Involvement of lysosomal storage-induced p38 MAP kinase activation in the overproduction of nitric oxide by microglia in cathepsin D-deficient mice

Molecular and Cellular Neuroscience

Volumn 35, Issue 4, 2007, Pages 573-584

  Yamasaki, Ryo ^a,b   Zhang, Jian ^a,c   Koshiishi, Ichiro ^a   Sastradipura Suniarti, Dewi F ^a   Wu, Zhou ^a   Peters, Christoph ^d   Schwake, Michael ^e   Uchiyama, Yasuo ^f   Kira, Jun ichi ^b   Saftig, Paul ^e   Utsumi, Hideo ^a   Nakanishi, Hiroshi ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c SHAOXING UNIVERSITY   (China)

^d UNIVERSITY OF FREIBURG   (Germany)

^e UNIVERSITY OF KIEL   (Germany)

^f OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

AS; CAT 2; Cathepsin D; iNOS; Microglia; NO; p38 MAP kinase

Indexed keywords

ADENOSINE TRIPHOSPHATASE; AMINO ACID TRANSPORTER; CATHEPSIN D; CEROID; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOFUSCIN; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; PEPSTATIN; REACTIVE OXYGEN METABOLITE; SUPEROXIDE;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; CELL PROLIFERATION; CONTROLLED STUDY; DATA ANALYSIS; ENZYME ACTIVATION; ENZYME ACTIVITY; LYSOSOME STORAGE DISEASE; MICROGLIA; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; THALAMUS;

ANIMALS; ARGININOSUCCINATE SYNTHASE; BRAIN; CATHEPSIN D; CATIONIC AMINO ACID TRANSPORTER 2; CELL SHAPE; CELLS, CULTURED; ENZYME ACTIVATION; LYSOSOMES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROGLIA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PEPSTATINS; PROTEASE INHIBITORS; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; TYROSINE;

MUS;

EID: 34547417018     PISSN: 10447431     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mcn.2007.05.002     Document Type: Article

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