Design, synthesis, and in vitro pharmacology of new radiolabeled γ-hydroxybutyric acid analogues including photolabile analogues with irreversible binding to the high-affinity γ-hydroxybutyric acid binding sites

Journal of Medicinal Chemistry

Volumn 53, Issue 17, 2010, Pages 6506-6510

  Sabbatini, Paola ^a   Wellendorph, Petrine ^a   Høg, Signe ^a   Pedersen, Martin H F ^b   Bräuner Osborne, Hans ^a   Martiny, Lars ^b   Frølund, Bente ^a   Clausen, Rasmus P ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXY 4 [4 (2 IODOBENZYLOXY)PHENYL]BUTANOATE; 4 HYDROXYBUTYRIC ACID; IODINE 125; LITHIUM 4 [4 (2 AZIDO 5 IODOBENZYLOXY)PHENYL] 4 HYDROXYBUTANOATE; LITHIUM 4 [4 (4 AZIDO 5 IODOBENZYLOXY)PHENYL] 4 HYDROXYBUTANOATE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; PHOTOAFFINITY LABELING; RAT;

ANIMALS; AZIDES; BINDING SITES; BINDING, COMPETITIVE; CEREBRAL CORTEX; DRUG DESIGN; HYDROXYBUTYRATES; IODINE RADIOISOTOPES; LIGANDS; LIGHT; PHOTOAFFINITY LABELS; PROTEIN BINDING; RADIOLIGAND ASSAY; RATS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77956324294     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm1006325     Document Type: Article

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