A pan caspase inhibitor decreases caspase-1, IL-1α and IL-1β, and protects against necrosis of cisplatin-treated freshly isolated proximal tubules

Renal Failure

Volumn 37, Issue 1, 2015, Pages 144-150

  Lee, Dong Won ^a   Faubel, Sarah ^b   Edelstein, Charles L ^b  

^a Pusan National University Yangsan Hospital   (South Korea)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

Acute kidney injury; Caspase 1; Cisplatin; Inflammasomes; Kidney tubules proximal

Indexed keywords

CASPASE; CASPASE INHIBITOR; CISPLATIN; CRYOPYRIN; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; LACTATE DEHYDROGENASE; PROPIDIUM IODIDE; PEPTIDE CHLOROMETHYL KETONE; PROTECTIVE AGENT; QUINOLINE DERIVATIVE; QUINOLINE-VAL-ASP(OME)-CH2-OPH;

ANIMAL TISSUE; ARTICLE; CELL MEMBRANE; CENTRIFUGATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME RELEASE; IMMUNOFLUORESCENCE; KIDNEY NECROSIS; KIDNEY PROXIMAL TUBULE; MOUSE; NONHUMAN; RENAL PROTECTION; ANIMAL; C57BL MOUSE; CHEMICALLY INDUCED; DRUG EFFECTS; METABOLISM; NECROSIS; PATHOLOGY;

AMINO ACID CHLOROMETHYL KETONES; ANIMALS; CASPASE 1; CASPASE INHIBITORS; CISPLATIN; INTERLEUKIN-1ALPHA; INTERLEUKIN-1BETA; KIDNEY TUBULES, PROXIMAL; MICE; MICE, INBRED C57BL; NECROSIS; PROTECTIVE AGENTS; QUINOLINES;

EID: 84919455895     PISSN: 0886022X     EISSN: 15256049     Source Type: Journal    
DOI: 10.3109/0886022X.2014.970194     Document Type: Article

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