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Volumn 51, Issue 5, 2015, Pages 925-928

Oxidative regioselective amination of chromones exposes potent inhibitors of the hedgehog signaling pathway

(6) Samanta, Rajarshi a Narayan, Rishikesh a Bauer, Jonathan O b Strohmann, Carsten b Sievers, Sonja a Antonchick, Andrey P a,b

a MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY (Germany)

b TU DORTMUND UNIVERSITY (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,4 TRIAZOLE DERIVATIVE; CHROMONE DERIVATIVE; HEDGEHOG SIGNALING PATHWAY INHIBITOR; ISOFLAVONE DERIVATIVE; PROTEIN INHIBITOR; PYRROLE DERIVATIVE; SONIC HEDGEHOG PROTEIN; TRANSITION ELEMENT; UNCLASSIFIED DRUG; 2-AMINO-4-PICOLINE; PICOLINE DERIVATIVE;

AMINATION; ARTICLE; BIOLOGICAL ACTIVITY; CHEMICAL BOND; CONTROLLED STUDY; CROSS COUPLING REACTION; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG TRANSFORMATION; ELECTROPHILICITY; FEASIBILITY STUDY; HEDGEHOG SIGNALING PATHWAY; NUCLEOPHILICITY; OXIDATION; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; CHEMISTRY; DRUG EFFECTS; ENZYME SPECIFICITY; HUMAN; IC50; METABOLISM; OXIDATION REDUCTION REACTION; TUMOR CELL LINE;

CELL LINE, TUMOR; CHROMONES; HEDGEHOG PROTEINS; HUMANS; INHIBITORY CONCENTRATION 50; OXIDATION-REDUCTION; PICOLINES; SIGNAL TRANSDUCTION; SUBSTRATE SPECIFICITY;

EID: 84919625618 PISSN: 13597345 EISSN: 1364548X Source Type: Journal
DOI: 10.1039/c4cc08376h Document Type: Article

Times cited : (48)

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