Loss of juxtaposition of RAG-induced immunoglobulin DNA ends is implicated in the precursor B-cell differentiation defect in NBS patients

Blood

Volumn 115, Issue 23, 2010, Pages 4770-4777

  Van Der Burg, Mirjam ^a   Pac, Malgorzata ^b   Berkowska, Magdalena A ^a   Goryluk Kozakiewicz, Bozenna ^b   Wakulinska, Anna ^b   Dembowska Baginska, Bozenna ^b   Gregorek, Hanna ^b   Barendregt, Barbara H ^a,c   Krajewska Walasek, Malgorzata ^b   Bernatowska, Ewa ^b   Van Dongen, Jacques J M ^a   Chrzanowska, Krystyna H ^b   Langerak, Anton W ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b CHILDREN'S MEMORIAL HEALTH INSTITUTE   (Poland)

^c SOPHIA CHILDREN S HOSPITAL   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CD19 ANTIGEN; GROWTH HORMONE; IMMUNOGLOBULIN; NIBRIN; CELL CYCLE PROTEIN; MULTIPROTEIN COMPLEX; NBN PROTEIN, HUMAN; NUCLEAR PROTEIN;

ADOLESCENT; ADULT; ARTICLE; B LYMPHOCYTE; B LYMPHOCYTE DIFFERENTIATION; CD3+ T LYMPHOCYTE; CHILD; CLINICAL ARTICLE; GENE REARRANGEMENT; HUMAN; IMMUNE DEFICIENCY; IMMUNOGLOBULIN GENE; INFANT; NIJMEGEN BREAKAGE SYNDROME; PRE B LYMPHOCYTE; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; SEVERE COMBINED IMMUNODEFICIENCY; T LYMPHOCYTE; CELL DIFFERENTIATION; CELL PROLIFERATION; DOUBLE STRANDED DNA BREAK; FEMALE; GENETIC RECOMBINATION; GENETICS; IMMUNOLOGY; MALE; METABOLISM; PATHOLOGY; SOMATIC HYPERMUTATION;

ADOLESCENT; ADULT; CELL CYCLE PROTEINS; CELL DIFFERENTIATION; CELL PROLIFERATION; CHILD; CHILD, PRESCHOOL; DNA BREAKS, DOUBLE-STRANDED; FEMALE; HUMANS; IMMUNOGLOBULINS; INFANT; MALE; MULTIPROTEIN COMPLEXES; NIJMEGEN BREAKAGE SYNDROME; NUCLEAR PROTEINS; PRECURSOR CELLS, B-LYMPHOID; RECOMBINATION, GENETIC; SOMATIC HYPERMUTATION, IMMUNOGLOBULIN; T-LYMPHOCYTES;

EID: 77954731256     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2009-10-250514     Document Type: Article

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