Cathepsin D deficiency induces oxidative damage in brain pericytes and impairs the blood-brain barrier

Molecular and Cellular Neuroscience

Volumn 64, Issue , 2015, Pages 51-60

  Okada, Ryo ^a   Wu, Zhou ^a   Zhu, Aiqin ^b   Ni, Junjun ^a   Zhang, Jingqi ^a   Yoshimine, Yoshito ^a   Peters, Christoph ^c   Saftig, Paul ^d   Nakanishi, Hiroshi ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b Institution of Geriatric Qinghai Provincial Hospital   (China)

^c UNIVERSITY OF FREIBURG   (Germany)

^d UNIVERSITY OF KIEL   (Germany)

Author keywords

Brain pericyte; Cathepsin D; Lysosomal storage; Microglia; Reactive oxygen species

Indexed keywords

CATHEPSIN D; FAT DROPLET; PEPSTATIN; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN BLOOD VESSEL; BRAIN CORTEX; BRAIN PERICYTE; CELL VACUOLE; CELL VIABILITY; COMMON CAROTID ARTERY; CONTROLLED STUDY; DNA DAMAGE; ELECTRON MICROSCOPY; ENCEPHALE ISOLE; LYSOSOME STORAGE DISEASE; MICROGLIA; MOUSE; NONHUMAN; OXIDATIVE STRESS; PERICYTE; PERIPHERAL BLOOD MONONUCLEAR CELL; ANIMAL; C57BL MOUSE; CAPILLARY PERMEABILITY; CYTOLOGY; DEFICIENCY; GENETICS; LYSOSOME; METABOLISM; ULTRASTRUCTURE;

MUS; RATTUS;

ANIMALS; BLOOD-BRAIN BARRIER; CAPILLARY PERMEABILITY; CATHEPSIN D; CEREBRAL CORTEX; LYSOSOMES; MICE; MICE, INBRED C57BL; OXIDATIVE STRESS; PERICYTES;

EID: 84918837472     PISSN: 10447431     EISSN: 10959327     Source Type: Journal    
DOI: 10.1016/j.mcn.2014.12.002     Document Type: Article

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