Antibody deficiency in patients with ataxia telangiectasia is caused by disturbed B- and T-cell homeostasis and reduced immune repertoire diversity

Journal of Allergy and Clinical Immunology

Volumn 131, Issue 5, 2013, Pages

  Driessen, Gertjan J ^a   Ijspeert, Hanna ^a   Weemaes, Corry M R ^b   Haraldsson, Ásgeir ^c   Trip, Margreet ^a   Warris, Adilia ^b   Van Der Flier, Michiel ^b   Wulffraat, Nico ^d   Verhagen, Mijke M M ^b   Taylor, Malcolm A ^e   Van Zelm, Menno C ^a   Van Dongen, Jacques J M ^a   Van Deuren, Marcel ^b   Van Der Burg, Mirjam ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^c UNIVERSITY OF ICELAND   (Iceland)

^d UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^e UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

Ataxia telangiectasia; B cell subsets; class switch recombination; hypogammaglobulinemia; somatic hypermutation; T cell subsets; deleting recombination excision circle

Indexed keywords

ATM PROTEIN; CD38 ANTIGEN; COMPLEMENT COMPONENT C3D RECEPTOR; IMMUNOGLOBULIN G;

ADOLESCENT; ADULT; ARTICLE; ATAXIA TELANGIECTASIA; B LYMPHOCYTE; CELL DIVISION; CELL PROLIFERATION; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME ACTIVITY; FEMALE; HOMEOSTASIS; HUMAN; HUMORAL IMMUNE DEFICIENCY; IMMUNITY; IMMUNOGLOBULIN DEFICIENCY; LYMPHOCYTE COUNT; MALE; ONSET AGE; PRIORITY JOURNAL; SCHOOL CHILD; SOMATIC HYPERMUTATION; T LYMPHOCYTE;

EID: 84876921823     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2013.01.053     Document Type: Article

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