Altered Chromatin Occupancy of Master Regulators Underlies Evolutionary Divergence in the Transcriptional Landscape of Erythroid Differentiation

PLoS Genetics

Volumn 10, Issue 12, 2014, Pages

  Ulirsch, Jacob C ^a,b   Lacy, Jessica N ^a,b   An, Xiuli ^c   Mohandas, Narla ^c   Mikkelsen, Tarjei S ^b,d   Sankaran, Vijay G ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^c NEW YORK BLOOD CENTER   (United States)

^d HARVARD STEM CELL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GATA 1; TRANSCRIPTION FACTOR KLF1; TRANSCRIPTION FACTOR NFE2; TRANSCRIPTION FACTOR TAL1; UNCLASSIFIED DRUG; CHROMATIN; HISTONE; PROTEIN BINDING;

ARTICLE; BINDING SITE; CELL DIFFERENTIATION; CELL MATURATION; CHROMATIN STRUCTURE; COMPARATIVE STUDY; ERYTHROBLAST; ERYTHROID CELL; ERYTHROPOIESIS; EVOLUTION; GENE EXPRESSION; GENETIC VARIABILITY; HISTONE MODIFICATION; HUMAN; MOUSE; NONHUMAN; TRANSCRIPTION REGULATION; ANIMAL; CHROMATIN; ERYTHROID PRECURSOR CELL; GENETIC EPIGENESIS; GENETIC TRANSCRIPTION; GENETICS; K562 CELL LINE; METABOLISM; MOLECULAR EVOLUTION; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; PROMOTER REGION; PROTEIN PROCESSING; SPECIES DIFFERENCE;

MUS;

ANIMALS; BASE SEQUENCE; CELL DIFFERENTIATION; CHROMATIN; CONSERVED SEQUENCE; EPIGENESIS, GENETIC; ERYTHROID PRECURSOR CELLS; ERYTHROPOIESIS; EVOLUTION, MOLECULAR; HISTONES; HUMANS; K562 CELLS; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; SPECIES SPECIFICITY; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 84919608422     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1004890     Document Type: Article

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