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Volumn 23, Issue 12, 2009, Pages 822-828

The role of iron in the pathophysiology and treatment of chronic hepatitis C

Author keywords

Hemochromatosis; Hepatitis C; Iron overload

Indexed keywords

ALPHA2A INTERFERON; ALPHA2B INTERFERON; HFE PROTEIN; INTERFERON; IRON; PEGINTERFERON ALPHA2A; RIBAVIRIN;

EID: 73349085875     PISSN: 08357900     EISSN: None     Source Type: Journal    
DOI: 10.1155/2009/290383     Document Type: Review
Times cited : (59)

References (61)
  • 1
    • 85036798850 scopus 로고    scopus 로고
    • Disease burden from hepatitis C in the US. (Version current at June 24, 2008).
    • Disease burden from hepatitis C in the US. (Version current at June 24, 2008).
  • 2
    • 85036785458 scopus 로고    scopus 로고
    • Hepatitis C. (version current at October 1, 2000).
    • Hepatitis C. (version current at October 1, 2000).
  • 3
    • 0032547938 scopus 로고    scopus 로고
    • Interferon alfa-2b alone or in combination with ribavirin as initial treatment for chronic hepatitis C
    • McHutchinson JG, Gordon SC, Schiff ER, et al. Interferon alfa-2b alone or in combination with ribavirin as initial treatment for chronic hepatitis C. N Engl J Med 1998;339:1485-92.
    • (1998) N Engl J Med , vol.339 , pp. 1485-1492
    • McHutchinson, J.G.1    Gordon, S.C.2    Schiff, E.R.3
  • 4
    • 34247547346 scopus 로고    scopus 로고
    • Iron, haemochromatosis and thalassaemia as risk factors for fibrosis in hepatitis C virus infection
    • Thursz M. Iron, haemochromatosis and thalassaemia as risk factors for fibrosis in hepatitis C virus infection. Gut 2007;56:613-4.
    • (2007) Gut , vol.56 , pp. 613-614
    • Thursz, M.1
  • 5
    • 44849129329 scopus 로고    scopus 로고
    • Comparison of hepatic oxidative DNA damage in patients with chronic hepatitis B and C
    • Fujita N, Sugimoto R, Ma N, et al. Comparison of hepatic oxidative DNA damage in patients with chronic hepatitis B and C. J Viral Hepatol 2008;15:498-507.
    • (2008) J Viral Hepatol , vol.15 , pp. 498-507
    • Fujita, N.1    Sugimoto, R.2    Ma, N.3
  • 6
    • 1642520853 scopus 로고    scopus 로고
    • Hepatic stellate cells in hepatitis C patients: Relationship with liver iron deposits and severity of liver disease
    • Martinelli AL, Ramalho LN, Zucoloto S. Hepatic stellate cells in hepatitis C patients: Relationship with liver iron deposits and severity of liver disease. J Gastroenterol Hepatol 2004;19:91-8.
    • (2004) J Gastroenterol Hepatol , vol.19 , pp. 91-98
    • Martinelli, A.L.1    Ramalho, L.N.2    Zucoloto, S.3
  • 7
    • 37349065804 scopus 로고    scopus 로고
    • Hepatitis C virus-induced reactive oxygen species raise hepatic iron level in mice by reducing hepcidin transcription
    • Nishina S, Hino K, Korenaga M, et al. Hepatitis C virus-induced reactive oxygen species raise hepatic iron level in mice by reducing hepcidin transcription. Gastroenterology 2008;134:226-38.
    • (2008) Gastroenterology , vol.134 , pp. 226-238
    • Nishina, S.1    Hino, K.2    Korenaga, M.3
  • 8
    • 37349099045 scopus 로고    scopus 로고
    • HCV, iron, and oxidative stress: The new choreography of hepcidin
    • Trinder D, Ayonrinde OT, Olynyk JK. HCV, iron, and oxidative stress: The new choreography of hepcidin. Gastroenterology 2008;134:348-51.
    • (2008) Gastroenterology , vol.134 , pp. 348-351
    • Trinder, D.1    Ayonrinde, O.T.2    Olynyk, J.K.3
  • 9
    • 33847609799 scopus 로고    scopus 로고
    • Hepcidin expression in the liver: Relatively low level in patients with chronic hepatitis C
    • Fujita N, Sugimoto R, Takeo M, et al. Hepcidin expression in the liver: Relatively low level in patients with chronic hepatitis C. Mol Med 2007;13:97-104.
    • (2007) Mol Med , vol.13 , pp. 97-104
    • Fujita, N.1    Sugimoto, R.2    Takeo, M.3
  • 11
    • 34948817771 scopus 로고    scopus 로고
    • Hepatic iron accumulation is associated with disease progression and resistance to interferon/ ribavirin combination therapy in chronic hepatitis C
    • Fujita N, Sugimotot R, Urawa N, et al. Hepatic iron accumulation is associated with disease progression and resistance to interferon/ ribavirin combination therapy in chronic hepatitis C. J Gastroenterol Hepatol 2007;22:1886-93.
    • (2007) J Gastroenterol Hepatol , vol.22 , pp. 1886-1893
    • Fujita, N.1    Sugimotot, R.2    Urawa, N.3
  • 13
    • 0344129013 scopus 로고    scopus 로고
    • Liver iron accumulation in patients with chronic active hepatitis C: Prevalence and role of hemochromatosis gene mutations and relationship with hepatic histological lesions
    • Hezode C, Cazeneuve C, Coue O, et al. Liver iron accumulation in patients with chronic active hepatitis C: Prevalence and role of hemochromatosis gene mutations and relationship with hepatic histological lesions. J Hepatol 1999;31:979-84.
    • (1999) J Hepatol , vol.31 , pp. 979-984
    • Hezode, C.1    Cazeneuve, C.2    Coue, O.3
  • 14
    • 0028915570 scopus 로고
    • Hepatic iron concentration as a predictor of response to interferon-alfa therapy in chronic hepatitis C
    • Olynyk JK, Reddy KR, Di Bisceglie AM, et al. Hepatic iron concentration as a predictor of response to interferon-alfa therapy in chronic hepatitis C. Gastroenterology 1995;108:1104-9.
    • (1995) Gastroenterology , vol.108 , pp. 1104-1109
    • Olynyk, J.K.1    Reddy, K.R.2    Di Bisceglie, A.M.3
  • 15
    • 33750684267 scopus 로고    scopus 로고
    • Roles of iron and HFE mutations on severity and response to therapy during retreatment of advanced chronic hepatitis C
    • Bonkovsky HL, Naishadham D, Lambreacht RW, et al. Roles of iron and HFE mutations on severity and response to therapy during retreatment of advanced chronic hepatitis C. Gastroenterology 2006;131:1440-51.
    • (2006) Gastroenterology , vol.131 , pp. 1440-1451
    • Bonkovsky, H.L.1    Naishadham, D.2    Lambreacht, R.W.3
  • 17
    • 0031801787 scopus 로고    scopus 로고
    • Heterozygosity for hereditary hemochromatosis is associated with more fibrosis in chronic hepatitis C
    • Smith BC, Grove J, Guzail MA, et al. Heterozygosity for hereditary hemochromatosis is associated with more fibrosis in chronic hepatitis C. Hepatology 1998;27:1695-9.
    • (1998) Hepatology , vol.27 , pp. 1695-1699
    • Smith, B.C.1    Grove, J.2    Guzail, M.A.3
  • 18
    • 0031706520 scopus 로고    scopus 로고
    • Hepatic iron overload in patients with chronic viral hepatitis: Role of HFE gene mutations
    • Piperno A, Vergani A, Malosio D, et al. Hepatic iron overload in patients with chronic viral hepatitis: Role of HFE gene mutations. Hepatology 1998;28:1105-9.
    • (1998) Hepatology , vol.28 , pp. 1105-1109
    • Piperno, A.1    Vergani, A.2    Malosio, D.3
  • 19
    • 0036893631 scopus 로고    scopus 로고
    • Iron and HFE or TfR1 mutations as comorbid factors for development and progression of chronic hepatitis C
    • Bonkovsky HL, Troy N, McNeal K, et al. Iron and HFE or TfR1 mutations as comorbid factors for development and progression of chronic hepatitis C. J Hepatol 2002;37:848-54.
    • (2002) J Hepatol , vol.37 , pp. 848-854
    • Bonkovsky, H.L.1    Troy, N.2    McNeal, K.3
  • 20
    • 0032947967 scopus 로고    scopus 로고
    • The relation of iron status and hemochromatosis gene mutations in patients with chronic hepatitis C
    • Kazemi-Shirazi L, Datz C, Maier-Dobersberger T, et al. The relation of iron status and hemochromatosis gene mutations in patients with chronic hepatitis C. Gastroenterology 1999;116:127-34.
    • (1999) Gastroenterology , vol.116 , pp. 127-134
    • Kazemi-Shirazi, L.1    Datz, C.2    Maier-Dobersberger, T.3
  • 21
    • 0037336495 scopus 로고    scopus 로고
    • HFE mutations and chronic hepatitis C: H63D and C282Y heterozygosity are independent risk factors for liver fibrosis and cirrhosis
    • Erhardt A, Maschner-Olberg A, Mellenthin C, et al. HFE mutations and chronic hepatitis C: H63D and C282Y heterozygosity are independent risk factors for liver fibrosis and cirrhosis. J Hepatol 2003;38:335-42.
    • (2003) J Hepatol , vol.38 , pp. 335-342
    • Erhardt, A.1    Maschner-Olberg, A.2    Mellenthin, C.3
  • 22
    • 0346843108 scopus 로고    scopus 로고
    • Hemochromatosis and transferrin receptor gene polymorphisms in chronic hepatitis C: Impact on iron status, liver injury, and HCV genotype
    • Gehrke S, Stremmel W, Mathes I, Riedel H, Bents K, Kallinowski B. Hemochromatosis and transferrin receptor gene polymorphisms in chronic hepatitis C: Impact on iron status, liver injury, and HCV genotype. J Mol Med 2003;81:780-7.
    • (2003) J Mol Med , vol.81 , pp. 780-787
    • Gehrke, S.1    Stremmel, W.2    Mathes, I.3    Riedel, H.4    Bents, K.5    Kallinowski, B.6
  • 23
    • 4444377059 scopus 로고    scopus 로고
    • Geier A, Reugels M, Weiskirchen R, et al. Common heterozygous hemochromatosis gene mutations are risk factors for inflammation and fibrosis in chronic hepatitis C. Liv Int 2004;24:285-94.
    • Geier A, Reugels M, Weiskirchen R, et al. Common heterozygous hemochromatosis gene mutations are risk factors for inflammation and fibrosis in chronic hepatitis C. Liv Int 2004;24:285-94.
  • 24
    • 0036155984 scopus 로고    scopus 로고
    • The role of iron and haemochromatosis gene mutations in the progression of liver disease in chronic hepatitis C
    • Thorburn D, Curry G, Spooner R, et al. The role of iron and haemochromatosis gene mutations in the progression of liver disease in chronic hepatitis C. Gut 2002;50:248-52.
    • (2002) Gut , vol.50 , pp. 248-252
    • Thorburn, D.1    Curry, G.2    Spooner, R.3
  • 25
    • 0033731320 scopus 로고    scopus 로고
    • C282Y mutation and hepatic iron status in hepatitis C and cryptogenic cirrhosis
    • Lal P, Fernandes H, Koneru B, Albanese E, Hameed M. C282Y mutation and hepatic iron status in hepatitis C and cryptogenic cirrhosis. Arch Pathol Lab Med 2000;124:1632-5.
    • (2000) Arch Pathol Lab Med , vol.124 , pp. 1632-1635
    • Lal, P.1    Fernandes, H.2    Koneru, B.3    Albanese, E.4    Hameed, M.5
  • 26
    • 0034056296 scopus 로고    scopus 로고
    • Iron deposition and progression of disease in chronic hepatitis C
    • Pirisi M, Scott CA, Avellini C, et al. Iron deposition and progression of disease in chronic hepatitis C. Am J Clin Pathol 2000;113:546-54.
    • (2000) Am J Clin Pathol , vol.113 , pp. 546-554
    • Pirisi, M.1    Scott, C.A.2    Avellini, C.3
  • 27
    • 0033991918 scopus 로고    scopus 로고
    • Hemochromatosis gene mutations in chronic hepatitis C patients with and without liver siderosis
    • Negro F, Samii K, Rubbia-Brandt L, et al. Hemochromatosis gene mutations in chronic hepatitis C patients with and without liver siderosis. J Med Virol 2000;60:21-7.
    • (2000) J Med Virol , vol.60 , pp. 21-27
    • Negro, F.1    Samii, K.2    Rubbia-Brandt, L.3
  • 28
    • 0034529541 scopus 로고    scopus 로고
    • Heterozygosity for the hemochromatosis gene in liver diseases -prevalence and effects on liver histology
    • Hohler T, Leininger S, Kohler HH, Schirmacher P, Galle PR. Heterozygosity for the hemochromatosis gene in liver diseases -prevalence and effects on liver histology. Liver 2000;20:482-6.
    • (2000) Liver , vol.20 , pp. 482-486
    • Hohler, T.1    Leininger, S.2    Kohler, H.H.3    Schirmacher, P.4    Galle, P.R.5
  • 29
    • 0037285572 scopus 로고    scopus 로고
    • Mutations of the HFE gene in patients with hepatocellular carcinoma
    • Cauza E, Peck-Radosavljevic M, Ulrich-Pur H, et al. Mutations of the HFE gene in patients with hepatocellular carcinoma. Am J Gastroenterol 2003;98:442-7.
    • (2003) Am J Gastroenterol , vol.98 , pp. 442-447
    • Cauza, E.1    Peck-Radosavljevic, M.2    Ulrich-Pur, H.3
  • 31
    • 0036123930 scopus 로고    scopus 로고
    • HFE gene mutations in alcoholic and virus-related cirrhotic patients with hepatocellular carcinoma
    • Lauret E, Rodriguez M, Gonzalez S, et al. HFE gene mutations in alcoholic and virus-related cirrhotic patients with hepatocellular carcinoma. Am J Gastroenterol 2002;97:1016-21.
    • (2002) Am J Gastroenterol , vol.97 , pp. 1016-1021
    • Lauret, E.1    Rodriguez, M.2    Gonzalez, S.3
  • 32
    • 0037961144 scopus 로고    scopus 로고
    • Lack of association between HFE gene mutations and hepatocellular carcinoma in patients with cirrhosis
    • Boige V, Castera L, de Roux N, et al. Lack of association between HFE gene mutations and hepatocellular carcinoma in patients with cirrhosis. Gut 2003;52:1178-81.
    • (2003) Gut , vol.52 , pp. 1178-1181
    • Boige, V.1    Castera, L.2    de Roux, N.3
  • 33
    • 7044222320 scopus 로고    scopus 로고
    • Iron, hemochromatosis, and hepatocellular carcinoma
    • Kowdley KV. Iron, hemochromatosis, and hepatocellular carcinoma. Gastroenterology 2004;127:S79-S86.
    • (2004) Gastroenterology , vol.127
    • Kowdley, K.V.1
  • 35
    • 0030037708 scopus 로고    scopus 로고
    • Relationship between hepatic iron deposits and response to interferon in chronic hepatitis C
    • Ikura Y, Morimoto H, Johmura H, Fukui M, Sakurai M. Relationship between hepatic iron deposits and response to interferon in chronic hepatitis C. Am J Gastroenterol 1996;91:1367-73.
    • (1996) Am J Gastroenterol , vol.91 , pp. 1367-1373
    • Ikura, Y.1    Morimoto, H.2    Johmura, H.3    Fukui, M.4    Sakurai, M.5
  • 36
    • 17544383347 scopus 로고    scopus 로고
    • Iron reduction before and during interferon therapy of chronic hepatitis C: Results of a multicenter, randomized, controlled trial
    • Fontana RJ, Israel J, LeClair P, et al. Iron reduction before and during interferon therapy of chronic hepatitis C: Results of a multicenter, randomized, controlled trial. Hepatology 2000;31:730-6.
    • (2000) Hepatology , vol.31 , pp. 730-736
    • Fontana, R.J.1    Israel, J.2    LeClair, P.3
  • 37
    • 19244382256 scopus 로고    scopus 로고
    • Iron reduction and sustained response to interferon-alpha therapy in patients with chronic hepatitis C: Results of an Italian multicenter randomized study
    • Fargion S, Fracanzani AL, Rossini A, et al. Iron reduction and sustained response to interferon-alpha therapy in patients with chronic hepatitis C: Results of an Italian multicenter randomized study. Am J Gastroenterol 2002;97:1204-10.
    • (2002) Am J Gastroenterol , vol.97 , pp. 1204-1210
    • Fargion, S.1    Fracanzani, A.L.2    Rossini, A.3
  • 38
    • 0032032484 scopus 로고    scopus 로고
    • A pilot randomized, controlled trial of the effect of iron depletion on long-term response to alphainterferon in patients with chronic hepatitis C
    • Fong TL, Han SH, Tsai NC, et al. A pilot randomized, controlled trial of the effect of iron depletion on long-term response to alphainterferon in patients with chronic hepatitis C. J Hepatol 1998;28:369-74.
    • (1998) J Hepatol , vol.28 , pp. 369-374
    • Fong, T.L.1    Han, S.H.2    Tsai, N.C.3
  • 39
    • 0141651602 scopus 로고    scopus 로고
    • Iron depletion and response to interferon in chronic hepatitis C
    • Carlo C, Daniela P, Giancarlo C. Iron depletion and response to interferon in chronic hepatitis C. Hepatol Gastroenterol 2003;50:1467-71.
    • (2003) Hepatol Gastroenterol , vol.50 , pp. 1467-1471
    • Carlo, C.1    Daniela, P.2    Giancarlo, C.3
  • 40
    • 9544221635 scopus 로고    scopus 로고
    • Iron stores, response to alpha-interferon therapy, and effects of iron depletion in chronic hepatitis C
    • Piperno A, Sampietro M, D'Alba R, et al. Iron stores, response to alpha-interferon therapy, and effects of iron depletion in chronic hepatitis C. Liver 1996;16:248-54.
    • (1996) Liver , vol.16 , pp. 248-254
    • Piperno, A.1    Sampietro, M.2    D'Alba, R.3
  • 41
    • 39849093715 scopus 로고    scopus 로고
    • Phlebotomy improves therapeutic response to interferon in patients with chronic hepatitis C: A meta-analysis of six prospective randomized controlled trials
    • Desai TK, Jamil LH, Balasubramaniam M, Koff R, Bonkovsky HL. Phlebotomy improves therapeutic response to interferon in patients with chronic hepatitis C: A meta-analysis of six prospective randomized controlled trials. Dig Dis Sci 2008;53:815-22.
    • (2008) Dig Dis Sci , vol.53 , pp. 815-822
    • Desai, T.K.1    Jamil, L.H.2    Balasubramaniam, M.3    Koff, R.4    Bonkovsky, H.L.5
  • 42
    • 0034235427 scopus 로고    scopus 로고
    • Iron reduction as an adjuvant to interferon therapy in patients with chronic hepatitis C who have previously not responded to interferon: A multicenter, prospective, randomized, controlled trial
    • Di Bisceglie AM, Bonkovsky HL, Chopra S, et al. Iron reduction as an adjuvant to interferon therapy in patients with chronic hepatitis C who have previously not responded to interferon: A multicenter, prospective, randomized, controlled trial. Hepatology 2000;32:135-8.
    • (2000) Hepatology , vol.32 , pp. 135-138
    • Di Bisceglie, A.M.1    Bonkovsky, H.L.2    Chopra, S.3
  • 43
    • 0032975993 scopus 로고    scopus 로고
    • A pilot study of iron depletion as adjuvant therapy in chronic hepatitis C patients not responding to interferon
    • Guyader D, Boucher E, Andre P, et al. A pilot study of iron depletion as adjuvant therapy in chronic hepatitis C patients not responding to interferon. Am J Gastroenterol 1999;94:1696-8.
    • (1999) Am J Gastroenterol , vol.94 , pp. 1696-1698
    • Guyader, D.1    Boucher, E.2    Andre, P.3
  • 44
    • 34247638591 scopus 로고    scopus 로고
    • Effect of iron depletion on serum markers of fibrogenesis, oxidative stress and serum liver enzymes in chronic hepatitis C: Results of a pilot study
    • Alexander J, Tung BY, Croghan A, Kowdley KV. Effect of iron depletion on serum markers of fibrogenesis, oxidative stress and serum liver enzymes in chronic hepatitis C: Results of a pilot study. Liver Int 2007;27:268-73.
    • (2007) Liver Int , vol.27 , pp. 268-273
    • Alexander, J.1    Tung, B.Y.2    Croghan, A.3    Kowdley, K.V.4
  • 45
    • 0030774786 scopus 로고    scopus 로고
    • Effect of iron depletion on long-term response to interferon-alpha in patients with chronic hepatitis C who previously did not respond to interferon therapy
    • Tsai N, Zuckerman E, Han SH, Goad K, Redeker AG, Fong TL. Effect of iron depletion on long-term response to interferon-alpha in patients with chronic hepatitis C who previously did not respond to interferon therapy. Am J Gastroenterol 1997;92:1831-4.
    • (1997) Am J Gastroenterol , vol.92 , pp. 1831-1834
    • Tsai, N.1    Zuckerman, E.2    Han, S.H.3    Goad, K.4    Redeker, A.G.5    Fong, T.L.6
  • 46
    • 0030471382 scopus 로고    scopus 로고
    • Retreatment of hepatitis C interferon non-responders with larger doses of interferon with and without phlebotomy
    • Van Thiel DH, Friedlander L, Molloy PJ, et al. Retreatment of hepatitis C interferon non-responders with larger doses of interferon with and without phlebotomy. Hepatogastroenterology 1996;43:1557-61.
    • (1996) Hepatogastroenterology , vol.43 , pp. 1557-1561
    • Van Thiel, D.H.1    Friedlander, L.2    Molloy, P.J.3
  • 47
    • 0036087591 scopus 로고    scopus 로고
    • Coelho-Borges S, Cheinquer H, Cheinquer N, Krug L, Ashton-Prollo P. HFE gene mutations prevent sustained virological response to interferon plus ribavirin in chronic hepatitis C patients with serum markers of iron overload. AJG 2002;97:1570-2.
    • Coelho-Borges S, Cheinquer H, Cheinquer N, Krug L, Ashton-Prollo P. HFE gene mutations prevent sustained virological response to interferon plus ribavirin in chronic hepatitis C patients with serum markers of iron overload. AJG 2002;97:1570-2.
  • 48
    • 3242887231 scopus 로고    scopus 로고
    • A significant reduction in serum alanine aminotransferase levels after 3-month iron reduction therapy for chronic hepatitis C: A multicenter, prospective, randomized, controlled trial in Japan
    • Yano M, Hayashi H, Yoshioka K, et al. A significant reduction in serum alanine aminotransferase levels after 3-month iron reduction therapy for chronic hepatitis C: A multicenter, prospective, randomized, controlled trial in Japan. J Gastroenterol 2004;39:570-4.
    • (2004) J Gastroenterol , vol.39 , pp. 570-574
    • Yano, M.1    Hayashi, H.2    Yoshioka, K.3
  • 49
    • 0036140561 scopus 로고    scopus 로고
    • Long term effects of phlebotomy on biochemical and histological parameters of chronic hepatitis C
    • Yano M, Hayashi H, Wakusawa S, et al. Long term effects of phlebotomy on biochemical and histological parameters of chronic hepatitis C. Am J Gastroenterol 2002;97:133-7.
    • (2002) Am J Gastroenterol , vol.97 , pp. 133-137
    • Yano, M.1    Hayashi, H.2    Wakusawa, S.3
  • 50
    • 27244435206 scopus 로고    scopus 로고
    • Determinants of serum ALT normalization after phlebotomy in patients with chronic hepatitis C infection
    • Kawamura Y, Akuta N, Sezaki H, et al. Determinants of serum ALT normalization after phlebotomy in patients with chronic hepatitis C infection. J Gastroenterol 2005;40:901-6.
    • (2005) J Gastroenterol , vol.40 , pp. 901-906
    • Kawamura, Y.1    Akuta, N.2    Sezaki, H.3
  • 51
    • 2442658823 scopus 로고    scopus 로고
    • Hepatic iron concentration does not predict response to standard and pegylated-IFN/ribavirin therapy in patients with chronic hepatitis C
    • Hofer H, Osterreicher C, Jessner W, et al. Hepatic iron concentration does not predict response to standard and pegylated-IFN/ribavirin therapy in patients with chronic hepatitis C. J Hepatol 2004;40:1018-22.
    • (2004) J Hepatol , vol.40 , pp. 1018-1022
    • Hofer, H.1    Osterreicher, C.2    Jessner, W.3
  • 52
    • 13944256260 scopus 로고    scopus 로고
    • Relationships between hepatic iron content and virologic response in chronic hepatitis C patients treated with interferon and ribavirin
    • Rulyak SJ, Eng SC, Patel K, McHutchinson JG, Gordon SC, Kowdley K. Relationships between hepatic iron content and virologic response in chronic hepatitis C patients treated with interferon and ribavirin. Am J Gastroenterol 2005;100:332-7.
    • (2005) Am J Gastroenterol , vol.100 , pp. 332-337
    • Rulyak, S.J.1    Eng, S.C.2    Patel, K.3    McHutchinson, J.G.4    Gordon, S.C.5    Kowdley, K.6
  • 53
    • 0036267134 scopus 로고    scopus 로고
    • Hepatic iron concentration does not influence response to therapy with interferon plus ribavirin in chronic HCV infection
    • Pianko S, McHutchison JG, Gordon SC, et al. Hepatic iron concentration does not influence response to therapy with interferon plus ribavirin in chronic HCV infection. J Interferon Cytokine Res 2002;22:483-9.
    • (2002) J Interferon Cytokine Res , vol.22 , pp. 483-489
    • Pianko, S.1    McHutchison, J.G.2    Gordon, S.C.3
  • 54
    • 33744512454 scopus 로고    scopus 로고
    • Hepatic iron overload induces hepatocellular carcinoma in transgenic mice expressing the hepatitis C virus polyprotein
    • Takakazu F, Keisuke H, Michiari O, et al. Hepatic iron overload induces hepatocellular carcinoma in transgenic mice expressing the hepatitis C virus polyprotein. Gastroenterology 2006;130:2087-98.
    • (2006) Gastroenterology , vol.130 , pp. 2087-2098
    • Takakazu, F.1    Keisuke, H.2    Michiari, O.3
  • 55
    • 0034027392 scopus 로고    scopus 로고
    • Liver iron excess in patients with hepatocellular carcinoma developed on viral C cirrhosis
    • Chapoutot C, Esslimani M, Joomaye Z, et al. Liver iron excess in patients with hepatocellular carcinoma developed on viral C cirrhosis. Gut 2000;46:711-4.
    • (2000) Gut , vol.46 , pp. 711-714
    • Chapoutot, C.1    Esslimani, M.2    Joomaye, Z.3
  • 56
    • 36348935617 scopus 로고    scopus 로고
    • Prevalence of hepatic iron overload and association with hepatocellular cancer in end-stage liver disease: Results from the National Hemochromatosis Transplant Registry
    • Ko C, Siddaiah N, Berger J, et al. Prevalence of hepatic iron overload and association with hepatocellular cancer in end-stage liver disease: Results from the National Hemochromatosis Transplant Registry. Liv Int 2007;27:1394-1401.
    • (2007) Liv Int , vol.27 , pp. 1394-1401
    • Ko, C.1    Siddaiah, N.2    Berger, J.3
  • 57
    • 35448952080 scopus 로고    scopus 로고
    • Long-term phlebotomy with low-iron diet therapy lowers risk of development of hepatocellular carcinoma from chronic hepatitis C
    • Kato J, Miyanishi K, Kobune M, et al. Long-term phlebotomy with low-iron diet therapy lowers risk of development of hepatocellular carcinoma from chronic hepatitis C. J Gastroenterol 2007;42:830-6.
    • (2007) J Gastroenterol , vol.42 , pp. 830-836
    • Kato, J.1    Miyanishi, K.2    Kobune, M.3
  • 58
    • 0035893552 scopus 로고    scopus 로고
    • Normalization of elevated hepatic 8-hydroxy-2-deoxyguanosine levels in chronic hepatitis C patients by phlebotomy and low iron diet
    • Kato J, Kobune M, Nakamura T, et al. Normalization of elevated hepatic 8-hydroxy-2-deoxyguanosine levels in chronic hepatitis C patients by phlebotomy and low iron diet. Cancer Res 2001;61:8697-702.
    • (2001) Cancer Res , vol.61 , pp. 8697-8702
    • Kato, J.1    Kobune, M.2    Nakamura, T.3
  • 59
    • 38949216684 scopus 로고    scopus 로고
    • Tanaka H, Fujita N, Sugimoto R, et al. Hepatic oxidative DNA damage is associated with increased risk for hepatocellular carcinoma in chronic hepatitis C. BJC 2008;98:580-6.
    • Tanaka H, Fujita N, Sugimoto R, et al. Hepatic oxidative DNA damage is associated with increased risk for hepatocellular carcinoma in chronic hepatitis C. BJC 2008;98:580-6.
  • 60
    • 0034006343 scopus 로고    scopus 로고
    • Beneficial influence of an indigenous low-iron diet on serum indicators of iron status in patients with chronic liver disease
    • Tandon N, Thaker V, Kumkar R, Guptan C, Sarin SK. Beneficial influence of an indigenous low-iron diet on serum indicators of iron status in patients with chronic liver disease. British J Nutr 2000;83:235-9.
    • (2000) British J Nutr , vol.83 , pp. 235-239
    • Tandon, N.1    Thaker, V.2    Kumkar, R.3    Guptan, C.4    Sarin, S.K.5
  • 61
    • 34249825477 scopus 로고    scopus 로고
    • Effects of dietary iron reduction versus phlebotomy in patients with chronic hepatitis C: Results from a randomized, controlled trial on 40 Japanese patients
    • Sumida Y, Kanemasa K, Fukumoto K, Yoshida N, Sakai K. Effects of dietary iron reduction versus phlebotomy in patients with chronic hepatitis C: Results from a randomized, controlled trial on 40 Japanese patients. Intern Med 2007;46:637-42.
    • (2007) Intern Med , vol.46 , pp. 637-642
    • Sumida, Y.1    Kanemasa, K.2    Fukumoto, K.3    Yoshida, N.4    Sakai, K.5


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