. L. Kalled, D. M. Hess, B. Serafini, F. Aloisi, et al. 2005. BAFF is produced by astrocytes and up-regulated in multiple sclerosis lesions and primary central nervous system lymphoma. J. Exp. Med. 201: 195-200. (Pubitemid 40189428)
41. Novak, A. J., R. J. Bram, N. E. Kay, and D. F. Jelinek. 2002. Aberrant expression of B-lymphocyte stimulator by B chronic lymphocytic leukemia cells: a mechanism for survival. Blood 100: 2973-2979.
42. He, B., A. Chadburn, E. Jou, E. J. Schattner, D. M. Knowles, and A. Cerutti. 2004. Lymphoma B cells evade apoptosis through the TNF family members BAFF/BLyS and APRIL. J. Immunol. 172: 3268-3279. (Pubitemid 38263719)
43. Nishio, M., T. Endo, N. Tsukada, J. Ohata, S. Kitada, J. C. Reed, N. J. Zvaifler, and T. J. Kipps. 2005. Nurselike cells express BAFF and APRIL, which can promote survival of chronic lymphocytic leukemia cells via a paracrine pathway distinct from that of SDF-1a. Blood 106: 1012-1020. (Pubitemid 41076448)
44. Novak, A. J., D. M. Grote, S. C. Ziesmer, M. P. Kline, M. K. Manske, S. Slager, T. E. Witzig, T. Shanafelt, T. G. Call, N. E. Kay, et al. 2006. Elevated serum B-lymphocyte stimulator levels in patients with familial lymphoproliferative disorders. J. Clin. Oncol. 24: 983-987. (Pubitemid 46638853)
45. Bojarska-Junak, A., I. Hus, S. Chocholska, E. Wasik-Szczepanek, M. Sieklucka, A. Dmoszyńska, and J. Roliński. 2009. BAFF and APRIL expression in B-cell chronic lymphocytic leukemia: correlation with biological and clinical features. Leuk. Res. 33: 1319-1327.
46. Molica, S., G. Digiesi, F. Mauro, R. Mirabelli, G. Cutrona, G. Vitelli, F. Morabito, F. Iuliano, R. Foà, and M. Ferrarini. 2009. Increased serum BAFF (B-cell activating factor of the TNF family) level is a peculiar feature associated with familial chronic lymphocytic leukemia. Leuk. Res. 33: 162-165.
47. Sawicka-Powierza, J., E. Jablonska, J. Kloczko, J. Piszcz, M. Garley, and W. Ratajczk-Wrona. 2011. Evaluation of TNF superfamily molecules release by neutrophils and B leukemic cells of patients with chronic B-cell lymphocytic leukemia. Neoplasma 58: 45-50.
48. Mohammadi, J., C. Liu, A. Aghamohammadi, A. Bergbreiter, L. Du, J. Lu, N. Rezaei, A. A. Amirzargar, M. Moin, U. Salzer, et al. 2009. Novel mutations in TACI (TNFRSF13B) causing common variable immunodeficiency. J. Clin. Immunol. 29: 777-785.
49. Batten, M., C. Fletcher, L. G. Ng, J. Groom, J. Wheway, Y. Laâbi, X. Xin, P. Schneider, J. Tschopp, C. R. Mackay, and F. Mackay. 2004. TNF deficiency fails to protect BAFF transgenic mice against autoimmunity and reveals a predisposition to B cell lymphoma. J. Immunol. 172: 812-822. (Pubitemid 38113737)