Human CD19 and CD40L deficiencies impair antibody selection and differentially affect somatic hypermutation

Journal of Allergy and Clinical Immunology

Volumn 134, Issue 1, 2014, Pages

  Van Zelm, Menno C ^a   Bartol, Sophinus J W ^a   Driessen, Gertjan J ^a   Mascart, Françoise ^b   Reisli, Ismail ^c   Franco, Jose L ^d   Wolska Kusnierz, Beata ^e   Kanegane, Hirokazu ^f   Boon, Louis ^g   Van Dongen, Jacques J M ^a   Van Der Burg, Mirjam ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b ERASME HOSPITAL   (Belgium)

^c NECMETTIN ERBAKAN UNIVERSITY   (Turkey)

^d UNIVERSIDAD DE ANTIOQUIA   (Colombia)

^e CHILDREN'S MEMORIAL HEALTH INSTITUTE   (Poland)

^f UNIVERSITY OF TOYAMA   (Japan)

^g BIOCEROS   (Netherlands)

Author keywords

autoreactivity; CD19; CD40L; immunoglobulin; selection; somatic hypermutation

Indexed keywords

CD19 ANTIBODY; CD19 ANTIGEN; CD40 LIGAND; CYTIDINE DEAMINASE; IMMUNOGLOBULIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN A1; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G2; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN M; SUPERANTIGEN; URACIL DNA GLYCOSIDASE;

ANTIBODY RESPONSE; ANTIGEN BINDING; ARTICLE; B LYMPHOCYTE ACTIVATION; BLOOD; CONTROLLED STUDY; DNA REPAIR; FLOW CYTOMETRY; GENE EXPRESSION; GENE REARRANGEMENT; HUMAN; HUMAN CELL; HUMORAL IMMUNE DEFICIENCY; IMMUNITY; MEMORY CELL; MISMATCH REPAIR; MUTATION RATE; PRIORITY JOURNAL; SOMATIC HYPERMUTATION; SOMATIC MUTATION; ADULT; B LYMPHOCYTE; CHILD; DEFICIENCY; FEMALE; GENE EXPRESSION REGULATION; GENETICS; IMMUNE DEFICIENCY; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; IMMUNOPHENOTYPING; INFANT; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; MALE; METABOLISM; MIDDLE AGED; MUTATION; PATHOLOGY; PRESCHOOL CHILD; SIGNAL TRANSDUCTION;

ADULT; ANTIGENS, CD19; B-LYMPHOCYTE SUBSETS; CD40 LIGAND; CHILD; CHILD, PRESCHOOL; CYTIDINE DEAMINASE; DNA REPAIR; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HUMANS; IMMUNOGLOBULIN A; IMMUNOGLOBULIN CLASS SWITCHING; IMMUNOGLOBULIN G; IMMUNOLOGIC DEFICIENCY SYNDROMES; IMMUNOLOGIC MEMORY; IMMUNOPHENOTYPING; INFANT; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; MALE; MIDDLE AGED; MUTATION; SIGNAL TRANSDUCTION; URACIL-DNA GLYCOSIDASE;

EID: 84903730984     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2013.11.015     Document Type: Article

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