Increased susceptibility of aged hearts to ventricular fibrillation during oxidative stress

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 297, Issue 5, 2009, Pages

  Morita, Norishige ^a   Sovari, Ali A ^a   Xie, Yuanfang ^a   Fishbein, Michael C ^a   Mandel, William J ^b   Garfinkel, Alan ^a   Lin, Shien Fong ^c   Chen, Peng Sheng ^c   Xie, Lai Hua ^d   Chen, Fuhua ^a   Qu, Zhilin ^a   Weiss, James N ^a   Karagueuzian, Hrayr S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

Aging; Calcium transient; Early afterdepolarization; Fibrosis; Optical mapping; Triggered activity

Indexed keywords

ACETYLCYSTEINE; CALCIUM; HYDROGEN PEROXIDE; N [2 [[N [3 (4 CHLOROPHENYL) 2 PROPENYL] N METHYLAMINO]METHYL]PHENYL] N (2 HYDROXYETHYL) 4 METHOXYBENZENESULFONAMIDE;

AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMPUTER SIMULATION; CONTROLLED STUDY; DEPOLARIZATION; DRUG EFFECT; ELECTROPHYSIOLOGY; HEART ARRHYTHMIA; HEART VENTRICLE FIBRILLATION; HEART VENTRICLE TACHYCARDIA; ISOLATION PROCEDURE; MALE; MICROELECTRODE; MUSCLE CELL; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RABBIT; RAT;

ACETYLCYSTEINE; ACTION POTENTIALS; AGE FACTORS; AGING; ANIMALS; ANTIOXIDANTS; BENZYLAMINES; CALCIUM SIGNALING; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CELL COMMUNICATION; COMPUTER SIMULATION; DISEASE MODELS, ANIMAL; ELECTROCARDIOGRAPHY; ENZYME ACTIVATION; FIBROSIS; HEART VENTRICLES; HYDROGEN PEROXIDE; MALE; MODELS, CARDIOVASCULAR; MYOCYTES, CARDIAC; OXIDANTS; OXIDATIVE STRESS; PERFUSION; PROTEIN KINASE INHIBITORS; RABBITS; RATS; RATS, INBRED F344; SULFONAMIDES; TACHYCARDIA, VENTRICULAR; TIME FACTORS; VENTRICULAR FIBRILLATION;

EID: 70350455536     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00579.2009     Document Type: Article

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