Fever, sickness behavior, and expression of inflammatory genes in the hypothalamus after systemic and localized subcutaneous stimulation of rats with the toll-like receptor 7 agonist imiquimod

Neuroscience

Volumn 201, Issue , 2012, Pages 166-183

  Damm, J ^a   Wiegand, F ^a   Harden, L M ^a,b   Gerstberger, R ^a   Rummel, C ^a   Roth, J ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

^b UNIVERSITY OF THE WITWATERSRAND   (South Africa)

Author keywords

Cytokines; Fever; Immune to brain signaling; Interferons; Nuclear factor IL6; Toll like receptors

Indexed keywords

CYCLOOXYGENASE 2; ENDOGENOUS PYROGEN; IMIQUIMOD; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; PROSTAGLANDIN E SYNTHASE 1; PROSTAGLANDIN E2; PROTEIN NF IL2; STAT3 PROTEIN; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOASSAY; BLOOD BRAIN BARRIER; BODY TEMPERATURE; CONTROLLED STUDY; DISEASE SEVERITY; DRUG DOSE COMPARISON; DRUG MECHANISM; DRUG POTENCY; ENCEPHALITIS; ENZYME LINKED IMMUNOSORBENT ASSAY; FEVER; FLUID INTAKE; FOOD INTAKE; GENE; GENE EXPRESSION; GENE INDUCTION; HYPOTHALAMUS; ILLNESS BEHAVIOR; IMMUNOHISTOCHEMISTRY; INFLAMMATORY GENE; INNATE IMMUNITY; MALE; MEDIATOR RELEASE; MOTOR ACTIVITY; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN INDUCTION; RAT; REAL TIME POLYMERASE CHAIN REACTION; SEPSIS; TELEMETRY;

ADJUVANTS, IMMUNOLOGIC; AMINOQUINOLINES; ANALYSIS OF VARIANCE; ANIMALS; BODY TEMPERATURE; CYCLOOXYGENASE 2; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRINKING; DRUG ADMINISTRATION ROUTES; EATING; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEVER; GENE EXPRESSION REGULATION; HYPOTHALAMUS; ILLNESS BEHAVIOR; INTRAMOLECULAR OXIDOREDUCTASES; LIVER; MALE; MOTOR ACTIVITY; RATS; SPLEEN; STAT3 TRANSCRIPTION FACTOR; TIME FACTORS; WISTERIA;

EID: 84855557761     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2011.11.013     Document Type: Article

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