Peripheral and central cyclooxygenase (COX) products may contribute to the manifestation of brain-controlled sickness responses during localized inflammation induced by macrophage-activating lipopeptide-2 (MALP-2)

Neuroscience Letters

Volumn 479, Issue 2, 2010, Pages 107-111

  Knorr, Carolin ^a   Marks, Doreen ^a   Gerstberger, Rüdiger ^a   Mühlradt, Peter F ^b   Roth, Joachim ^a   Rummel, Christoph ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

^b Wound Healing Research Group   (Germany)

Author keywords

Fever; Immune to brain communication; Prostaglandins; Transcription factors

Indexed keywords

CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MACROPHAGE ACTIVATING LIPOPEPTIDE 2; MELOXICAM; PROSTAGLANDIN E2; STAT3 PROTEIN; LIPOPEPTIDE; MACROPHAGE STIMULATORY LIPOPEPTIDE 2; STAT3 PROTEIN, RAT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY TEMPERATURE; BRAIN FUNCTION; BRAIN TISSUE; CELL NUCLEUS; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; FEVER; FLUID INTAKE; FOOD INTAKE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INFLAMMATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; ANIMAL; BIOSYNTHESIS; BRAIN; DRINKING; EATING; ENZYME INDUCTION; IMMUNOLOGY; INTRAPERITONEAL DRUG ADMINISTRATION; METABOLISM; MOTOR ACTIVITY; PATHOPHYSIOLOGY; PHYSIOLOGY; SUBCUTANEOUS DRUG ADMINISTRATION; WISTAR RAT;

ANIMALS; BRAIN; CYCLOOXYGENASE 2; DINOPROSTONE; DRINKING; EATING; ENZYME INDUCTION; FEVER; INFLAMMATION; INJECTIONS, INTRAPERITONEAL; INJECTIONS, SUBCUTANEOUS; LIPOPEPTIDES; MALE; MOTOR ACTIVITY; NF-KAPPA B; RATS; RATS, WISTAR; STAT3 TRANSCRIPTION FACTOR;

EID: 77953916766     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2010.05.036     Document Type: Article

References (21)

1. Besedovsky H.O., Del Rey A. Immune-neuro-endocrine interactions: facts and hypotheses. Endocr. Rev. 1996, 17:64-102.
2. Blatteis C.M. Endotoxic fever: new concepts of its regulation suggest new approaches to its management. Pharmacol. Ther. 2006, 111:194-223.
3. Dantzer R., O'Connor J.C., Freund G.G., Johnson R.W., Kelley K.W. From inflammation to sickness and depression: when the immune system subjugates the brain. Nat. Rev. Neurosci. 2008, 9:46-56.
4. Deiters U., Barsig J., Tawil B., Mühlradt P.F. The macrophage-activating lipopeptide-2 accelerates wound healing in diabetic mice. Exp. Dermatol. 2004, 13:731-739.
5. Galanos C., Gumenschneider M., Mühlradt P.F., Jirillo E., Freudenberg M.A. MALP-2, a Mycoplasma lipopeptide with classical endotoxic properties: end of an era of LPS monopoly?. J. Endotoxin Res. 2001, 6:471-476.
6. Harré E.M., Roth J., Pehl U., Kueth M., Gerstberger R., Hübschle T. Selected contribution: role of IL-6 in LPS-induced nuclear translocation in sensory circumventricular organs during fever in rats. J. Appl. Physiol. 2002, 92:2657-2666.
7. Hübschle T., Harré E.M., Mayerhof W., Pehl U., Roth J., Gerstberger R. The central pyrogenic action of interleukin-6 is related to nuclear translocation of STAT3 in the anteroventral preoptic area of the rat brain. J. Therm. Biol. 2001, 26:299-305.
8. Hübschle T., Mütze J., Mühlradt P.F., Korte S., Gerstberger R., Roth J. Pyrexia, anorexia, adipsia, and depressed motor activity in rats during systemic inflammation induce by the Toll-like receptors-2 and -6 agonists MALP-2 and FSL-1. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2006, 290:R180-R187.
9. Knorr C., Hübschle T., Murgott J., Mühlradt P.F., Gesrtberger R., Roth J. Macrophage-activating lipopeptide-2 (MALP-2) induces a localized inflammatory response in rats resulting in activation of brain sites implicated in fever. Brain Res. 2008, 1205:36-46.
10. Matsumura K., Kobayashi S. Signaling the brain in inflammation: the role of endothelial cells. Front. Biosci. 2004, 9:2819-2826.
11. Miller A., Luheshi G.N., Rothwell N.J., Hopkins S.J. Local cytokine induction by LPS in the rat air pouch and its relationship to the febrile response. Am. J. Physiol. Regul. Integr. Comp. Physiol. 1997, 272:R857-R861.
12. Morr M., Takeuchi O., Akira S., Simon M.M., Mühlradt P.F. Differential recognition of structural details of bacterial lipopeptides by toll-like receptors. Eur. J. Immunol. 2002, 32:3337-3347.
13. Nadjar A., Combe C., Layé S., Tridon V., Dantzer R., Amedee T., Parnet P. Nuclear factor κB nuclear translocation as a crucial marker of brain response to interleukin-1. A study in rat and interleukin-1 type I deficient mouse. J. Neurochem. 2003, 87:1024-1036.
14. Nadjar A., Tridon V., May M.J., Ghosh S., Dantzer R., Amedee T., Parnet P. NFkappaB activates in vivo the synthesis of inducible COX-2 in the brain. J. Cereb. Blood Flow Metab. 2005, 1047-1059.
15. Rummel C., Sachot C., Poole S., Luheshi G.N. Circulating interleukin-6 induces fever through a STAT3-linked activation of COX-2 in the brain. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2006, 291:R1316-R1326.
16. Rummel C., Voss T., Matsumura K., Korte S., Gerstberger R., Roth J., Hübschle T. Nuclear STAT3 translocation in guinea pig and rat brain endothelium during systemic challenge with lipopolysaccharide and interleukin-6. J. Comp. Neurol. 2005, 491:1-14.
17. Rummel C., Inoue W., Sachot C., Poole S., Hübschle T., Luheshi G.N. Selective contribution of interleukin-6 and leptin to brain inflammatory signals induced by systemic LPS injection in mice. J. Comp. Neurol. 2008, 511:373-395.
18. Schmidt J., Welsch T., Jäger D., Mühlradt P.F., Büchler M.W., Märten A. Intratumoral injection of the toll-like receptor-2/6 agonist 'macrophage-activating lipopeptide-2' in patients with pancreatic carcinoma: a phase I/II trial. Br. J. Cancer 2007, 97:598-604.
19. Steiner A.A., Ivanov A.J., Serrats J., Hosokawa H., Phayre A.N., Robbins J.R., Roberts J.L., Kobayashi S., Matsumura K., Sawchenko P.E., Romanovsky A.A. Cellular and molecular basis of the initiation of fever. PLoS Biol. 2006, 4:1517-1524.
20. Takemiya T., Matsumura K., Yamagata K. Roles of prostaglandin synthesis in excitotoxic brain diseases. Neurochem. Int. 2007, 51:112-120.
21. Yamagata K., Matsumura K., Inoue W., Shiraki T., Suzuki K., Yasuda S., Sugiura H., Cao C., Watanabe Y., Kobayashi S. Coexpression of microsomal-type prostaglandin E synthase with cyclooxygenase-2 in brain endothelial cells of rats during endotoxin-induced fever. J. Neurosci. 2001, 21:2669-2677.