Cardiac fibrosis as a determinant of ventricular tachyarrhythmias

Journal of Arrhythmia

Volumn 30, Issue 6, 2014, Pages 389-394

  Morita, Norishige ^a   Mandel, William J ^b   Kobayashi, Yoshinori ^a   Karagueuzian, Hrayr S ^b  

^a TOKAI UNIVERSITY HACHIOJI HOSPITAL   (Japan)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Anti fibrotic therapy; Cardiac fibrosis; Oxidative stress; Repolarization reserve; Ventricular fibrillation

Indexed keywords

EID: 84919469728     PISSN: 18804276     EISSN: 18832148     Source Type: Journal    
DOI: 10.1016/j.joa.2013.12.008     Document Type: Review

References (51)

1. M.S. Spach, and J.P. Boineau Microfibrosis produces electrical load variations due to loss of side-to-side cell connections: a major mechanism of structural heart disease arrhythmias Pacing Clin Electrophysiol 20 1997 397 413
2. M.S. Spach, and P.C. Dolber Relating extracellular potentials and their derivatives to anisotropic propagation at a microscopic level in human cardiac muscle. Evidence for electrical uncoupling of side-to-side fiber connections with increasing age Circ Res 58 1986 356 371
3. J.M. de Bakker, F.J. van Capelle, and M.J. Janse Slow conduction in the infarcted human heart. 'Zigzag' course of activation Circulation 88 1993 915 926
4. T.J. Wu, J.J. Ong, and C. Hwang Characteristics of wave fronts during ventricular fibrillation in human hearts with dilated cardiomyopathy: role of increased fibrosis in the generation of reentry J Am Coll Cardiol 32 1998 187 196
5. J.M.T. de Bakker, R. Coronel, and S. Tasseron Ventricular tachycardia in the infarcted, Langendorff-perfused human heart: role of the arrangement of surviving cardiac fibers J Am Coll Cardiol 15 1990 1594 1607
6. M.S. Spach, F. Heidlage, and P.C. Dolber Mechanism of origin of conduction disturbances in aging human atrial bundles: experimental and model study Heart Rhythm 4 2007 175 185
7. G. Gaudesius, M. Miragoli, and S.P. Thomas Coupling of cardiac electrical activity over extended distances by fibroblasts of cardiac origin Circ Res 93 2003 421 428
8. M.S. Spach, P.C. Dolber, and J.F. Heidlage Interaction of inhomogeneities of repolarization with anisotropic propagation in dog atria. A mechanism for both preventing and initiating reentry Circ Res 65 1989 1612 1631
9. N. Ono, H. Hayashi, and A. Kawase Spontaneous atrial fibrillation initiated by triggered activity near the pulmonary veins in aged rats subjected to glycolytic inhibition Am J Physiol Heart Circ Physiol 292 2007 639 648
10. N. Morita, A.A. Sovari, and Y. Xie Increased susceptibility of aged hearts to ventricular fibrillation during oxidative stress Am J Physiol Heart Circ Physiol 297 2009 H1594 H1605
11. N. Morita, J.H. Lee, and Y. Xie Suppression of re-entrant and multifocal ventricular fibrillation by the late sodium current blocker ranolazine J Am Coll Cardiol 57 2011 366 375
12. N. Morita, J.H. Lee, and A. Bapat Glycolytic inhibition causes spontaneous ventricular fibrillation in aged hearts Am J Physiol Heart Circ Physiol 301 2011 H180 H191
13. C.S. Lin, and C.H. Pan Regulatory mechanisms of atrial fibrotic remodeling in atrial fibrillation Cell Mol Life Sci 65 2008 1489 1508
14. W.C. De Mello Beneficial effect of eplerenone on cardiac remodelling and electrical properties of the failing heart J Renin Angiotensin Aldosterone Syst 7 2006 40 46
15. A. Leask Potential therapeutic targets for cardiac fibrosis: TGFbeta, angiotensin, endothelin, CCN2, and PDGF, partners in fibroblast activation Circ Res 106 2010 1675 1680
16. J.R. Ehrlich, P. Biliczki, and S.H. Hohnloser Atrial-selective approaches for the treatment of atrial fibrillation J Am Coll Cardiol 51 2008 787 792
17. A.H. Madrid, C. Escobar, and J.M. Rebollo Angiotensin receptor blocker as adjunctive therapy for rhythm control in atrial fibrillation: results of the irbesartan-amiodarone trial Card Electrophysiol Rev 7 2003 243 246
18. T.A. Baudino, W. Carver, and W. Giles Cardiac fibroblasts: friend or foe? Am J Physiol Heart Circ Physiol 291 2006 H1015 H1026
19. K.T. Weber, and C.G. Brilla Pathological hypertrophy and cardiac interstitium. Fibrosis and renin-angiotensin-aldosterone system Circulation 83 1991 1849 1865
20. T.A. Wynn Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases J Clin Invest 117 2007 524 529
21. T. Takahashi, C. Kalka, and H. Masuda Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization Nat Med 5 1999 434 438
22. D. Orlic, J. Kajstura, and S. Chimenti Bone marrow cells regenerate infarcted myocardium Nature 410 2001 701 705
23. M. Yamamoto, G. Sobue, and K. Yamamoto Expression of mRNAs for neurotrophic factors (NGF, BDNF, NT-3, and GDNF) and their receptors (p75NGFR, trkA, trkB, and trkC) in the adult human peripheral nervous system and nonneural tissues Neurochem Res 21 1996 929 938
24. E.M. Zeisberg, O. Tarnavski, and M. Zeisberg Endothelial-to-mesenchymal transition contributes to cardiac fibrosis Nat Med 13 2007 952 961
25. A.J. Boyle, H. Shih, and J. Hwang Cardiomyopathy of aging in the mammalian heart is characterized by myocardial hypertrophy, fibrosis and a predisposition towards cardiomyocyte apoptosis and autophagy Exp Gerontol 46 2011 549 559
26. M. Eghbali, M. Eghbali, and T.F. Robinson Collagen accumulation in heart ventricles as a function of growth and aging Cardiovasc Res 23 1989 723 729
27. R.R. de Souza Aging of myocardial collagen Biogerontology 3 2002 325 335
28. T.A. Hacker, S.H. McKiernan, and P.S. Douglas Age-related changes in cardiac structure and function in Fischer 344×Brown Norway hybrid rats Am J Physiol Heart Circ Physiol 290 2006 H304 H311
29. J. Huser, Y.G. Wang, and K.A. Sheehan Functional coupling between glycolysis and excitation-contraction coupling underlies alternans in cat heart cells J Physiol 524 2000 795 806
30. 2+ release by glycolysis in cat atrial myocytes J Physiol 564 2005 697 714
31. C.A. Ward, and W.R. Giles Ionic mechanism of the effects of hydrogen peroxide in rat ventricular myocytes J Physiol 500 1997 631 642
32. + channels J Clin Invest 116 2006 3127 3138
33. Y. Song, J.C. Shryock, and S. Wagner Blocking late sodium current reduces hydrogen peroxide-induced arrhythmogenic activity and contractile dysfunction J Pharmacol Exp Ther 318 2006 214 222
34. L.H. Xie, F. Chen, and H.S. Karagueuzian Oxidative stress-induced afterdepolarizations and calmodulin kinase II signaling Circ Res 104 2009 79 86
35. S. Wagner, H.M. Ruff, and S.L. Weber Reactive oxygen species-activated Ca/calmodulin kinase II delta is required for late I(Na) augmentation leading to cellular Na and Ca overload Circ Res 108 2011 555 565
36. Y. Xie, D. Sato, and A. Garfinkel So little source, so much sink: requirements for afterdepolarizations to propagate in tissue Biophys J 99 2010 1408 1415
37. D.J. Huelsing, K.W. Spitzer, and A.E. Pollard Electrotonic suppression of early afterdepolarizations in isolated rabbit Purkinje myocytes 1 Am J Physiol Heart Circ Physiol 279 2000 H250 H259
38. J. Saiz, J.M. Ferrero Jr., and M. Monserrat Influence of electrical coupling on early afterdepolarizations in ventricular myocytes IEEE Trans Biomed Eng 46 1999 138 147
39. D. Sato, L.H. Xie, and A.A. Sovari Synchronization of chaotic early afterdepolarizations in the genesis of cardiac arrhythmias Proc Natl Acad Sci USA 106 2009 2983 2988
40. 2+ transport Circ Res 77 1995 88 97
41. M. Ogawa, N. Morita, and L. Tang Mechanisms of recurrent ventricular fibrillation in a rabbit model of pacing-induced heart failure Heart Rhythm 6 2009 784 792
42. 2+ transient: an arrhythmia trigger within pulmonary veins 1 J Am Coll Cardiol 47 2006 1196 1206
43. A. Burashnikov, and C. Antzelevitch Reinduction of atrial fibrillation immediately after termination of the arrhythmia is mediated by late phase 3 early afterdepolarization-induced triggered activity Circulation 107 2003 2355 2360
44. 2+ exchanger suppresses torsades de pointes in an intact heart model of long QT syndrome-2 and long QT syndrome-3 Heart Rhythm 5 2008 1444 1452
45. A. Bapat, T.P. Nguyen, and J.H. Lee Enhanced sensitivity of aged fibrotic hearts to angiotensin II- and hypokalemia-induced early afterdepolarizations-mediated ventricular arrhythmias Am J Physiol Heart Circ Physiol 302 2012 H2331 H2340
46. R. OHanlon, A. Grasso, and M. Roughton Prognostic significance of myocardial fibrosis in hypertrophic cardiomyopathy J Am Coll Cardiol 56 2010 867 874
47. B. Lopez, A. Gonzalez, and J. Beaumont Identification of a potential cardiac antifibrotic mechanism of torasemide in patients with chronic heart failure J Am Coll Cardiol 50 2007 859 867
48. R. Patel, S.F. Nagueh, and N. Tsybouleva Simvastatin induces regression of cardiac hypertrophy and fibrosis and improves cardiac function in a transgenic rabbit model of human hypertrophic cardiomyopathy Circulation 104 2001 317 324
49. D.T. Nguyen, C. Ding, and E. Wilson Pirfenidone mitigates left ventricular fibrosis and dysfunction after myocardial infarction and reduces arrhythmias Heart Rhythm 7 2010 1438 1445
50. K.W. Lee, T.H. Everett, and D. Rahmutula Pirfenidone prevents the development of a vulnerable substrate for atrial fibrillation in a canine model of heart failure Circulation 114 2006 1703 1712
51. X.J. Du, Q. Xu, and E. Lekgabe Reversal of cardiac fibrosis and related dysfunction by relaxin Ann N Y Acad Sci 1160 2009 278 284