메뉴 건너뛰기




Volumn 30, Issue , 2015, Pages 52-59

Network dynamics in the tumor microenvironment

Author keywords

Big Data; Bioinformatics; Computational biology; Modeling; Network biology; Systems biology; Tumor microenvironment

Indexed keywords

BIOINFORMATICS; CANCER GROWTH; CANCER RESISTANCE; CANCER THERAPY; CELL INTERACTION; COMPUTER MODEL; DORMANCY; DRUG TARGETING; HIGH THROUGHPUT SCREENING; HUMAN; MATHEMATICAL MODEL; MOLECULAR MODEL; NETWORK DYNAMICS; REVIEW; SYSTEMS BIOLOGY; TUMOR MICROENVIRONMENT; CHEMICAL STRUCTURE; NEOPLASM; PATHOLOGY; PHYSIOLOGY;

EID: 84919634618     PISSN: 1044579X     EISSN: 10963650     Source Type: Journal    
DOI: 10.1016/j.semcancer.2014.02.007     Document Type: Review
Times cited : (40)

References (76)
  • 1
    • 79953158399 scopus 로고    scopus 로고
    • Exploring the genomes of cancer cells: progress and promise
    • Stratton M.R. Exploring the genomes of cancer cells: progress and promise. Science 2011, 331:1553-1558.
    • (2011) Science , vol.331 , pp. 1553-1558
    • Stratton, M.R.1
  • 2
    • 84863110695 scopus 로고    scopus 로고
    • The mesenchymal tumor microenvironment: a drug-resistant niche
    • Cukierman E., Bassi D.E. The mesenchymal tumor microenvironment: a drug-resistant niche. Cell Adh Migr 2012, 6:285-296.
    • (2012) Cell Adh Migr , vol.6 , pp. 285-296
    • Cukierman, E.1    Bassi, D.E.2
  • 3
    • 69249087671 scopus 로고    scopus 로고
    • Environment-mediated drug resistance: a major contributor to minimal residual disease
    • Meads M.B., Gatenby R.A., Dalton W.S. Environment-mediated drug resistance: a major contributor to minimal residual disease. Nat Rev Cancer 2009, 9:665-674.
    • (2009) Nat Rev Cancer , vol.9 , pp. 665-674
    • Meads, M.B.1    Gatenby, R.A.2    Dalton, W.S.3
  • 4
    • 56749107194 scopus 로고    scopus 로고
    • The tumor microenvironment and its contribution to tumor evolution toward metastasis
    • Lorusso G., Ruegg C. The tumor microenvironment and its contribution to tumor evolution toward metastasis. Histochem Cell Biol 2008, 130:1091-1103.
    • (2008) Histochem Cell Biol , vol.130 , pp. 1091-1103
    • Lorusso, G.1    Ruegg, C.2
  • 5
    • 58149345546 scopus 로고    scopus 로고
    • Co-evolution of tumor cells and their microenvironment
    • Polyak K., Haviv I., Campbell I.G. Co-evolution of tumor cells and their microenvironment. Trends Genet 2009, 25:30-38.
    • (2009) Trends Genet , vol.25 , pp. 30-38
    • Polyak, K.1    Haviv, I.2    Campbell, I.G.3
  • 6
    • 79952392467 scopus 로고    scopus 로고
    • Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression
    • Bissell M.J., Hines W.C. Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression. Nat Med 2011, 17:320-329.
    • (2011) Nat Med , vol.17 , pp. 320-329
    • Bissell, M.J.1    Hines, W.C.2
  • 7
    • 79954623572 scopus 로고    scopus 로고
    • The tissue organization field theory of cancer: a testable replacement for the somatic mutation theory
    • Soto A.M., Sonnenschein C. The tissue organization field theory of cancer: a testable replacement for the somatic mutation theory. Bioessays 2011, 33:332-340.
    • (2011) Bioessays , vol.33 , pp. 332-340
    • Soto, A.M.1    Sonnenschein, C.2
  • 10
    • 84866665390 scopus 로고    scopus 로고
    • Mitochondria and cancer
    • Wallace D.C. Mitochondria and cancer. Nat Rev Cancer 2012, 12:685-698.
    • (2012) Nat Rev Cancer , vol.12 , pp. 685-698
    • Wallace, D.C.1
  • 11
    • 79954536472 scopus 로고    scopus 로고
    • IL-25 causes apoptosis of IL-25R-expressing breast cancer cells without toxicity to nonmalignant cells
    • 78ra31
    • Furuta S., Jeng Y.M., Zhou L., Huang L., Kuhn I., Bissell M.J., et al. IL-25 causes apoptosis of IL-25R-expressing breast cancer cells without toxicity to nonmalignant cells. Sci Transl Med 2011, 3:78ra31.
    • (2011) Sci Transl Med , vol.3
    • Furuta, S.1    Jeng, Y.M.2    Zhou, L.3    Huang, L.4    Kuhn, I.5    Bissell, M.J.6
  • 12
    • 84864955960 scopus 로고    scopus 로고
    • Understanding the role of stromal fibroblasts in cancer progression
    • Tripathi M., Billet S., Bhowmick N.A. Understanding the role of stromal fibroblasts in cancer progression. Cell Adh Migr 2012, 6:231-235.
    • (2012) Cell Adh Migr , vol.6 , pp. 231-235
    • Tripathi, M.1    Billet, S.2    Bhowmick, N.A.3
  • 13
    • 84877264330 scopus 로고    scopus 로고
    • The role of the tumor microenvironment in regulating angiogenesis
    • Watnick R.S. The role of the tumor microenvironment in regulating angiogenesis. Cold Spring Harb Perspect Med 2012, 2:a006676.
    • (2012) Cold Spring Harb Perspect Med , vol.2 , pp. a006676
    • Watnick, R.S.1
  • 14
    • 84886698315 scopus 로고    scopus 로고
    • Innate and adaptive immune cells in the tumor microenvironment
    • Gajewski T.F., Schreiber H., Fu Y.X. Innate and adaptive immune cells in the tumor microenvironment. Nat Immunol 2013, 14:1014-1022.
    • (2013) Nat Immunol , vol.14 , pp. 1014-1022
    • Gajewski, T.F.1    Schreiber, H.2    Fu, Y.X.3
  • 15
    • 84892909254 scopus 로고    scopus 로고
    • Increased sugar uptake promotes oncogenesis via EPAC/RAP1 and O-GlcNAc pathways
    • Onodera Y., Nam J.M., Bissell M.J. Increased sugar uptake promotes oncogenesis via EPAC/RAP1 and O-GlcNAc pathways. J Clin Invest 2014, 124:367-384.
    • (2014) J Clin Invest , vol.124 , pp. 367-384
    • Onodera, Y.1    Nam, J.M.2    Bissell, M.J.3
  • 16
    • 84890149662 scopus 로고    scopus 로고
    • NFkB disrupts tissue polarity in 3D by preventing integration of microenvironmental signals
    • Becker-Weimann S., Xiong G., Furuta S., Han J., Kuhn I., Akavia U.D., et al. NFkB disrupts tissue polarity in 3D by preventing integration of microenvironmental signals. Oncotarget 2013, 4:2010-2020.
    • (2013) Oncotarget , vol.4 , pp. 2010-2020
    • Becker-Weimann, S.1    Xiong, G.2    Furuta, S.3    Han, J.4    Kuhn, I.5    Akavia, U.D.6
  • 17
    • 74049122828 scopus 로고    scopus 로고
    • Cancer systems biology: a network modeling perspective
    • Kreeger P.K., Lauffenburger D.A. Cancer systems biology: a network modeling perspective. Carcinogenesis 2010, 31:2-8.
    • (2010) Carcinogenesis , vol.31 , pp. 2-8
    • Kreeger, P.K.1    Lauffenburger, D.A.2
  • 18
    • 84891117850 scopus 로고    scopus 로고
    • Modeling the mechanics of cancer: effect of changes in cellular and extra-cellular mechanical properties
    • Katira P., Bonnecaze R.T., Zaman M.H. Modeling the mechanics of cancer: effect of changes in cellular and extra-cellular mechanical properties. Front Oncol 2013, 3:145.
    • (2013) Front Oncol , vol.3 , pp. 145
    • Katira, P.1    Bonnecaze, R.T.2    Zaman, M.H.3
  • 19
    • 84872318735 scopus 로고    scopus 로고
    • Modeling extracellular matrix reorganization in 3D environments
    • Harjanto D., Zaman M.H. Modeling extracellular matrix reorganization in 3D environments. PLoS ONE 2013, 8:e52509.
    • (2013) PLoS ONE , vol.8 , pp. e52509
    • Harjanto, D.1    Zaman, M.H.2
  • 20
    • 0020456385 scopus 로고
    • How does the extracellular matrix direct gene expression
    • Bissell M.J., Hall H.G., Parry G. How does the extracellular matrix direct gene expression. J Theor Biol 1982, 99:31-68.
    • (1982) J Theor Biol , vol.99 , pp. 31-68
    • Bissell, M.J.1    Hall, H.G.2    Parry, G.3
  • 21
    • 84859355565 scopus 로고    scopus 로고
    • Complexity in the signaling network: insights from the use of targeted inhibitors in cancer therapy
    • Logue J.S., Morrison D.K. Complexity in the signaling network: insights from the use of targeted inhibitors in cancer therapy. Genes Dev 2012, 26:641-650.
    • (2012) Genes Dev , vol.26 , pp. 641-650
    • Logue, J.S.1    Morrison, D.K.2
  • 22
    • 34748866686 scopus 로고    scopus 로고
    • Signaling pathways in cancer and embryonic stem cells
    • Dreesen O., Brivanlou A.H. Signaling pathways in cancer and embryonic stem cells. Stem Cell Rev 2007, 3:7-17.
    • (2007) Stem Cell Rev , vol.3 , pp. 7-17
    • Dreesen, O.1    Brivanlou, A.H.2
  • 23
    • 79957839340 scopus 로고    scopus 로고
    • Adaptive informatics for multifactorial and high-content biological data
    • Millard B.L., Niepel M., Menden M.P., Muhlich J.L., Sorger P.K. Adaptive informatics for multifactorial and high-content biological data. Nat Methods 2011, 8:487-493.
    • (2011) Nat Methods , vol.8 , pp. 487-493
    • Millard, B.L.1    Niepel, M.2    Menden, M.P.3    Muhlich, J.L.4    Sorger, P.K.5
  • 25
    • 84885722700 scopus 로고    scopus 로고
    • Profiles of basal and stimulated receptor signaling networks predict drug response in breast cancer lines
    • Niepel M., Hafner M., Pace E.A., Chung M., Chai D.H., Zhou L., et al. Profiles of basal and stimulated receptor signaling networks predict drug response in breast cancer lines. Sci Signal 2013, 6:ra84.
    • (2013) Sci Signal , vol.6 , pp. ra84
    • Niepel, M.1    Hafner, M.2    Pace, E.A.3    Chung, M.4    Chai, D.H.5    Zhou, L.6
  • 26
    • 84855572697 scopus 로고    scopus 로고
    • Mapping in vivo signal transduction defects by phosphoproteomics
    • Stasyk T., Huber L.A. Mapping in vivo signal transduction defects by phosphoproteomics. Trends Mol Med 2012, 18:43-51.
    • (2012) Trends Mol Med , vol.18 , pp. 43-51
    • Stasyk, T.1    Huber, L.A.2
  • 27
    • 70350228452 scopus 로고    scopus 로고
    • RAS mutations affect tumor necrosis factor-induced apoptosis in colon carcinoma cells via ERK-modulatory negative and positive feedback circuits along with non-ERK pathway effects
    • Kreeger P.K., Mandhana R., Alford S.K., Haigis K.M., Lauffenburger D.A. RAS mutations affect tumor necrosis factor-induced apoptosis in colon carcinoma cells via ERK-modulatory negative and positive feedback circuits along with non-ERK pathway effects. Cancer Res 2009, 69:8191-8199.
    • (2009) Cancer Res , vol.69 , pp. 8191-8199
    • Kreeger, P.K.1    Mandhana, R.2    Alford, S.K.3    Haigis, K.M.4    Lauffenburger, D.A.5
  • 28
    • 84869502241 scopus 로고    scopus 로고
    • ChIP-seq and beyond: new and improved methodologies to detect and characterize protein-DNA interactions
    • Furey T.S. ChIP-seq and beyond: new and improved methodologies to detect and characterize protein-DNA interactions. Nat Rev Genet 2012, 13:840-852.
    • (2012) Nat Rev Genet , vol.13 , pp. 840-852
    • Furey, T.S.1
  • 29
    • 84879293921 scopus 로고    scopus 로고
    • RNAi-mediated gene function analysis in skin
    • Beronja S., Fuchs E. RNAi-mediated gene function analysis in skin. Methods Mol Biol 2013, 961:351-361.
    • (2013) Methods Mol Biol , vol.961 , pp. 351-361
    • Beronja, S.1    Fuchs, E.2
  • 30
    • 77954534273 scopus 로고    scopus 로고
    • Rapid functional dissection of genetic networks via tissue-specific transduction and RNAi in mouse embryos
    • Beronja S., Livshits G., Williams S., Fuchs E. Rapid functional dissection of genetic networks via tissue-specific transduction and RNAi in mouse embryos. Nat Med 2010, 16:821-827.
    • (2010) Nat Med , vol.16 , pp. 821-827
    • Beronja, S.1    Livshits, G.2    Williams, S.3    Fuchs, E.4
  • 31
    • 77954518306 scopus 로고    scopus 로고
    • Tumor engineering: the other face of tissue engineering
    • Ghajar C.M., Bissell M.J. Tumor engineering: the other face of tissue engineering. Tissue Eng Part A 2010, 16:2153-2156.
    • (2010) Tissue Eng Part A , vol.16 , pp. 2153-2156
    • Ghajar, C.M.1    Bissell, M.J.2
  • 32
    • 84859024362 scopus 로고    scopus 로고
    • Laser scanning-based tissue autofluorescence/fluorescence imaging (LS-TAFI), a new technique for analysis of microanatomy in whole-mount tissues
    • Mori H., Borowsky A.D., Bhat R., Ghajar C.M., Seiki M., Bissell M.J. Laser scanning-based tissue autofluorescence/fluorescence imaging (LS-TAFI), a new technique for analysis of microanatomy in whole-mount tissues. Am J Pathol 2012, 180:2249-2256.
    • (2012) Am J Pathol , vol.180 , pp. 2249-2256
    • Mori, H.1    Borowsky, A.D.2    Bhat, R.3    Ghajar, C.M.4    Seiki, M.5    Bissell, M.J.6
  • 34
    • 84965187257 scopus 로고
    • The age distribution of cancer and a multi-stage theory of carcinogenesis
    • Armitage P., Doll R. The age distribution of cancer and a multi-stage theory of carcinogenesis. Br J Cancer 1954, 8:1-12.
    • (1954) Br J Cancer , vol.8 , pp. 1-12
    • Armitage, P.1    Doll, R.2
  • 35
    • 37549013776 scopus 로고    scopus 로고
    • A microenvironmental model of carcinogenesis
    • Gatenby R.A., Gillies R.J. A microenvironmental model of carcinogenesis. Nat Rev Cancer 2008, 8:56-61.
    • (2008) Nat Rev Cancer , vol.8 , pp. 56-61
    • Gatenby, R.A.1    Gillies, R.J.2
  • 36
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan D., Weinberg R.A. Hallmarks of cancer: the next generation. Cell 2011, 144:646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 37
    • 84880364359 scopus 로고    scopus 로고
    • Tumor evolution in space: the effects of competition colonization tradeoffs on tumor invasion dynamics
    • Orlando P.A., Gatenby R.A., Brown J.S. Tumor evolution in space: the effects of competition colonization tradeoffs on tumor invasion dynamics. Front Oncol 2013, 3:45.
    • (2013) Front Oncol , vol.3 , pp. 45
    • Orlando, P.A.1    Gatenby, R.A.2    Brown, J.S.3
  • 38
    • 33751217466 scopus 로고    scopus 로고
    • Tumor morphology and phenotypic evolution driven by selective pressure from the microenvironment
    • Anderson A.R., Weaver A.M., Cummings P.T., Quaranta V. Tumor morphology and phenotypic evolution driven by selective pressure from the microenvironment. Cell 2006, 127:905-915.
    • (2006) Cell , vol.127 , pp. 905-915
    • Anderson, A.R.1    Weaver, A.M.2    Cummings, P.T.3    Quaranta, V.4
  • 39
    • 48349122161 scopus 로고    scopus 로고
    • Invasion emerges from cancer cell adaptation to competitive microenvironments: quantitative predictions from multiscale mathematical models
    • Quaranta V., Rejniak K.A., Gerlee P., Anderson A.R. Invasion emerges from cancer cell adaptation to competitive microenvironments: quantitative predictions from multiscale mathematical models. Semin Cancer Biol 2008, 18:338-348.
    • (2008) Semin Cancer Biol , vol.18 , pp. 338-348
    • Quaranta, V.1    Rejniak, K.A.2    Gerlee, P.3    Anderson, A.R.4
  • 40
    • 77958151212 scopus 로고    scopus 로고
    • Tumour-stromal interactions in acid-mediated invasion: a mathematical model
    • Martin N.K., Gaffney E.A., Gatenby R.A., Maini P.K. Tumour-stromal interactions in acid-mediated invasion: a mathematical model. J Theor Biol 2010, 267:461-470.
    • (2010) J Theor Biol , vol.267 , pp. 461-470
    • Martin, N.K.1    Gaffney, E.A.2    Gatenby, R.A.3    Maini, P.K.4
  • 41
    • 80054018075 scopus 로고    scopus 로고
    • Evolution of tumor invasiveness: the adaptive tumor microenvironment landscape model
    • Lee H.O., Silva A.S., Concilio S., Li Y.S., Slifker M., Gatenby R.A., et al. Evolution of tumor invasiveness: the adaptive tumor microenvironment landscape model. Cancer Res 2011, 71:6327-6337.
    • (2011) Cancer Res , vol.71 , pp. 6327-6337
    • Lee, H.O.1    Silva, A.S.2    Concilio, S.3    Li, Y.S.4    Slifker, M.5    Gatenby, R.A.6
  • 42
    • 84874869768 scopus 로고    scopus 로고
    • Acute and fractionated irradiation differentially modulate glioma stem cell division kinetics
    • Gao X., McDonald J.T., Hlatky L., Enderling H. Acute and fractionated irradiation differentially modulate glioma stem cell division kinetics. Cancer Res 2013, 73:1481-1490.
    • (2013) Cancer Res , vol.73 , pp. 1481-1490
    • Gao, X.1    McDonald, J.T.2    Hlatky, L.3    Enderling, H.4
  • 43
    • 77956026315 scopus 로고    scopus 로고
    • Promotion of variant human mammary epithelial cell outgrowth by ionizing radiation: an agent-based model supported by in vitro studies
    • Mukhopadhyay R., Costes S.V., Bazarov A.V., Hines W.C., Barcellos-Hoff M.H., Yaswen P. Promotion of variant human mammary epithelial cell outgrowth by ionizing radiation: an agent-based model supported by in vitro studies. Breast Cancer Res 2010, 12:R11.
    • (2010) Breast Cancer Res , vol.12 , pp. R11
    • Mukhopadhyay, R.1    Costes, S.V.2    Bazarov, A.V.3    Hines, W.C.4    Barcellos-Hoff, M.H.5    Yaswen, P.6
  • 44
    • 84890606259 scopus 로고    scopus 로고
    • Cellular potts modeling of tumor growth, tumor invasion, and tumor evolution
    • Szabo A., Merks R.M. Cellular potts modeling of tumor growth, tumor invasion, and tumor evolution. Front Oncol 2013, 3:87.
    • (2013) Front Oncol , vol.3 , pp. 87
    • Szabo, A.1    Merks, R.M.2
  • 45
    • 84874745309 scopus 로고    scopus 로고
    • A Cellular Potts Model simulating cell migration on and in matrix environments
    • Scianna M., Preziosi L., Wolf K. A Cellular Potts Model simulating cell migration on and in matrix environments. Math Biosci Eng 2013, 10:235-261.
    • (2013) Math Biosci Eng , vol.10 , pp. 235-261
    • Scianna, M.1    Preziosi, L.2    Wolf, K.3
  • 46
    • 79955030886 scopus 로고    scopus 로고
    • Multiscale modelling of vascular tumour growth in 3D: the roles of domain size and boundary conditions
    • Perfahl H., Byrne H.M., Chen T., Estrella V., Alarcon T., Lapin A., et al. Multiscale modelling of vascular tumour growth in 3D: the roles of domain size and boundary conditions. PLoS ONE 2011, 6:e14790.
    • (2011) PLoS ONE , vol.6 , pp. e14790
    • Perfahl, H.1    Byrne, H.M.2    Chen, T.3    Estrella, V.4    Alarcon, T.5    Lapin, A.6
  • 47
    • 84862768329 scopus 로고    scopus 로고
    • Predicting the effects of anti-angiogenic agents targeting specific VEGF isoforms
    • Finley S.D., Popel A.S. Predicting the effects of anti-angiogenic agents targeting specific VEGF isoforms. AAPS J 2012, 14:500-509.
    • (2012) AAPS J , vol.14 , pp. 500-509
    • Finley, S.D.1    Popel, A.S.2
  • 48
    • 84878877091 scopus 로고    scopus 로고
    • Effect of tumor microenvironment on tumor VEGF during anti-VEGF treatment: systems biology predictions
    • Finley S.D., Popel A.S. Effect of tumor microenvironment on tumor VEGF during anti-VEGF treatment: systems biology predictions. J Natl Cancer Inst 2013, 105:802-811.
    • (2013) J Natl Cancer Inst , vol.105 , pp. 802-811
    • Finley, S.D.1    Popel, A.S.2
  • 49
    • 84881377835 scopus 로고    scopus 로고
    • A hybrid model of tumor-stromal interactions in breast cancer
    • Kim Y., Othmer H.G. A hybrid model of tumor-stromal interactions in breast cancer. Bull Math Biol 2013, 75:1304-1350.
    • (2013) Bull Math Biol , vol.75 , pp. 1304-1350
    • Kim, Y.1    Othmer, H.G.2
  • 51
    • 0024240796 scopus 로고
    • A community effect in animal development
    • Gurdon J.B. A community effect in animal development. Nature 1988, 336:772-774.
    • (1988) Nature , vol.336 , pp. 772-774
    • Gurdon, J.B.1
  • 52
    • 0036901602 scopus 로고    scopus 로고
    • Modeling transcriptional regulatory networks
    • Bolouri H., Davidson E.H. Modeling transcriptional regulatory networks. Bioessays 2002, 24:1118-1129.
    • (2002) Bioessays , vol.24 , pp. 1118-1129
    • Bolouri, H.1    Davidson, E.H.2
  • 53
    • 77951208251 scopus 로고    scopus 로고
    • The gene regulatory network basis of the community effect, and analysis of a sea urchin embryo example
    • Bolouri H., Davidson E.H. The gene regulatory network basis of the community effect, and analysis of a sea urchin embryo example. Dev Biol 2010, 340:170-178.
    • (2010) Dev Biol , vol.340 , pp. 170-178
    • Bolouri, H.1    Davidson, E.H.2
  • 54
    • 84885356671 scopus 로고    scopus 로고
    • EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma
    • Fan Q.W., Cheng C.K., Gustafson W.C., Charron E., Zipper P., Wong R.A., et al. EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma. Cancer Cell 2013, 24:438-449.
    • (2013) Cancer Cell , vol.24 , pp. 438-449
    • Fan, Q.W.1    Cheng, C.K.2    Gustafson, W.C.3    Charron, E.4    Zipper, P.5    Wong, R.A.6
  • 55
    • 84873030799 scopus 로고    scopus 로고
    • Regulation of HGF expression by DeltaEGFR-mediated c-Met activation in glioblastoma cells
    • Garnett J., Chumbalkar V., Vaillant B., Gururaj A.E., Hill K.S., Latha K., et al. Regulation of HGF expression by DeltaEGFR-mediated c-Met activation in glioblastoma cells. Neoplasia 2013, 15:73-84.
    • (2013) Neoplasia , vol.15 , pp. 73-84
    • Garnett, J.1    Chumbalkar, V.2    Vaillant, B.3    Gururaj, A.E.4    Hill, K.S.5    Latha, K.6
  • 56
    • 0036645057 scopus 로고    scopus 로고
    • Platelet-derived growth factor (PDGF) autocrine signaling regulates survival and mitogenic pathways in glioblastoma cells: evidence that the novel PDGF-C and PDGF-D ligands may play a role in the development of brain tumors
    • Lokker N.A., Sullivan C.M., Hollenbach S.J., Israel M.A., Giese N.A. Platelet-derived growth factor (PDGF) autocrine signaling regulates survival and mitogenic pathways in glioblastoma cells: evidence that the novel PDGF-C and PDGF-D ligands may play a role in the development of brain tumors. Cancer Res 2002, 62:3729-3735.
    • (2002) Cancer Res , vol.62 , pp. 3729-3735
    • Lokker, N.A.1    Sullivan, C.M.2    Hollenbach, S.J.3    Israel, M.A.4    Giese, N.A.5
  • 58
    • 0033986415 scopus 로고    scopus 로고
    • Dependence of autocrine growth factor stimulation in platelet-derived growth factor-B-induced mouse brain tumor cells
    • Uhrbom L., Hesselager G., Ostman A., Nister M., Westermark B. Dependence of autocrine growth factor stimulation in platelet-derived growth factor-B-induced mouse brain tumor cells. Int J Cancer 2000, 85:398-406.
    • (2000) Int J Cancer , vol.85 , pp. 398-406
    • Uhrbom, L.1    Hesselager, G.2    Ostman, A.3    Nister, M.4    Westermark, B.5
  • 59
    • 0035425048 scopus 로고    scopus 로고
    • PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo
    • Dai C., Celestino J.C., Okada Y., Louis D.N., Fuller G.N., Holland E.C. PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo. Genes Dev 2001, 15:1913-1925.
    • (2001) Genes Dev , vol.15 , pp. 1913-1925
    • Dai, C.1    Celestino, J.C.2    Okada, Y.3    Louis, D.N.4    Fuller, G.N.5    Holland, E.C.6
  • 60
    • 79959921981 scopus 로고    scopus 로고
    • Recruited cells can become transformed and overtake PDGF-induced murine gliomas in vivo during tumor progression
    • Fomchenko E.I., Dougherty J.D., Helmy K.Y., Katz A.M., Pietras A., Brennan C., et al. Recruited cells can become transformed and overtake PDGF-induced murine gliomas in vivo during tumor progression. PLoS ONE 2011, 6:e20605.
    • (2011) PLoS ONE , vol.6 , pp. e20605
    • Fomchenko, E.I.1    Dougherty, J.D.2    Helmy, K.Y.3    Katz, A.M.4    Pietras, A.5    Brennan, C.6
  • 61
    • 84865080890 scopus 로고    scopus 로고
    • Glial progenitor cell recruitment drives aggressive glioma growth: mathematical and experimental modelling
    • Massey S.C., Assanah M.C., Lopez K.A., Canoll P., Swanson K.R. Glial progenitor cell recruitment drives aggressive glioma growth: mathematical and experimental modelling. J R Soc Interface 2012, 9:1757-1766.
    • (2012) J R Soc Interface , vol.9 , pp. 1757-1766
    • Massey, S.C.1    Assanah, M.C.2    Lopez, K.A.3    Canoll, P.4    Swanson, K.R.5
  • 62
    • 0018069488 scopus 로고
    • Growth factors produced by sarcoma virus-transformed cells
    • Todaro G.J., de Larco J.E. Growth factors produced by sarcoma virus-transformed cells. Cancer Res 1978, 38:4147-4154.
    • (1978) Cancer Res , vol.38 , pp. 4147-4154
    • Todaro, G.J.1    de Larco, J.E.2
  • 63
    • 0021958679 scopus 로고
    • Autocrine growth factors and cancer
    • Sporn M.B., Roberts A.B. Autocrine growth factors and cancer. Nature 1985, 313:745-747.
    • (1985) Nature , vol.313 , pp. 745-747
    • Sporn, M.B.1    Roberts, A.B.2
  • 64
    • 33845318922 scopus 로고    scopus 로고
    • New potential ligand-receptor signaling loops in ovarian cancer identified in multiple gene expression studies
    • Castellano G., Reid J.F., Alberti P., Carcangiu M.L., Tomassetti A., Canevari S. New potential ligand-receptor signaling loops in ovarian cancer identified in multiple gene expression studies. Cancer Res 2006, 66:10709-10719.
    • (2006) Cancer Res , vol.66 , pp. 10709-10719
    • Castellano, G.1    Reid, J.F.2    Alberti, P.3    Carcangiu, M.L.4    Tomassetti, A.5    Canevari, S.6
  • 65
    • 79960849567 scopus 로고    scopus 로고
    • Hedgehog signaling pathway regulates the growth of ovarian cancer spheroid forming cells
    • Ray A., Meng E., Reed E., Shevde L.A., Rocconi R.P. Hedgehog signaling pathway regulates the growth of ovarian cancer spheroid forming cells. Int J Oncol 2011, 39:797-804.
    • (2011) Int J Oncol , vol.39 , pp. 797-804
    • Ray, A.1    Meng, E.2    Reed, E.3    Shevde, L.A.4    Rocconi, R.P.5
  • 67
    • 58149314571 scopus 로고    scopus 로고
    • Autocrine VEGF-A/KDR loop protects epithelial ovarian carcinoma cells from anoikis
    • Sher I., Adham S.A., Petrik J., Coomber B.L. Autocrine VEGF-A/KDR loop protects epithelial ovarian carcinoma cells from anoikis. Int J Cancer 2009, 124:553-561.
    • (2009) Int J Cancer , vol.124 , pp. 553-561
    • Sher, I.1    Adham, S.A.2    Petrik, J.3    Coomber, B.L.4
  • 69
    • 84875814055 scopus 로고    scopus 로고
    • Tumor dormancy, oncogene addiction, cellular senescence, and self-renewal programs
    • Bellovin D.I., Das B., Felsher D.W. Tumor dormancy, oncogene addiction, cellular senescence, and self-renewal programs. Adv Exp Med Biol 2013, 734:91-107.
    • (2013) Adv Exp Med Biol , vol.734 , pp. 91-107
    • Bellovin, D.I.1    Das, B.2    Felsher, D.W.3
  • 70
    • 84875183611 scopus 로고    scopus 로고
    • Metastasis awakening: the challenges of targeting minimal residual cancer
    • Polzer B., Klein C.A. Metastasis awakening: the challenges of targeting minimal residual cancer. Nat Med 2013, 19:274-275.
    • (2013) Nat Med , vol.19 , pp. 274-275
    • Polzer, B.1    Klein, C.A.2
  • 71
    • 35548936833 scopus 로고    scopus 로고
    • Models, mechanisms and clinical evidence for cancer dormancy
    • Aguirre-Ghiso J.A. Models, mechanisms and clinical evidence for cancer dormancy. Nat Rev Cancer 2007, 7:834-846.
    • (2007) Nat Rev Cancer , vol.7 , pp. 834-846
    • Aguirre-Ghiso, J.A.1
  • 72
    • 84875173347 scopus 로고    scopus 로고
    • Metastasis awakening: targeting dormant cancer
    • Aguirre-Ghiso J.A., Bragado P., Sosa M.S. Metastasis awakening: targeting dormant cancer. Nat Med 2013, 19:276-277.
    • (2013) Nat Med , vol.19 , pp. 276-277
    • Aguirre-Ghiso, J.A.1    Bragado, P.2    Sosa, M.S.3
  • 73
    • 84880547779 scopus 로고    scopus 로고
    • Activation of the FGF2-FGFR1 autocrine pathway: a novel mechanism of acquired resistance to gefitinib in NSCLC cells
    • Terai H., Soejima K.N., Yasuda H., Nakayama S., Hamamoto J., Arai D., et al. Activation of the FGF2-FGFR1 autocrine pathway: a novel mechanism of acquired resistance to gefitinib in NSCLC cells. Mol Cancer Res 2013, 11(7):759-767.
    • (2013) Mol Cancer Res , vol.11 , Issue.7 , pp. 759-767
    • Terai, H.1    Soejima, K.N.2    Yasuda, H.3    Nakayama, S.4    Hamamoto, J.5    Arai, D.6
  • 74
    • 84859949610 scopus 로고    scopus 로고
    • The extracellular matrix: a dynamic niche in cancer progression
    • Lu P., Weaver V.M., Werb Z. The extracellular matrix: a dynamic niche in cancer progression. J Cell Biol 2012, 196:395-406.
    • (2012) J Cell Biol , vol.196 , pp. 395-406
    • Lu, P.1    Weaver, V.M.2    Werb, Z.3
  • 76
    • 84899926924 scopus 로고    scopus 로고
    • Modeling genomic regulatory networks with big data
    • [Accepted for publication]
    • Bolouri H. Modeling genomic regulatory networks with big data. Trends Genet 2014, [Accepted for publication].
    • (2014) Trends Genet
    • Bolouri, H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.