RAS mutations affect tumor necrosis factor-induced apoptosis in colon carcinoma cells via ERK-modulatory negative and positive feedback circuits along with non-ERK pathway effects

Cancer Research

Volumn 69, Issue 20, 2009, Pages 8191-8199

  Kreeger, Pamela K ^a   Mandhana, Roli ^a   Alford, Shannon K ^a   Haigis, Kevin M ^c,d   Lauffenburger, Douglas A ^a,b  

^a Massachusetts Institute of Technology Cambridge   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CXCL1 CHEMOKINE; I KAPPA B KINASE; INTERLEUKIN 8; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATASE; SYNAPTOPHYSIN; TRANSFORMING GROWTH FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA;

APOPTOSIS; ARTICLE; CARCINOMA CELL; CELL ACTIVATION; CELL DEATH; CELL FUNCTION; CELL LINE; CELL MUTANT; COLORECTAL CARCINOMA; CONTROLLED STUDY; CYTOKINE PRODUCTION; DYNAMICS; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GENE MUTATION; HUMAN; HUMAN CELL; INFORMATION; NEGATIVE FEEDBACK; ONCOGENE K RAS; ONCOGENE N RAS; POSITIVE FEEDBACK; PREDICTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS;

APOPTOSIS; AUTOCRINE COMMUNICATION; BLOTTING, WESTERN; CHEMOKINES; COLONIC NEOPLASMS; COMPUTATIONAL BIOLOGY; DUAL-SPECIFICITY PHOSPHATASES; ENZYME-LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEEDBACK, PHYSIOLOGICAL; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; GENES, RAS; HUMANS; MUTATION; PROTO-ONCOGENE PROTEINS; RAS PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSFORMING GROWTH FACTOR BETA; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR-ALPHA;

EID: 70350228452     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-09-1921     Document Type: Article

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