Knockdown of Sec8 enhances the binding affinity of c-Jun N-terminal kinase (JNK)-interacting protein 4 for mitogen-activated protein kinase kinase 4 (MKK4) and suppresses the phosphorylation of MKK4, p38, and JNK, thereby inhibiting apoptosis

FEBS Journal

Volumn 281, Issue 23, 2014, Pages 5237-5250

  Tanaka, Toshiaki ^a   Iino, Mitsuyoshi ^a   Goto, Kaoru ^a  

^a YAMAGATA UNIVERSITY   (Japan)

Author keywords

C Jun N terminal kinase (JNK); C Jun Nterminal kinase interacting protein 4 (JIP4); Mitogen activated protein kinase kinase 4 (MKK4); P38; Sec8

Indexed keywords

MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; SEC PROTEIN; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; UNCLASSIFIED DRUG; CYCLOHEXIMIDE; DACTINOMYCIN; EXOC4 PROTEIN, HUMAN; MAP2K4 PROTEIN, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE P38; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SPAG9 PROTEIN, HUMAN; TUMOR NECROSIS FACTOR ALPHA; VESICULAR TRANSPORT PROTEIN;

APOPTOSIS; ARTICLE; BINDING AFFINITY; CANCER CELL; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME REGULATION; EXOCYTOSIS; GENE SILENCING; MAMMAL CELL; MOLECULAR DOCKING; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TRANSACTIVATION; YEAST; DRUG EFFECTS; HEK293 CELL LINE; HELA CELL LINE; HUMAN; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY;

MAMMALIA;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; APOPTOSIS; CYCLOHEXIMIDE; DACTINOMYCIN; HEK293 CELLS; HELA CELLS; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE KINASE 4; MAP KINASE SIGNALING SYSTEM; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; TUMOR NECROSIS FACTOR-ALPHA; VESICULAR TRANSPORT PROTEINS;

EID: 84918813324     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/febs.13063     Document Type: Article

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