Intraperitoneal and subcutaneous injections of the TLR9 agonist ODN 1668 in rats: Brain inflammatory responses are related to peripheral IL-6 rather than interferons

Journal of Neuroimmunology

Volumn 277, Issue 1-2, 2014, Pages 105-117

  Damm, J ^a   Wiegand, F ^a   Harden, L M ^a,b   Wenisch, S ^a   Gerstberger, R ^a   Rummel, C ^a   Roth, J ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

^b UNIVERSITY OF THE WITWATERSRAND   (South Africa)

Author keywords

Cytokines; Fever; Immune to brain signaling; Inflammatory transcription factors; Interferons; Toll like receptors

Indexed keywords

INTERFERON; INTERLEUKIN 1BETA; INTERLEUKIN 6; ODN 1668; PROSTAGLANDIN E2; STAT3 PROTEIN; TOLL LIKE RECEPTOR 9; TOLL LIKE RECEPTOR AGONIST; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; OLIGODEOXYRIBONUCLEOTIDE; TLR9 PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANOREXIA; ARTICLE; BRAIN TISSUE; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG MEGADOSE; DRUG RESPONSE; ENCEPHALITIS; ENDOTHELIUM CELL; FEVER; LOW DRUG DOSE; MALE; NONHUMAN; PROSTAGLANDIN SYNTHESIS; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN INDUCTION; RAT; RECEPTOR UPREGULATION; AGONISTS; ANIMAL; CHEMICALLY INDUCED; CHEMISTRY; DISEASE MODEL; DOSE RESPONSE; DRINKING; DRUG ADMINISTRATION ROUTE; DRUG EFFECTS; EATING; GENE EXPRESSION REGULATION; GENETICS; INTRAPERITONEAL DRUG ADMINISTRATION; METABOLISM; MOTOR ACTIVITY; SUBCUTANEOUS DRUG ADMINISTRATION; TIME; TOXICITY; WISTAR RAT;

ANIMALS; DINOPROSTONE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRINKING; DRUG ADMINISTRATION ROUTES; EATING; ENCEPHALITIS; GENE EXPRESSION REGULATION; INJECTIONS, INTRAPERITONEAL; INJECTIONS, SUBCUTANEOUS; INTERFERONS; INTERLEUKIN-6; MALE; MOTOR ACTIVITY; OLIGODEOXYRIBONUCLEOTIDES; RATS; RATS, WISTAR; TIME FACTORS; TOLL-LIKE RECEPTOR 9;

EID: 84919333843     PISSN: 01655728     EISSN: 18728421     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2014.10.007     Document Type: Article

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