Positive allosteric modulation of the GHB high-affinity binding site by the GABAA receptor modulator monastrol and the flavonoid catechin

European Journal of Pharmacology

Volumn 740, Issue , 2014, Pages 570-577

  Eghorn, Laura F ^a   Hoestgaard Jensen, Kirsten ^a   Kongstad, Kenneth T ^a   Bay, Tina ^a   Higgins, David ^b   Frølund, Bente ^a   Wellendorph, Petrine ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

Dihydropyrimidinone; Flavonoid; GHB receptor; NCS 382; Probe dependence; Hydroxybutyricacid

Indexed keywords

(6,7,8,9 TETRAHYDRO 5 HYDROXY 5H BENZOCYCLOHEPT 6 YLIDENE)ACETIC ACID H 3; 3 HYDROXYCYCLOPENT 1 ENECARBOXYLIC ACID H 3; 4 HYDROXY 4 [4 (2 IODOBENZYLOXY)PHENYL]BUTYRIC ACID I 125; 4 HYDROXYBUTYRIC ACID; CATECHIN; MONASTROL; RADIOPHARMACEUTICAL AGENT; RECOMBINANT ALPHA4BETA3DELTA RECEPTOR; RECOMBINANT PROTEIN; TAXIFOLIN; UNCLASSIFIED DRUG; 4 AMINOBUTYRIC ACID A RECEPTOR; 4-HYDROXYBUTYRIC ACID; FUSED ALICYCLIC AROMATIC COMPOUND; HYDROXYBUTYRIC ACID; NCS 382; PYRIMIDINE DERIVATIVE; THIOKETONE;

ALLOSTERISM; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; CONFORMATION; CONTROLLED STUDY; DISSOCIATION; DRUG PROTEIN BINDING; DRUG STRUCTURE; ELECTROPHYSIOLOGY; LIGAND BINDING; MALE; MOLECULAR PROBE; NONHUMAN; OOCYTE; RADIOASSAY; RAT; XENOPUS LAEVIS; ANIMAL; FEMALE; GENETICS; METABOLISM; PHYSIOLOGY;

ANIMALS; BENZOCYCLOHEPTENES; BINDING SITES; CATECHIN; FEMALE; HYDROXYBUTYRATES; OOCYTES; PYRIMIDINES; RECEPTORS, GABA-A; THIONES; XENOPUS LAEVIS;

EID: 84919425534     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2014.06.028     Document Type: Article

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