Activation of mGlu3 metabotropic glutamate receptors enhances GDNF and GLT-1 formation in the spinal cord and rescues motor neurons in the SOD-1 mouse model of amyotrophic lateral sclerosis

Neurobiology of Disease

Volumn 74, Issue , 2015, Pages 126-136

  Battaglia, Giuseppe ^a   Riozzi, Barbara ^a   Bucci, Domenico ^a   Di Menna, Luisa ^a   Molinaro, Gemma ^a   Pallottino, Simone ^b   Nicoletti, Ferdinando ^a,b   Bruno, Valeria ^a,b  

^a IRCCS NEUROMED   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Amyotrophic lateral sclerosis; GDNF; GLT 1; Metabotropic glutamate receptor; Neurodegeneration; Neuroprotection; SODG93A

Indexed keywords

4 AMINO 2 OXABICYCLO[3.1.0]HEXANE 4,6 DICARBOXYLIC ACID; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; METABOTROPIC RECEPTOR; MONOCLONAL ANTIBODY; NEUROPROTECTIVE AGENT; SODIUM GLUCOSE COTRANSPORTER 1; VESICULAR GLUTAMATE TRANSPORTER 1; AMINO ACID; AMINO ACID RECEPTOR STIMULATING AGENT; COPPER ZINC SUPEROXIDE DISMUTASE; EXCITATORY AMINO ACID TRANSPORTER 2; FUSED HETEROCYCLIC RINGS; GDNF PROTEIN, MOUSE; METABOTROPIC RECEPTOR 2; METABOTROPIC RECEPTOR 3; SLC1A2 PROTEIN, MOUSE; SUPEROXIDE DISMUTASE;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL EXPERIMENT; ARTICLE; ASTROCYTE; CONTINUOUS INFUSION; CONTROLLED STUDY; EMBRYO; EXCITOTOXICITY; IMMUNOHISTOCHEMISTRY; MALE; MORTALITY; MOTONEURON; MOTOR COORDINATION; MOUSE; NONHUMAN; OSMOTIC MINIPUMP; PROTEIN LOCALIZATION; SPINAL CORD; STEREOLOGY; WILD TYPE; ANIMAL; C57BL MOUSE; CELL CULTURE; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECTS; GENETICS; HUMAN; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; TRANSGENIC MOUSE;

AMINO ACIDS; AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; ASTROCYTES; BICYCLO COMPOUNDS, HETEROCYCLIC; CELLS, CULTURED; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID TRANSPORTER 2; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; HUMANS; MALE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MOTOR NEURONS; RECEPTORS, METABOTROPIC GLUTAMATE; SUPEROXIDE DISMUTASE;

EID: 84918838479     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2014.11.012     Document Type: Article

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