메뉴 건너뛰기




Volumn 104, Issue 7, 2013, Pages 779-789

The link between infection and cancer: Tumor vasculature, free radicals, and drug delivery to tumors via the EPR effect

Author keywords

[No Author keywords available]

Indexed keywords

FREE RADICAL; NITRIC OXIDE; PEROXYNITRITE; SUPEROXIDE; VASCULOTROPIN; XANTHINE OXIDASE; ZINOSTATIN MALEIC ACID STYRENE COPOLYMER;

EID: 84880757123     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/cas.12152     Document Type: Review
Times cited : (153)

References (116)
  • 1
    • 0001064634 scopus 로고    scopus 로고
    • Metamorphosis of neocarzinostatin to SMANCS: chemistry, pharmacology and clinical effect of the first prototype anticancer polymer therapeutic
    • Maeda H, Edo K, Ishida N, eds. Tokyo: Springer-Verlag
    • Maeda H, Konno T. Metamorphosis of neocarzinostatin to SMANCS: chemistry, pharmacology and clinical effect of the first prototype anticancer polymer therapeutic. In: Maeda H, Edo K, Ishida N, eds. Neocarzinostatin: The Past, Present, and Future of an Anticancer Drug. Tokyo: Springer-Verlag, 1997; 227-67.
    • (1997) Neocarzinostatin: The Past, Present, and Future of an Anticancer Drug , pp. 227-267
    • Maeda, H.1    Konno, T.2
  • 2
    • 0018287715 scopus 로고
    • A lipophilic derivative of neocarzinostatin. A polymer conjugation of an antitumor protein antibiotic
    • Maeda H, Takeshita J, Kanamaru R. A lipophilic derivative of neocarzinostatin. A polymer conjugation of an antitumor protein antibiotic. Int J Pept Protein Res 1979; 14: 81-7.
    • (1979) Int J Pept Protein Res , vol.14 , pp. 81-87
    • Maeda, H.1    Takeshita, J.2    Kanamaru, R.3
  • 3
    • 0021908189 scopus 로고
    • Conjugation of poly (styrene-co-maleic acid) derivatives to the antitumor protein neocarzinostatin: pronounced improvements in pharmacological properties
    • Maeda H, Ueda M, Morinaga T, Matsumoto T. Conjugation of poly (styrene-co-maleic acid) derivatives to the antitumor protein neocarzinostatin: pronounced improvements in pharmacological properties. J Med Chem 1985; 28: 455-61.
    • (1985) J Med Chem , vol.28 , pp. 455-461
    • Maeda, H.1    Ueda, M.2    Morinaga, T.3    Matsumoto, T.4
  • 4
    • 0018634183 scopus 로고
    • Antimetastatic and antitumor activity of a derivative of neocarzinostatin: an organic solvent- and water-soluble polymer-conjugated protein
    • Maeda H, Takeshita J, Kanamaru R, Sato H, Khatoh J, Sato H. Antimetastatic and antitumor activity of a derivative of neocarzinostatin: an organic solvent- and water-soluble polymer-conjugated protein. Gann 1979; 70: 601-6.
    • (1979) Gann , vol.70 , pp. 601-606
    • Maeda, H.1    Takeshita, J.2    Kanamaru, R.3    Sato, H.4    Khatoh, J.5    Sato, H.6
  • 5
    • 0022858683 scopus 로고
    • A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs
    • Matsumura Y, Maeda H. A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Cancer Res 1986; 46: 6387-92.
    • (1986) Cancer Res , vol.46 , pp. 6387-6392
    • Matsumura, Y.1    Maeda, H.2
  • 6
    • 0024839642 scopus 로고
    • Tumoritropic and lymphotropic principles of macromolecular drugs
    • Maeda H, Matsumura Y. Tumoritropic and lymphotropic principles of macromolecular drugs. Crit Rev Ther Drug Carrier Syst 1989; 6: 193-210.
    • (1989) Crit Rev Ther Drug Carrier Syst , vol.6 , pp. 193-210
    • Maeda, H.1    Matsumura, Y.2
  • 7
    • 0019948596 scopus 로고
    • In vitro mode of action, pharmacokinetics, and organ specificity of poly(maleic acid-styrene)-conjugated neocarzinostatin, SMANCS
    • Takeshita J, Maeda H, Kanamaru R. In vitro mode of action, pharmacokinetics, and organ specificity of poly(maleic acid-styrene)-conjugated neocarzinostatin, SMANCS. Gann 1982; 73: 278-84.
    • (1982) Gann , vol.73 , pp. 278-284
    • Takeshita, J.1    Maeda, H.2    Kanamaru, R.3
  • 8
    • 0021211007 scopus 로고
    • Tailor-making of protein drugs by polymer conjugation for tumor targeting: a brief review on Smancs
    • Maeda H, Matsumoto T, Konno T, Iwai K, Ueda M. Tailor-making of protein drugs by polymer conjugation for tumor targeting: a brief review on Smancs. J Protein Chem 1984; 3: 181-93.
    • (1984) J Protein Chem , vol.3 , pp. 181-193
    • Maeda, H.1    Matsumoto, T.2    Konno, T.3    Iwai, K.4    Ueda, M.5
  • 9
    • 0024235612 scopus 로고
    • Protein binding of macromolecular anticancer agent SMANCS: characterization of poly(styrene-co-maleic acid) derivatives as an albumin binding ligand
    • Kobayashi A, Oda T, Maeda H. Protein binding of macromolecular anticancer agent SMANCS: characterization of poly(styrene-co-maleic acid) derivatives as an albumin binding ligand. J Bioact Compat Polym 1988; 3: 319-33.
    • (1988) J Bioact Compat Polym , vol.3 , pp. 319-333
    • Kobayashi, A.1    Oda, T.2    Maeda, H.3
  • 10
    • 0025044026 scopus 로고
    • Enhanced intestinal absorption of a hydrophobic polymer-conjugated protein drug, smancs, in an oily formulation
    • Oka K, Miyamoto Y, Matsumura Y et al. Enhanced intestinal absorption of a hydrophobic polymer-conjugated protein drug, smancs, in an oily formulation. Pharmaceut Res 1990; 7: 852-55.
    • (1990) Pharmaceut Res , vol.7 , pp. 852-855
    • Oka, K.1    Miyamoto, Y.2    Matsumura, Y.3
  • 11
    • 0025355670 scopus 로고
    • Comparison of the cytotoxic effects of the high- and low-molecular-weight anticancer agents on multidrug-resistant Chinese hamster ovary cells in vitro
    • Miyamoto Y, Oda T, Maeda H. Comparison of the cytotoxic effects of the high- and low-molecular-weight anticancer agents on multidrug-resistant Chinese hamster ovary cells in vitro. Cancer Res 1990; 50: 1571-75.
    • (1990) Cancer Res , vol.50 , pp. 1571-1575
    • Miyamoto, Y.1    Oda, T.2    Maeda, H.3
  • 12
    • 0031959490 scopus 로고    scopus 로고
    • Early phase tumor accumulation of macromolecules: a great difference in clearance rate between tumor and normal tissues
    • Noguchi Y, Wu J, Duncan R et al. Early phase tumor accumulation of macromolecules: a great difference in clearance rate between tumor and normal tissues. Jpn J Cancer Res 1998; 89: 307-14.
    • (1998) Jpn J Cancer Res , vol.89 , pp. 307-314
    • Noguchi, Y.1    Wu, J.2    Duncan, R.3
  • 13
    • 0029039418 scopus 로고
    • Influence of molecular weight on passive tumour accumulation of a soluble macromolecular drug carrier
    • Seymour LW, Miyamoto Y, Maeda H et al. Influence of molecular weight on passive tumour accumulation of a soluble macromolecular drug carrier. Eur J Cancer 1995; 31: 766-70.
    • (1995) Eur J Cancer , vol.31 , pp. 766-770
    • Seymour, L.W.1    Miyamoto, Y.2    Maeda, H.3
  • 14
    • 0026926609 scopus 로고
    • Conjugates of anticancer agents and polymers: advantages of macromolecular therapeutics in vivo
    • Maeda H, Seymour LW, Miyamoto Y. Conjugates of anticancer agents and polymers: advantages of macromolecular therapeutics in vivo. Bioconj Chem 1992; 3: 351-62.
    • (1992) Bioconj Chem , vol.3 , pp. 351-362
    • Maeda, H.1    Seymour, L.W.2    Miyamoto, Y.3
  • 15
    • 0034000453 scopus 로고    scopus 로고
    • Tumor vascular permeability and the EPR effect in macromolecular therapeutics
    • Maeda H, Wu J, Sawa T, Matsumura Y, Hori K. Tumor vascular permeability and the EPR effect in macromolecular therapeutics. J Control Release 2000; 65: 271-84.
    • (2000) J Control Release , vol.65 , pp. 271-284
    • Maeda, H.1    Wu, J.2    Sawa, T.3    Matsumura, Y.4    Hori, K.5
  • 16
    • 0023821387 scopus 로고
    • 3]bradykinin in ascitic fluid from a patient with gastric cancer
    • 3]bradykinin in ascitic fluid from a patient with gastric cancer. J Biol Chem 1988; 263: 16051-54.
    • (1988) J Biol Chem , vol.263 , pp. 16051-16054
    • Maeda, H.1    Matsumura, Y.2    Kato, H.3
  • 17
    • 0028227005 scopus 로고
    • Enhanced vascular permeability in solid tumor is mediated by nitric oxide and inhibited by both new nitric oxide scavenger and nitric oxide synthase inhibitor
    • Maeda H, Noguchi Y, Sato K, Akaike T. Enhanced vascular permeability in solid tumor is mediated by nitric oxide and inhibited by both new nitric oxide scavenger and nitric oxide synthase inhibitor. Jpn J Cancer Res 1994; 85: 331-34.
    • (1994) Jpn J Cancer Res , vol.85 , pp. 331-334
    • Maeda, H.1    Noguchi, Y.2    Sato, K.3    Akaike, T.4
  • 19
    • 0031964923 scopus 로고    scopus 로고
    • Modulation of enhanced vascular permeability in tumors by a bradykinin antagonist, a cyclooxygenase inhibitor, and a nitric oxide scavenger
    • Wu J, Akaike T, Maeda H. Modulation of enhanced vascular permeability in tumors by a bradykinin antagonist, a cyclooxygenase inhibitor, and a nitric oxide scavenger. Cancer Res 1998; 58: 159-65.
    • (1998) Cancer Res , vol.58 , pp. 159-165
    • Wu, J.1    Akaike, T.2    Maeda, H.3
  • 20
    • 0035001708 scopus 로고    scopus 로고
    • Enhanced vascular permeability in solid tumor involving peroxynitrite and matrix metalloproteinase
    • Wu J, Akaike T, Hayashida K, Okamoto T, Okuyama A, Maeda H. Enhanced vascular permeability in solid tumor involving peroxynitrite and matrix metalloproteinase. Jpn J Cancer Res 2001; 92: 439-51.
    • (2001) Jpn J Cancer Res , vol.92 , pp. 439-451
    • Wu, J.1    Akaike, T.2    Hayashida, K.3    Okamoto, T.4    Okuyama, A.5    Maeda, H.6
  • 21
    • 0034993240 scopus 로고    scopus 로고
    • The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting
    • Maeda H. The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting. Adv Enzyme Regul 2001; 41: 189-207.
    • (2001) Adv Enzyme Regul , vol.41 , pp. 189-207
    • Maeda, H.1
  • 22
    • 0035816204 scopus 로고    scopus 로고
    • Mechanism of tumor-targeted delivery of macromolecular drugs, including the EPR effect in solid tumor and clinical overview of the prototype polymeric drug SMANCS
    • Maeda H, Sawa T, Konno T. Mechanism of tumor-targeted delivery of macromolecular drugs, including the EPR effect in solid tumor and clinical overview of the prototype polymeric drug SMANCS. J Cont Release 2001; 74: 47-61.
    • (2001) J Cont Release , vol.74 , pp. 47-61
    • Maeda, H.1    Sawa, T.2    Konno, T.3
  • 23
    • 0027385513 scopus 로고
    • Vascular permeability enhancing activity of Porphyromonas gingivalis protease in guinea pigs
    • Kaminishi H, Cho T, Itoh T et al. Vascular permeability enhancing activity of Porphyromonas gingivalis protease in guinea pigs. FEMS Microbiol Lett 1993; 114: 109-14.
    • (1993) FEMS Microbiol Lett , vol.114 , pp. 109-114
    • Kaminishi, H.1    Cho, T.2    Itoh, T.3
  • 24
    • 0028040508 scopus 로고
    • Activation of blood clotting factors by microbial proteinases
    • Kaminishi H, Hamatake H, Cho T et al. Activation of blood clotting factors by microbial proteinases. FEMS Microbiol Lett 1994; 121: 327-32.
    • (1994) FEMS Microbiol Lett , vol.121 , pp. 327-332
    • Kaminishi, H.1    Hamatake, H.2    Cho, T.3
  • 25
    • 0028968826 scopus 로고
    • Degradation of humoral host defense by Candida albicans proteinase
    • Kaminishi H, Miyaguchi H, Tamaki T et al. Degradation of humoral host defense by Candida albicans proteinase. Infect Immun 1995; 63: 984-88.
    • (1995) Infect Immun , vol.63 , pp. 984-988
    • Kaminishi, H.1    Miyaguchi, H.2    Tamaki, T.3
  • 26
    • 0021168136 scopus 로고
    • Pathogenesis of serratial infection: activation of the Hageman factor-prekallikrein cascade by serratial protease
    • Matsumoto K, Yamamoto T, Kamata R, Maeda H. Pathogenesis of serratial infection: activation of the Hageman factor-prekallikrein cascade by serratial protease. J Biochem 1984; 96: 739-49.
    • (1984) J Biochem , vol.96 , pp. 739-749
    • Matsumoto, K.1    Yamamoto, T.2    Kamata, R.3    Maeda, H.4
  • 27
    • 0021847045 scopus 로고
    • A serratial protease causes vascular permeability reaction by activation of the Hageman factor-dependent pathway in guinea pigs
    • Kamata R, Yamamoto T, Matsumoto K, Maeda H. A serratial protease causes vascular permeability reaction by activation of the Hageman factor-dependent pathway in guinea pigs. Infect Immun 1985; 48: 747-53.
    • (1985) Infect Immun , vol.48 , pp. 747-753
    • Kamata, R.1    Yamamoto, T.2    Matsumoto, K.3    Maeda, H.4
  • 28
    • 0024340635 scopus 로고
    • Activation of Hageman factor and prekallikrein and generation of kinin by various microbial proteinases
    • Molla A, Yamamoto T, Akaike T, Miyoshi S, Maeda H. Activation of Hageman factor and prekallikrein and generation of kinin by various microbial proteinases. J Biol Chem 1989; 264: 10589-94.
    • (1989) J Biol Chem , vol.264 , pp. 10589-10594
    • Molla, A.1    Yamamoto, T.2    Akaike, T.3    Miyoshi, S.4    Maeda, H.5
  • 29
    • 0029907110 scopus 로고    scopus 로고
    • Role of microbial proteases in pathogenesis
    • Maeda H. Role of microbial proteases in pathogenesis. Microbiol Immunol 1996; 40: 685-99.
    • (1996) Microbiol Immunol , vol.40 , pp. 685-699
    • Maeda, H.1
  • 30
    • 77952562433 scopus 로고    scopus 로고
    • Microbial proteinases and pathogenesis of infection
    • Creighton TE, ed. New York: John Wiley & Sons
    • Maeda H. Microbial proteinases and pathogenesis of infection. In: Creighton TE, ed. Wiley Encyclopedia of Molecular Medicine. New York: John Wiley & Sons, 2002; 4: 2663-68.
    • (2002) Wiley Encyclopedia of Molecular Medicine , vol.4 , pp. 2663-2668
    • Maeda, H.1
  • 31
    • 0027305768 scopus 로고
    • Effect of microbial and mite proteases on low and high molecular weight kininogens
    • Maruo K, Akaike T, Inada Y, Ohkubo I, Ono T, Maeda H. Effect of microbial and mite proteases on low and high molecular weight kininogens. J Biol Chem 1993; 268: 17711-15.
    • (1993) J Biol Chem , vol.268 , pp. 17711-17715
    • Maruo, K.1    Akaike, T.2    Inada, Y.3    Ohkubo, I.4    Ono, T.5    Maeda, H.6
  • 32
    • 0024151625 scopus 로고
    • Involvement of the kinin-generating cascade in enhanced vascular permeability in tumor tissue
    • Matsumura Y, Kimura M, Yamamoto T, Maeda H. Involvement of the kinin-generating cascade in enhanced vascular permeability in tumor tissue. Jpn J Cancer Res 1988; 79: 1327-34.
    • (1988) Jpn J Cancer Res , vol.79 , pp. 1327-1334
    • Matsumura, Y.1    Kimura, M.2    Yamamoto, T.3    Maeda, H.4
  • 34
    • 0024793341 scopus 로고
    • Quantification, isolation and structural determination of bradykinin and hydroxyprolyl-bradykinin in tumor ascites
    • Matsumura Y, Kimura M, Kato H, Yamamoto T, Maeda H. Quantification, isolation and structural determination of bradykinin and hydroxyprolyl-bradykinin in tumor ascites. Adv Exp Med Biol 1989; 247A: 587-92.
    • (1989) Adv Exp Med Biol , vol.247 A , pp. 587-592
    • Matsumura, Y.1    Kimura, M.2    Kato, H.3    Yamamoto, T.4    Maeda, H.5
  • 36
    • 0036498031 scopus 로고    scopus 로고
    • Identification of bradykinin receptors in clinical cancer specimens and murine tumor tissues
    • Wu J, Akaike T, Hayashida K et al. Identification of bradykinin receptors in clinical cancer specimens and murine tumor tissues. Int J Cancer 2002; 98: 29-35.
    • (2002) Int J Cancer , vol.98 , pp. 29-35
    • Wu, J.1    Akaike, T.2    Hayashida, K.3
  • 39
    • 0024375781 scopus 로고
    • Oxygen radicals in influenza-induced pathogenesis and treatment with pyran polymer-conjugated SOD
    • Oda T, Akaike T, Hamamoto T, Suzuki F, Hirano T, Maeda H. Oxygen radicals in influenza-induced pathogenesis and treatment with pyran polymer-conjugated SOD. Science 1989; 244: 974-76.
    • (1989) Science , vol.244 , pp. 974-976
    • Oda, T.1    Akaike, T.2    Hamamoto, T.3    Suzuki, F.4    Hirano, T.5    Maeda, H.6
  • 40
    • 0025193910 scopus 로고
    • - generation by xanthine oxidase of pathogenesis of influenza virus infection in mice
    • - generation by xanthine oxidase of pathogenesis of influenza virus infection in mice. J Clin Invest 1990; 85: 739-45.
    • (1990) J Clin Invest , vol.85 , pp. 739-745
    • Akaike, T.1    Ando, M.2    Oda, T.3
  • 41
    • 0026050165 scopus 로고
    • Oxygen free radicals as pathogenic molecules in viral diseases
    • Maeda H, Akaike T. Oxygen free radicals as pathogenic molecules in viral diseases. Proc Soc Exp Biol Med 1991; 198: 721-27.
    • (1991) Proc Soc Exp Biol Med , vol.198 , pp. 721-727
    • Maeda, H.1    Akaike, T.2
  • 42
    • 84880731668 scopus 로고    scopus 로고
    • Paradigm shift in microbial pathogenesis: an alternative to the Koch-Pasteur paradigm on the new millennium. In: ed. Arai S, Kurume University School of Medicine. Abstr. in the Proceedings of the 13th International Congress for Mycoplasmology; 14-19 July 2000, Fukuoka, Japan.
    • Maeda H. Paradigm shift in microbial pathogenesis: an alternative to the Koch-Pasteur paradigm on the new millennium. In: ed. Arai S, Kurume University School of Medicine. Abstr. in the Proceedings of the 13th International Congress for Mycoplasmology; 14-19 July 2000, Fukuoka, Japan.
    • Maeda, H.1
  • 43
    • 0029958972 scopus 로고    scopus 로고
    • Pathogenesis of influenza virus-induced pneumonia: involvement of both nitric oxide and oxygen radicals
    • Akaike T, Noguchi Y, Ijiri S et al. Pathogenesis of influenza virus-induced pneumonia: involvement of both nitric oxide and oxygen radicals. Proc Natl Acad Sci USA 1996; 93: 2448-53.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 2448-2453
    • Akaike, T.1    Noguchi, Y.2    Ijiri, S.3
  • 44
    • 3543111961 scopus 로고    scopus 로고
    • Nitric oxide as an endogenous mutagen for Sendai virus without antiviral activity
    • Yoshitake J, Akaike T, Akuta T et al. Nitric oxide as an endogenous mutagen for Sendai virus without antiviral activity. J Virol 2004; 78: 8709-19.
    • (2004) J Virol , vol.78 , pp. 8709-8719
    • Yoshitake, J.1    Akaike, T.2    Akuta, T.3
  • 45
    • 0033653531 scopus 로고    scopus 로고
    • Nitric oxide and virus infection
    • Akaike T, Maeda H. Nitric oxide and virus infection. Immunology 2000; 101: 300-8.
    • (2000) Immunology , vol.101 , pp. 300-308
    • Akaike, T.1    Maeda, H.2
  • 46
    • 0002217831 scopus 로고    scopus 로고
    • Pathophysiological effects of high-output production of nitric oxide
    • Ignarro LJ, ed. San Diego: Academic Press
    • Akaike T, Maeda H. Pathophysiological effects of high-output production of nitric oxide. In: Ignarro LJ, ed. Nitric Oxide. San Diego: Academic Press, 2000; 733-45.
    • (2000) Nitric Oxide , pp. 733-745
    • Akaike, T.1    Maeda, H.2
  • 47
    • 0037457876 scopus 로고    scopus 로고
    • 8-Nitroguanosine formation in viral pneumonia and its implication for pathogenesis
    • Akaike T, Okamoto S, Sawa T et al. 8-Nitroguanosine formation in viral pneumonia and its implication for pathogenesis. Proc Natl Acad Sci USA 2003; 100: 685-90.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 685-690
    • Akaike, T.1    Okamoto, S.2    Sawa, T.3
  • 48
    • 17544375439 scopus 로고    scopus 로고
    • Viral mutation accelerated by nitric oxide production during infection in vivo
    • Akaike T, Fujii S, Kato A et al. Viral mutation accelerated by nitric oxide production during infection in vivo. FASEB J 2000; 14: 1447-54.
    • (2000) FASEB J , vol.14 , pp. 1447-1454
    • Akaike, T.1    Fujii, S.2    Kato, A.3
  • 49
    • 61749098693 scopus 로고    scopus 로고
    • Generation of drug-resistant mutants of Helicobacter pylori in the presence of peroxynitrite, a derivative of nitric oxide, at pathophysiological concentration
    • Kuwahara H, Kariu T, Fan J, Maeda H. Generation of drug-resistant mutants of Helicobacter pylori in the presence of peroxynitrite, a derivative of nitric oxide, at pathophysiological concentration. Microbiol Immunol 2009; 52: 1-7.
    • (2009) Microbiol Immunol , vol.52 , pp. 1-7
    • Kuwahara, H.1    Kariu, T.2    Fan, J.3    Maeda, H.4
  • 50
    • 3142581964 scopus 로고    scopus 로고
    • Antioxidative and antimutagenic activities of 4-vinyl-2,6-dimethoxyphenol (canolol) isolated from canola oil
    • Kuwahara H, Kanazawa A, Wakamatsu D et al. Antioxidative and antimutagenic activities of 4-vinyl-2, 6-dimethoxyphenol (canolol) isolated from canola oil. J Agric Food Chem 2004; 52: 4380-87.
    • (2004) J Agric Food Chem , vol.52 , pp. 4380-4387
    • Kuwahara, H.1    Kanazawa, A.2    Wakamatsu, D.3
  • 51
    • 39649110371 scopus 로고    scopus 로고
    • 4-Vinyl-2,6-dimethoxyphenol (canolol) suppresses oxidative stress and gastric carcinogenesis in Helicobacter pylori-infected carcinogen-treated Mongolian gerbils
    • Cao X, Tsukamoto T, Seki T et al. 4-Vinyl-2, 6-dimethoxyphenol (canolol) suppresses oxidative stress and gastric carcinogenesis in Helicobacter pylori-infected carcinogen-treated Mongolian gerbils. Int J Cancer 2008; 122: 1445-54.
    • (2008) Int J Cancer , vol.122 , pp. 1445-1454
    • Cao, X.1    Tsukamoto, T.2    Seki, T.3
  • 52
    • 0032121445 scopus 로고    scopus 로고
    • Nitric oxide and oxygen radicals in infection, inflammation, and cancer
    • Maeda H, Akaike T. Nitric oxide and oxygen radicals in infection, inflammation, and cancer. Biochemistry (Moscow) 1998; 63: 1007-17.
    • (1998) Biochemistry (Moscow) , vol.63 , pp. 1007-1017
    • Maeda, H.1    Akaike, T.2
  • 53
    • 0242362832 scopus 로고    scopus 로고
    • Superoxide generation mediated by 8-nitroguanosine, a highly redox-active nucleic acid derivative
    • Sawa T, Akaike T, Ichimori K et al. Superoxide generation mediated by 8-nitroguanosine, a highly redox-active nucleic acid derivative. Biochem Biophys Res Commun 2003; 311: 300-6.
    • (2003) Biochem Biophys Res Commun , vol.311 , pp. 300-306
    • Sawa, T.1    Akaike, T.2    Ichimori, K.3
  • 54
    • 0027082321 scopus 로고
    • Evidence of direct generation of oxygen free radicals from heterocyclic amines by NADPH/cytochrome P-450 reductase in vitro
    • Sato K, Akaike T, Kojima Y, Ando M, Nagao M, Maeda H. Evidence of direct generation of oxygen free radicals from heterocyclic amines by NADPH/cytochrome P-450 reductase in vitro. Jpn J Cancer Res 1992; 83: 1204-9.
    • (1992) Jpn J Cancer Res , vol.83 , pp. 1204-1209
    • Sato, K.1    Akaike, T.2    Kojima, Y.3    Ando, M.4    Nagao, M.5    Maeda, H.6
  • 55
    • 0028597512 scopus 로고
    • Generation of free radicals from neocarzinostatin mediated by NADPH/cytochrome P-450 reductase via activation of enediyne chromophore
    • Sato K, Akaike T, Suga M, Ando M, Maeda H. Generation of free radicals from neocarzinostatin mediated by NADPH/cytochrome P-450 reductase via activation of enediyne chromophore. Biochem Biophys Res Commun 1994; 205: 1716-23.
    • (1994) Biochem Biophys Res Commun , vol.205 , pp. 1716-1723
    • Sato, K.1    Akaike, T.2    Suga, M.3    Ando, M.4    Maeda, H.5
  • 56
    • 0036330695 scopus 로고    scopus 로고
    • Dietary lipid peroxidation products and DNA damage in colon carcinogenesis
    • Kanazawa A, Sawa T, Akaike T, Maeda H. Dietary lipid peroxidation products and DNA damage in colon carcinogenesis. Eur J Lipid Sci Technol 2002; 104: 439-47.
    • (2002) Eur J Lipid Sci Technol , vol.104 , pp. 439-447
    • Kanazawa, A.1    Sawa, T.2    Akaike, T.3    Maeda, H.4
  • 57
    • 0029420932 scopus 로고
    • Superoxide radical generation from heterocyclic amines
    • Adamson RH, Gustafsson JA, Ito N eds. Proceedings of the 23rd International Symposium of the Princess Takamatsu Cancer Research Fund, Tokyo. Princeton, NJ: Princeton Scientific Publishing Co.
    • Maeda H, Sato K, Akaike T. Superoxide radical generation from heterocyclic amines. In: Adamson RH, Gustafsson JA, Ito N et al. eds. Heterocyclic Amines in Cooked Foods: Possible Human Carcinogens. Proceedings of the 23rd International Symposium of the Princess Takamatsu Cancer Research Fund, Tokyo. Princeton, NJ: Princeton Scientific Publishing Co., 1995; 103-12.
    • (1995) Heterocyclic Amines in Cooked Foods: Possible Human Carcinogens , pp. 103-112
    • Maeda, H.1    Sato, K.2    Akaike, T.3
  • 58
    • 31544432817 scopus 로고    scopus 로고
    • Peroxynitrite-induced oxidation and nitration products of guanine and 8-oxoguanine: structures and mechanisms of product formation
    • Niles JC, Wishnok JS, Tannenbaum SR. Peroxynitrite-induced oxidation and nitration products of guanine and 8-oxoguanine: structures and mechanisms of product formation. Nitric Oxide 2006; 14: 109-21.
    • (2006) Nitric Oxide , vol.14 , pp. 109-121
    • Niles, J.C.1    Wishnok, J.S.2    Tannenbaum, S.R.3
  • 59
    • 31544453292 scopus 로고    scopus 로고
    • Nitrative DNA damage in inflammation and its possible role in carcinogenesis
    • Sawa T, Ohshima H. Nitrative DNA damage in inflammation and its possible role in carcinogenesis. Nitric Oxide 2006; 14: 91-100.
    • (2006) Nitric Oxide , vol.14 , pp. 91-100
    • Sawa, T.1    Ohshima, H.2
  • 60
    • 0032904734 scopus 로고    scopus 로고
    • Inflammatory cell-mediated tumour progression and minisatellite mutation correlate with the decrease of antioxidative enzymes in murine fibrosarcoma cells
    • Okada F, Nakai K, Kobayashi T et al. Inflammatory cell-mediated tumour progression and minisatellite mutation correlate with the decrease of antioxidative enzymes in murine fibrosarcoma cells. Br J Cancer 1999; 79: 377-85.
    • (1999) Br J Cancer , vol.79 , pp. 377-385
    • Okada, F.1    Nakai, K.2    Kobayashi, T.3
  • 61
    • 33745700697 scopus 로고    scopus 로고
    • The role of nicotinamide adenine dinucleotide phosphate oxidase-derived reactive oxygen species in the acquisition of metastatic ability of tumor cells
    • Okada F, Kobayashi M, Tanaka H et al. The role of nicotinamide adenine dinucleotide phosphate oxidase-derived reactive oxygen species in the acquisition of metastatic ability of tumor cells. Am J Pathol 2006; 169: 294-302.
    • (2006) Am J Pathol , vol.169 , pp. 294-302
    • Okada, F.1    Kobayashi, M.2    Tanaka, H.3
  • 62
    • 31544469761 scopus 로고    scopus 로고
    • Involvement of reactive nitrogen oxides for acquisition of metastatic properties of benign tumors in a model of inflammation-based tumor progression
    • Okada F, Tazawa H, Kobayashi T, Kobayashi M, Hosokawa M. Involvement of reactive nitrogen oxides for acquisition of metastatic properties of benign tumors in a model of inflammation-based tumor progression. Nitric Oxide 2006; 14: 122-9.
    • (2006) Nitric Oxide , vol.14 , pp. 122-129
    • Okada, F.1    Tazawa, H.2    Kobayashi, T.3    Kobayashi, M.4    Hosokawa, M.5
  • 63
    • 35648972647 scopus 로고    scopus 로고
    • Beyond foreign-body-induced carcinogenesis: impact of reactive oxygen species derived from inflammatory cells in tumorigenic conversion and tumor progression
    • Okada F. Beyond foreign-body-induced carcinogenesis: impact of reactive oxygen species derived from inflammatory cells in tumorigenic conversion and tumor progression. Int J Cancer 2007; 121: 2364-72.
    • (2007) Int J Cancer , vol.121 , pp. 2364-2372
    • Okada, F.1
  • 64
    • 84863331610 scopus 로고    scopus 로고
    • Inflammation-mediated genomic instability: roles of activation-induced cytidine deaminase in carcinogenesis
    • Shimizu T, Marusawa H, Endo Y, Chiba T. Inflammation-mediated genomic instability: roles of activation-induced cytidine deaminase in carcinogenesis. Cancer Sci 2012; 103: 1201-6.
    • (2012) Cancer Sci , vol.103 , pp. 1201-1206
    • Shimizu, T.1    Marusawa, H.2    Endo, Y.3    Chiba, T.4
  • 65
    • 5844370499 scopus 로고    scopus 로고
    • Prevention of second primary tumors by an acyclic retinoid, polyprenoic acid, in patients with hepatocellular carcinoma. Hepatoma Prevention Study Group
    • Muto Y, Moriwaki H, Ninomiya M et al. Prevention of second primary tumors by an acyclic retinoid, polyprenoic acid, in patients with hepatocellular carcinoma. Hepatoma Prevention Study Group. N Engl J Med 1996; 334: 1561-67.
    • (1996) N Engl J Med , vol.334 , pp. 1561-1567
    • Muto, Y.1    Moriwaki, H.2    Ninomiya, M.3
  • 66
    • 0035138434 scopus 로고    scopus 로고
    • Inhibition of azoxymethane-induced colon carcinogenesis in male F344 rats by the citrus limonoids obacunone and limonin
    • Tanaka T, Maeda M, Kohno H et al. Inhibition of azoxymethane-induced colon carcinogenesis in male F344 rats by the citrus limonoids obacunone and limonin. Carcinogenesis 2001; 22: 193-98.
    • (2001) Carcinogenesis , vol.22 , pp. 193-198
    • Tanaka, T.1    Maeda, M.2    Kohno, H.3
  • 67
    • 0142166328 scopus 로고    scopus 로고
    • Cancer chemoprevention with dietary phytochemicals
    • Surh YJ. Cancer chemoprevention with dietary phytochemicals. Nat Rev Cancer 2003; 3: 768-80.
    • (2003) Nat Rev Cancer , vol.3 , pp. 768-780
    • Surh, Y.J.1
  • 68
    • 33845332311 scopus 로고    scopus 로고
    • New York: Garland Science, Taylor and Francis Group
    • Weinberg RA. The Biology of Cancer. New York: Garland Science, Taylor and Francis Group, 2007.
    • (2007) The Biology of Cancer
    • Weinberg, R.A.1
  • 69
    • 0035291191 scopus 로고    scopus 로고
    • SMANCS and polymer-conjugated macromolecular drugs: advantages in cancer chemotherapy
    • Maeda H. SMANCS and polymer-conjugated macromolecular drugs: advantages in cancer chemotherapy. Adv Drug Deliv Rev 2001; 46: 169-85.
    • (2001) Adv Drug Deliv Rev , vol.46 , pp. 169-185
    • Maeda, H.1
  • 70
    • 0027299899 scopus 로고
    • Augmentation of tumor delivery of macromolecular drugs with reduced bone marrow delivery by elevating blood pressure
    • Li CJ, Miyamoto Y, Kojima Y, Maeda H. Augmentation of tumor delivery of macromolecular drugs with reduced bone marrow delivery by elevating blood pressure. Br J Cancer 1993; 67: 975-80.
    • (1993) Br J Cancer , vol.67 , pp. 975-980
    • Li, C.J.1    Miyamoto, Y.2    Kojima, Y.3    Maeda, H.4
  • 71
    • 0018888153 scopus 로고
    • Selective localization and growth of Bifidobacterium bifidum in mouse tumors following intravenous administration
    • Kimura N, Taniguchi S, Aoki K, Baba T. Selective localization and growth of Bifidobacterium bifidum in mouse tumors following intravenous administration. Cancer Res 1980; 40: 2060-68.
    • (1980) Cancer Res , vol.40 , pp. 2060-2068
    • Kimura, N.1    Taniguchi, S.2    Aoki, K.3    Baba, T.4
  • 72
    • 0025255160 scopus 로고
    • Microvascular architecture of experimental colon tumors in the rat
    • Skinner SA, Tutton PJM, O'Brien PE. Microvascular architecture of experimental colon tumors in the rat. Cancer Res 1990; 50: 2411-17.
    • (1990) Cancer Res , vol.50 , pp. 2411-2417
    • Skinner, S.A.1    Tutton, P.J.M.2    O'Brien, P.E.3
  • 73
    • 77954837315 scopus 로고    scopus 로고
    • In vitro and in vivo evaluation of tumor targeting SMA-pirarubicin micelles: survival improvement and inhibition of liver metastases
    • Daruwalla J, Nikfarjam M, Greish K et al. In vitro and in vivo evaluation of tumor targeting SMA-pirarubicin micelles: survival improvement and inhibition of liver metastases. Cancer Sci 2010; 101: 1866-74.
    • (2010) Cancer Sci , vol.101 , pp. 1866-1874
    • Daruwalla, J.1    Nikfarjam, M.2    Greish, K.3
  • 74
    • 54449095986 scopus 로고    scopus 로고
    • Styrene maleic acid-pirarubicin disrupts tumor microcirculation and enhances the permeability of colorectal liver metastases
    • Daruwalla J, Greish K, Wilson C et al. Styrene maleic acid-pirarubicin disrupts tumor microcirculation and enhances the permeability of colorectal liver metastases. J Vasc Res 2009; 46: 218-28.
    • (2009) J Vasc Res , vol.46 , pp. 218-228
    • Daruwalla, J.1    Greish, K.2    Wilson, C.3
  • 75
    • 0021349643 scopus 로고
    • Use of oily contrast medium for selective drug targeting to tumor: enhanced therapeutic effect and X-ray image
    • Iwai K, Maeda H, Konno T. Use of oily contrast medium for selective drug targeting to tumor: enhanced therapeutic effect and X-ray image. Cancer Res 1984; 44: 2115-21.
    • (1984) Cancer Res , vol.44 , pp. 2115-2121
    • Iwai, K.1    Maeda, H.2    Konno, T.3
  • 76
    • 77952575335 scopus 로고    scopus 로고
    • Tumor-selective delivery of macromolecular drugs via the EPR effect: background and future prospects
    • Maeda H. Tumor-selective delivery of macromolecular drugs via the EPR effect: background and future prospects. Bioconjug Chem 2010; 21: 797-802.
    • (2010) Bioconjug Chem , vol.21 , pp. 797-802
    • Maeda, H.1
  • 77
    • 84860777658 scopus 로고    scopus 로고
    • Vascular permeability in cancer and infection as related to macromolecular drug delivery, with emphasis on the EPR effect for tumor-selective drug targeting
    • Maeda H. Vascular permeability in cancer and infection as related to macromolecular drug delivery, with emphasis on the EPR effect for tumor-selective drug targeting. Proc Jpn Acad Ser B 2012; 88: 53-71.
    • (2012) Proc Jpn Acad Ser B , vol.88 , pp. 53-71
    • Maeda, H.1
  • 78
    • 79953054576 scopus 로고    scopus 로고
    • EPR effect: the unique characteristics of tumor blood vessels for drug delivery, factors involved, its limitation and augmentation
    • Fang J, Nakamura H, Maeda H. EPR effect: the unique characteristics of tumor blood vessels for drug delivery, factors involved, its limitation and augmentation. Adv Drug Deliv Rev 2011; 63: 136-151.
    • (2011) Adv Drug Deliv Rev , vol.63 , pp. 136-151
    • Fang, J.1    Nakamura, H.2    Maeda, H.3
  • 79
    • 84873268296 scopus 로고    scopus 로고
    • The EPR effect for macromolecular drug delivery to solid tumors: improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo
    • Maeda H, Nakamura H, Fang J. The EPR effect for macromolecular drug delivery to solid tumors: improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo. Adv Drug Deliv Rev 2013; 65: 71-79.
    • (2013) Adv Drug Deliv Rev , vol.65 , pp. 71-79
    • Maeda, H.1    Nakamura, H.2    Fang, J.3
  • 81
    • 0023280718 scopus 로고
    • Tumor targeting by arterial administration of lipids: rabbit model with VX2 carcinoma in the liver
    • Iwai K, Maeda H, Konno T et al. Tumor targeting by arterial administration of lipids: rabbit model with VX2 carcinoma in the liver. Anticancer Res 1987; 7: 321-8.
    • (1987) Anticancer Res , vol.7 , pp. 321-328
    • Iwai, K.1    Maeda, H.2    Konno, T.3
  • 82
    • 0020356747 scopus 로고
    • Use of a lipid lymphographic agent, lipiodol, as a carrier of high molecular weight antitumor agent, SMANCS, for hepatocellular carcinoma
    • Japanese
    • Konno T, Maeda H, Yokoyama I et al. Use of a lipid lymphographic agent, lipiodol, as a carrier of high molecular weight antitumor agent, SMANCS, for hepatocellular carcinoma. Cancer Chemother 1982; 9: 2005-15 (in Japanese).
    • (1982) Cancer Chemother , vol.9 , pp. 2005-2015
    • Konno, T.1    Maeda, H.2    Yokoyama, I.3
  • 83
    • 0020525867 scopus 로고
    • Effect of arterial administration of high-molecular-weight anticancer agent SMANCS with lipid lymphographic agent on hepatoma: a preliminary report
    • Konno T, Maeda H, Iwai K et al. Effect of arterial administration of high-molecular-weight anticancer agent SMANCS with lipid lymphographic agent on hepatoma: a preliminary report. Eur J Cancer Clin Oncol 1983; 19: 1053-65.
    • (1983) Eur J Cancer Clin Oncol , vol.19 , pp. 1053-1065
    • Konno, T.1    Maeda, H.2    Iwai, K.3
  • 84
    • 0021687244 scopus 로고
    • Selective targeting of anti-cancer drug and simultaneous image enhancement in solid tumors by arterially administered lipid contrast medium
    • Konno T, Maeda H, Iwai K et al. Selective targeting of anti-cancer drug and simultaneous image enhancement in solid tumors by arterially administered lipid contrast medium. Cancer 1984; 54: 2367-74.
    • (1984) Cancer , vol.54 , pp. 2367-2374
    • Konno, T.1    Maeda, H.2    Iwai, K.3
  • 85
    • 0021968171 scopus 로고
    • Image enhancement in computerized tomography for sensitive diagnosis of liver cancer and semiquantitation of tumor selective drug targeting with oily contrast medium
    • Maki S, Konno T, Maeda H. Image enhancement in computerized tomography for sensitive diagnosis of liver cancer and semiquantitation of tumor selective drug targeting with oily contrast medium. Cancer 1985; 56: 751-57.
    • (1985) Cancer , vol.56 , pp. 751-757
    • Maki, S.1    Konno, T.2    Maeda, H.3
  • 86
    • 0002649813 scopus 로고
    • Targeting chemotherapy of hepatocellular carcinoma
    • Okuda K, Ishak KG, eds. Tokyo, Berlin, Heidelberg, New York: Springer-Verlag
    • Konno T, Maeda H. Targeting chemotherapy of hepatocellular carcinoma. In: Okuda K, Ishak KG, eds. Neoplasms of the Liver. Tokyo, Berlin, Heidelberg, New York: Springer-Verlag, 1987; 343-52.
    • (1987) Neoplasms of the Liver , pp. 343-352
    • Konno, T.1    Maeda, H.2
  • 87
    • 0025973522 scopus 로고
    • Tumor-targeted chemotherapy with lipid contrast medium and macromolecular anticancer drug (SMANCS) for renal cell carcinoma
    • Kobayashi M, Imai K, Sugihara S, Maeda H, Konno T, Yamanaka H. Tumor-targeted chemotherapy with lipid contrast medium and macromolecular anticancer drug (SMANCS) for renal cell carcinoma. Urology 1991; 37: 288-94.
    • (1991) Urology , vol.37 , pp. 288-294
    • Kobayashi, M.1    Imai, K.2    Sugihara, S.3    Maeda, H.4    Konno, T.5    Yamanaka, H.6
  • 88
    • 0034099397 scopus 로고    scopus 로고
    • Long-term survival rate after tumor-targeted chemotherapy with the macromolecular anticancer drug SMANCS in lipid contrast medium for renal cell carcinoma: preoperative therapy for nonmetastatic cases
    • Tsuchiya K, Uchida T, Kobayashi M. Long-term survival rate after tumor-targeted chemotherapy with the macromolecular anticancer drug SMANCS in lipid contrast medium for renal cell carcinoma: preoperative therapy for nonmetastatic cases. Urology 2000; 55: 495-500.
    • (2000) Urology , vol.55 , pp. 495-500
    • Tsuchiya, K.1    Uchida, T.2    Kobayashi, M.3
  • 89
    • 70449374917 scopus 로고    scopus 로고
    • Elevating blood pressure as a strategy to increase tumor targeted delivery of macromolecular drug SMANCS: cases of advanced solid tumors
    • Nagamitsu A, Greish K, Maeda H. Elevating blood pressure as a strategy to increase tumor targeted delivery of macromolecular drug SMANCS: cases of advanced solid tumors. Jpn J Clin Oncol 2009; 39: 756-66.
    • (2009) Jpn J Clin Oncol , vol.39 , pp. 756-766
    • Nagamitsu, A.1    Greish, K.2    Maeda, H.3
  • 90
    • 84869496799 scopus 로고    scopus 로고
    • Macromolecular therapeutics in cancer treatment: the EPR effect and beyond
    • Maeda H. Macromolecular therapeutics in cancer treatment: the EPR effect and beyond. J Control Release 2012; 164: 138-44.
    • (2012) J Control Release , vol.164 , pp. 138-144
    • Maeda, H.1
  • 91
    • 0029551759 scopus 로고
    • Microvascular corrosion casting in the study of tumor vascularity: a review
    • Konerding MA, Miodonski AJ, Lametschwandtner A. Microvascular corrosion casting in the study of tumor vascularity: a review. Scanning Microsc 1995; 9: 1233-44.
    • (1995) Scanning Microsc , vol.9 , pp. 1233-1244
    • Konerding, M.A.1    Miodonski, A.J.2    Lametschwandtner, A.3
  • 92
    • 0033839080 scopus 로고    scopus 로고
    • Openings between defective endothelial cells explain tumor vessel leakiness
    • Hashizume H, Baluk P, Morikawa S et al. Openings between defective endothelial cells explain tumor vessel leakiness. Am J Pathol 2000; 1561: 1363-80.
    • (2000) Am J Pathol , vol.1561 , pp. 1363-1380
    • Hashizume, H.1    Baluk, P.2    Morikawa, S.3
  • 93
    • 0037334516 scopus 로고    scopus 로고
    • Vascular permeability enhancement in solid tumor: various factors, mechanisms involved and its implications
    • Maeda H, Fang J, Inuzuka T, Kitamoto Y. Vascular permeability enhancement in solid tumor: various factors, mechanisms involved and its implications. Int Immunopharmacol 2003; 3: 319-28.
    • (2003) Int Immunopharmacol , vol.3 , pp. 319-328
    • Maeda, H.1    Fang, J.2    Inuzuka, T.3    Kitamoto, Y.4
  • 96
    • 70649088695 scopus 로고    scopus 로고
    • Enhanced delivery of macromolecular antitumor drugs to tumors by nitroglycerin application
    • Seki T, Fang J, Maeda H. Enhanced delivery of macromolecular antitumor drugs to tumors by nitroglycerin application. Cancer Sci 2009; 100: 2426-30.
    • (2009) Cancer Sci , vol.100 , pp. 2426-2430
    • Seki, T.1    Fang, J.2    Maeda, H.3
  • 97
    • 84874098069 scopus 로고    scopus 로고
    • Carbon monoxide, generated by heme oxygenase-1, mediates the enhanced permeability and retention (EPR) effect of solid tumor
    • Fang J, Qin H, Nakamura H, Tsukigawa K, Shin T, Maeda H. Carbon monoxide, generated by heme oxygenase-1, mediates the enhanced permeability and retention (EPR) effect of solid tumor. Cancer Sci 2012; 102: 535-41.
    • (2012) Cancer Sci , vol.102 , pp. 535-541
    • Fang, J.1    Qin, H.2    Nakamura, H.3    Tsukigawa, K.4    Shin, T.5    Maeda, H.6
  • 98
    • 33644838950 scopus 로고    scopus 로고
    • Randomized phase II trial comparing nitroglycerin plus vinorelbine and cisplatin with vinorelbine and cisplatin alone in previously untreated stage IIIB/IV non-small cell lung cancer
    • Yasuda H, Yamaya M, Nakayama K et al. Randomized phase II trial comparing nitroglycerin plus vinorelbine and cisplatin with vinorelbine and cisplatin alone in previously untreated stage IIIB/IV non-small cell lung cancer. J Clin Oncol 2006; 24: 688-94.
    • (2006) J Clin Oncol , vol.24 , pp. 688-694
    • Yasuda, H.1    Yamaya, M.2    Nakayama, K.3
  • 99
    • 33845303951 scopus 로고    scopus 로고
    • Nitroglycerin treatment may increase response to docetaxel and carboplatin regimen via inhibitions of hypoxia-inducible factor-1 pathway and P-glycoprotein in patients with lung adenocarcinoma
    • Yasuda H, Nakayama K, Watanabe M et al. Nitroglycerin treatment may increase response to docetaxel and carboplatin regimen via inhibitions of hypoxia-inducible factor-1 pathway and P-glycoprotein in patients with lung adenocarcinoma. Clin Cancer Res 2006; 12: 6748-57.
    • (2006) Clin Cancer Res , vol.12 , pp. 6748-6757
    • Yasuda, H.1    Nakayama, K.2    Watanabe, M.3
  • 100
    • 84860741403 scopus 로고    scopus 로고
    • Therapeutic applications of nitric oxide for malignant tumor in animal models and human studies
    • Bonavida B, ed. New York: Springer Science
    • Yasuda H, Yanagihara K, Nakayama K et al. Therapeutic applications of nitric oxide for malignant tumor in animal models and human studies. In: Bonavida B, ed. Nitric Oxide and Cancer. New York: Springer Science, 2010; 419-441.
    • (2010) Nitric Oxide and Cancer , pp. 419-441
    • Yasuda, H.1    Yanagihara, K.2    Nakayama, K.3
  • 101
    • 0034267721 scopus 로고    scopus 로고
    • Changes in tumor oxygenation/perfusion induced by the NO donor, isosorbide dinitrate, in comparison with carbogen: monitoring by EPR and MRI
    • Jordan BF, Misson P, Demeure R, Baudelet C, Beghein N, Gallez B. Changes in tumor oxygenation/perfusion induced by the NO donor, isosorbide dinitrate, in comparison with carbogen: monitoring by EPR and MRI. Int J Radiat Oncol Biol Phys 2000; 48: 565-70.
    • (2000) Int J Radiat Oncol Biol Phys , vol.48 , pp. 565-570
    • Jordan, B.F.1    Misson, P.2    Demeure, R.3    Baudelet, C.4    Beghein, N.5    Gallez, B.6
  • 103
    • 0026520905 scopus 로고
    • T. Enhanced tumor localization of monoclonal antibody by treatment with kininase II inhibitor and angiotensin II
    • Noguchi A, Takahashi T, Yamaguchi T et al. T. Enhanced tumor localization of monoclonal antibody by treatment with kininase II inhibitor and angiotensin II. Jpn J Cancer Res 1992; 83: 240-3.
    • (1992) Jpn J Cancer Res , vol.83 , pp. 240-243
    • Noguchi, A.1    Takahashi, T.2    Yamaguchi, T.3
  • 104
    • 84871361336 scopus 로고    scopus 로고
    • Micelles of zinc protoporphyrin conjugated to N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer for imaging and light-induced antitumor effects in vivo
    • Nakamura H, Liao L, Hitaka Y et al. Micelles of zinc protoporphyrin conjugated to N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer for imaging and light-induced antitumor effects in vivo. J Control Release 2013; 165: 191-8.
    • (2013) J Control Release , vol.165 , pp. 191-198
    • Nakamura, H.1    Liao, L.2    Hitaka, Y.3
  • 105
    • 34547666680 scopus 로고    scopus 로고
    • Polymeric micelles of zinc protoporphyrin for tumor targeted delivery based on EPR effect and singlet oxygen generation
    • Iyer A, Greish K, Seki T et al. Polymeric micelles of zinc protoporphyrin for tumor targeted delivery based on EPR effect and singlet oxygen generation. J Drug Target 2007; 15: 496-506.
    • (2007) J Drug Target , vol.15 , pp. 496-506
    • Iyer, A.1    Greish, K.2    Seki, T.3
  • 106
    • 0036677602 scopus 로고    scopus 로고
    • Reinventing pharma: the theranostic revolution
    • Funkhouser J. Reinventing pharma: the theranostic revolution. Curr Drug Discov 2002; 2: 17-9.
    • (2002) Curr Drug Discov , vol.2 , pp. 17-19
    • Funkhouser, J.1
  • 107
    • 80054821668 scopus 로고    scopus 로고
    • Theranostics: combining imaging and therapy
    • Kelkar S, Reineke T. Theranostics: combining imaging and therapy. Bioconjug Chem 2011; 22: 1879-1903.
    • (2011) Bioconjug Chem , vol.22 , pp. 1879-1903
    • Kelkar, S.1    Reineke, T.2
  • 108
    • 33845625261 scopus 로고    scopus 로고
    • Development of a novel systemic gene delivery system for cancer therapy with a tumor-specific cleavable PEG-lipid
    • Hatakeyama H, Akita H, Kogure K, Harashima H. Development of a novel systemic gene delivery system for cancer therapy with a tumor-specific cleavable PEG-lipid. Gene Ther 2007; 14: 68-77.
    • (2007) Gene Ther , vol.14 , pp. 68-77
    • Hatakeyama, H.1    Akita, H.2    Kogure, K.3    Harashima, H.4
  • 109
    • 80054695837 scopus 로고    scopus 로고
    • Intracellular uptake and behavior of two types zinc protoporphyrin (ZnPP) micelles, SMA-ZnPP and PEG-ZnPP as anticancer agents; unique intracellular disintegration of SMA micelles
    • Nakamura H, Fang J, Gahininath B, Tsukigawa K, Maeda H. Intracellular uptake and behavior of two types zinc protoporphyrin (ZnPP) micelles, SMA-ZnPP and PEG-ZnPP as anticancer agents; unique intracellular disintegration of SMA micelles. J Control Release 2011; 155: 367-75.
    • (2011) J Control Release , vol.155 , pp. 367-375
    • Nakamura, H.1    Fang, J.2    Gahininath, B.3    Tsukigawa, K.4    Maeda, H.5
  • 110
    • 0023212748 scopus 로고
    • Binding to and internalization by cultured cells of neocarzinostatin and enhancement of its actions by conjugation with lipophilic styrene-maleic acid copolymer
    • Oda T, Maeda H. Binding to and internalization by cultured cells of neocarzinostatin and enhancement of its actions by conjugation with lipophilic styrene-maleic acid copolymer. Cancer Res 1987; 47: 3206-11.
    • (1987) Cancer Res , vol.47 , pp. 3206-3211
    • Oda, T.1    Maeda, H.2
  • 111
    • 0023552720 scopus 로고
    • Facilitated internalization of neocarzinostatin and its lipophilic polymer conjugate, SMANCS, into cytosol in acidic pH
    • Oda T, Sato F, Maeda H. Facilitated internalization of neocarzinostatin and its lipophilic polymer conjugate, SMANCS, into cytosol in acidic pH. J Nat Cancer Inst 1987; 9: 1205-11.
    • (1987) J Nat Cancer Inst , vol.9 , pp. 1205-1211
    • Oda, T.1    Sato, F.2    Maeda, H.3
  • 112
    • 0022586791 scopus 로고
    • Stimulation of macrophage by polyanions and its conjugated proteins and effect on cell membrane
    • Oda T, Morinaga T, Maeda H. Stimulation of macrophage by polyanions and its conjugated proteins and effect on cell membrane. Proc Soc Exp Biol Med 1986; 181: 9-17.
    • (1986) Proc Soc Exp Biol Med , vol.181 , pp. 9-17
    • Oda, T.1    Morinaga, T.2    Maeda, H.3
  • 113
    • 81855170441 scopus 로고    scopus 로고
    • Nanomedicine(s) under the microscope
    • Duncan R, Gaspar R. Nanomedicine(s) under the microscope. Mol Pharm 2011; 8: 2101-41.
    • (2011) Mol Pharm , vol.8 , pp. 2101-2141
    • Duncan, R.1    Gaspar, R.2
  • 114
    • 33847635618 scopus 로고    scopus 로고
    • Improvement of cancer-targeting therapy, using nanocarriers for intractable solid tumors by inhibition of TGF-β signaling
    • Kano M, Bae C, Iwata Y et al. Improvement of cancer-targeting therapy, using nanocarriers for intractable solid tumors by inhibition of TGF-β signaling. Proc Natl Acad Sci U S A 2007; 104: 3460-65.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 3460-3465
    • Kano, M.1    Bae, C.2    Iwata, Y.3
  • 115
    • 82755197640 scopus 로고    scopus 로고
    • Tumour necrosis factor-alpha increases extravasation of virus particles into tumour tissue by activating the Rho A/Rho kinase pathway
    • Seki T, Carroll F, Illingworth S et al. Tumour necrosis factor-alpha increases extravasation of virus particles into tumour tissue by activating the Rho A/Rho kinase pathway. J Control Release 2011; 156: 381-89.
    • (2011) J Control Release , vol.156 , pp. 381-389
    • Seki, T.1    Carroll, F.2    Illingworth, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.