Development of next-generation macromolecular drugs based on the EPR effect: Challenges and pitfalls

Expert Opinion on Drug Delivery

Volumn 12, Issue 1, 2015, Pages 53-64

  Nakamura, Hideaki ^a   Jun, Fang ^a   Maeda, Hiroshi ^a  

^a SOJO UNIVERSITY   (Japan)

Author keywords

Application of EPR effect to PDT; Augmentation of EPR effect; Barriers to tumor delivery; Enhanced permeability and retention effect of solid tumor; Macromolecular drug; Nanomedicine; Tumor selective drug delivery

Indexed keywords

ANGIOTENSIN II; ANTINEOPLASTIC AGENT; CARBON MONOXIDE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; HEME OXYGENASE 1; NANOCARRIER; NITRIC OXIDE; TUMOR NECROSIS FACTOR ALPHA; BIOMATERIAL; DRUG; MACROMOLECULE; NANOPARTICLE;

BIOCOMPATIBILITY; BLOOD VESSEL PERMEABILITY; CANCER THERAPY; DRUG ACCUMULATION; DRUG CLEARANCE; DRUG PENETRATION; DRUG RETENTION; DRUG STABILITY; ENHANCED PERMEABILITY AND RETENTION EFFECT; HUMAN; HYPERTENSION; HYPERTHERMIC THERAPY; LYMPHATIC SYSTEM; MACROMOLECULE; METASTASIS; MOLECULAR SIZE; NANOMEDICINE; NONHUMAN; PHOTODYNAMIC THERAPY; REVIEW; SURFACE CHARGE; TUMOR VASCULARIZATION; ADMINISTRATION AND DOSAGE; CAPILLARY PERMEABILITY; DRUG DELIVERY SYSTEM; DRUG EFFECTS; NEOPLASMS; PATHOLOGY; PHARMACOLOGY; PHYSIOLOGY; PROCEDURES; VASCULARIZATION;

ANTINEOPLASTIC AGENTS; BIOCOMPATIBLE MATERIALS; CAPILLARY PERMEABILITY; DRUG DELIVERY SYSTEMS; MACROMOLECULAR SUBSTANCES; NANOPARTICLES; NEOPLASMS; PHARMACEUTICAL PREPARATIONS;

EID: 84919460238     PISSN: 17425247     EISSN: 17447593     Source Type: Journal    
DOI: 10.1517/17425247.2014.955011     Document Type: Review

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