Glycolytic inhibition causes spontaneous ventricular fibrillation in aged hearts

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 301, Issue 1, 2011, Pages

  Morita, Norishige ^a   Lee, Jong Hwan ^a,c   Bapat, Aneesh ^a   Fishbein, Michael C ^b   Mandel, William J ^a,d   Chen, Peng Sheng ^e   Weiss, James N ^a   Karagueuzian, Hrayr S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Sungkyunkwan University School of Medicine   (South Korea)

^d Electrocardiographic Heartbeat Organization   (United States)

^e INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Aging; Calcium cycling; Early after depolarizations; Fibrosis; Optical mapping; Triggered activity

Indexed keywords

2 [4 (2,5 DIFLUOROBENZYLOXY)PHENOXY] 5 ETHOXYANILINE; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CALCIUM ION; CONNEXIN 43; GLIBENCLAMIDE; GLUCOSE; N [2 [[N [3 (4 CHLOROPHENYL) 2 PROPENYL] N METHYLAMINO]METHYL]PHENYL] N (2 HYDROXYETHYL) 4 METHOXYBENZENESULFONAMIDE; PYRUVIC ACID; SODIUM CALCIUM EXCHANGE PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM DEPLETION; CELL ISOLATION; CONTROLLED STUDY; EPICARDIUM; EPICARDIUM MAPPING; FLUORESCENCE; GLYCOLYTIC INHIBITION; HEART AFTERDEPOLARIZATION; HEART DEPOLARIZATION; HEART MUSCLE CELL; HEART MUSCLE FIBROSIS; HEART MUSCLE POTENTIAL; HEART VENTRICLE FIBRILLATION; HEART VENTRICLE TACHYCARDIA; ISOLATED HEART; MALE; METABOLIC INHIBITION; MICROELECTRODE; NONHUMAN; PRIORITY JOURNAL; RAT; SINGLE CELL ANALYSIS;

ACTION POTENTIALS; ADENOSINE TRIPHOSPHATE; AGING; ANIMALS; ARRHYTHMIA, SINUS; CALCIUM; CALCIUM SIGNALING; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CONNEXIN 43; ELECTROPHYSIOLOGICAL PHENOMENA; ENDOCARDIUM; FIBROSIS; FLUORESCENT DYES; GLYCOLYSIS; HEART; KATP CHANNELS; MALE; MICROELECTRODES; MYOCARDIUM; OXIDATION-REDUCTION; RATS; RATS, INBRED F344; SODIUM-CALCIUM EXCHANGER; TACHYCARDIA, VENTRICULAR; VENTRICULAR FIBRILLATION;

EID: 79959884578     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00128.2011     Document Type: Article

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