Enhanced sensitivity of aged fibrotic hearts to angiotensin II- and hypokalemia-induced early afterdepolarization-mediated ventricular arrhythmias

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 302, Issue 11, 2012, Pages

  Bapat, Aneesh ^a   Nguyen, Thao P ^a   Lee, Jong Hwan ^b   Sovari, Ali A ^a   Fishbein, Michael C ^a   Weiss, James N ^a   Karagueuzian, Hrayr S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Sungkyunkwan University School of Medicine   (South Korea)

Author keywords

Optical mapping; Triggered activity; Ventricular fibrillation

Indexed keywords

ACETYLCYSTEINE; ANGIOTENSIN II; CONNEXIN 43; N [2 [[N [3 (4 CHLOROPHENYL) 2 PROPENYL] N METHYLAMINO]METHYL]PHENYL] N (2 HYDROXYETHYL) 4 METHOXYBENZENESULFONAMIDE;

AGED; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASCENDING AORTA; BIOLOGICAL ACTIVITY; CELL ISOLATION; CONTROLLED STUDY; DISEASE PREDISPOSITION; EARLY AFTERDEPOLARIZATION; FIBROBLAST; GAP JUNCTION; GLYCOLYSIS; HEART DEPOLARIZATION; HEART ELECTROPHYSIOLOGY; HEART MUSCLE CELL; HEART MUSCLE FIBROSIS; HEART MUSCLE POTENTIAL; HEART RHYTHM; HEART VENTRICLE ARRHYTHMIA; HEART VENTRICLE FIBRILLATION; HYPOKALEMIA; MALE; MICROELECTRODE; NONHUMAN; OXIDATIVE STRESS; PATCH CLAMP; PERFUSION; PRIORITY JOURNAL; RAT; SENSITIVITY ANALYSIS; STRUCTURE ANALYSIS;

AGING; ANGIOTENSIN II; ANIMALS; ARRHYTHMIAS, CARDIAC; DISEASE MODELS, ANIMAL; FIBROSIS; HEART; HYPOKALEMIA; MALE; MYOCARDIUM; MYOCYTES, CARDIAC; NADPH OXIDASE; OXIDATIVE STRESS; PATCH-CLAMP TECHNIQUES; RATS; RATS, INBRED F344; REACTIVE OXYGEN SPECIES; VENTRICULAR FIBRILLATION;

EID: 84861782437     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00094.2012     Document Type: Article

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