Abnormal cortical lysosomal β-hexosaminidase and β-galactosidase activity at post-synaptic sites during Alzheimer's disease progression

International Journal of Biochemistry and Cell Biology

Volumn 58, Issue , 2015, Pages 62-70

  Magini, Alessandro ^a,b   Polchi, Alice ^a   Tozzi, Alessandro ^a,c   Tancini, Brunella ^a   Tantucci, Michela ^a   Urbanelli, Lorena ^a   Borsello, Tiziana ^d   Calabresi, Paolo ^a,c   Emiliani, Carla ^a,e  

^a UNIVERSITY OF PERUGIA   (Italy)

^b UNIVERSITY OF UDINE   (Italy)

^c IRCCS FONDAZIONE SANTA LUCIA   (Italy)

^d MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^e Department of Chemistry   (Italy)

Author keywords

Alzheimers diseasea; Membrane microdomains; Plasma membrane glycohydrolases

Indexed keywords

BETA GALACTOSIDASE; BETA N ACETYLHEXOSAMINIDASE; GANGLIOSIDE GM1; GANGLIOSIDE GM3; POSTSYNAPTIC DENSITY PROTEIN 95; SYNAPTOPHYSIN; GLYCOSIDASE;

ALZHEIMER DISEASE; AMYLOID PLAQUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; DISEASE COURSE; ENZYME ACTIVITY; IMMUNOPRECIPITATION; LYSOSOME; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; SPATIAL MEMORY; SYNAPSE VESICLE; ANIMAL; CELL MEMBRANE; ENZYMOLOGY; GENETICS; HUMAN; IN VITRO STUDY; METABOLISM; TRANSGENIC MOUSE; WESTERN BLOTTING;

ALZHEIMER DISEASE; ANIMALS; BETA-GALACTOSIDASE; BLOTTING, WESTERN; CELL MEMBRANE; GLYCOSIDE HYDROLASES; HUMANS; IN VITRO TECHNIQUES; LYSOSOMES; MEMBRANE MICRODOMAINS; MICE; MICE, TRANSGENIC;

EID: 84918770418     PISSN: 13572725     EISSN: 18785875     Source Type: Journal    
DOI: 10.1016/j.biocel.2014.11.001     Document Type: Article

References (48)

1. E. Adamec, P.S. Mohan, A.M. Cataldo, J.P. Vonsattel, and R.A. Nixon Up-regulation of the lysosomal system in experimental models of neuronal injury: implications for Alzheimer's disease Neuroscience 100 2000 663 675
2. M. Aureli, N. Loberto, V. Chigorno, A. Prinetti, and S. Sonnino Remodeling of sphingolipids by plasma membrane associated enzymes Neurochem Res 36 2011 1636 1644
3. M. Aureli, R. Bassi, N. Loberto, S. Regis, A. Prinetti, and V. Chigorno Cell surface associated glycohydrolases in normal and Gaucher disease fibroblasts J Inherit Metab Dis 35 2012 1081 1091
4. M. Aureli, M. Samarani, N. Loberto, R. Bassi, V. Murdica, and S. Prioni The glycosphingolipid hydrolases in the central nervous system Mol Neurobiol 50 2014 76 87
5. L. Bertram, and R.E. Tanzi Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses Nat Rev Neurosci 9 2008 768 778
6. K. Blennow, M.J. de Leon, and H. Zetterberg Alzheimer's disease Lancet 368 2006 387 403
7. M.M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal Biochem 72 1976 248 254
8. A.M. Cataldo, J.L. Barnett, S.A. Berman, J. Li, S. Quarless, S. Bursztajn, and C. Lippa Gene expression and cellular content of cathepsin D in Alzheimer's disease brain: evidence for early up-regulation of the endosomal-lysosomal system Neuron 14 1995 671 680
9. A.M. Cataldo, D.J. Hamilton, J.L. Barnett, P.A. Paskevich, and R.A. Nixon Properties of the endosomal-lysosomal system in the human central nervous system: disturbances mark most neurons in populations at risk to degenerate in Alzheimer's disease J Neurosci 16 1996 186 199
10. M.A. Chishti, D.S. Yang, C. Janus, A.L. Phinney, P. Horne, and J. Pearson Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695 J Biol Chem 276 2001 21562 21570
11. P.M. Crespo, V.T. Demichelis, and J.L. Daniotti Neobiosynthesis of glycosphingolipids by plasma membrane-associated glycosyltransferases J Biol Chem 285 2010 29179 29190
12. R. Ehehalt, P. Keller, C. Haass, C. Thiele, and K. Simons Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts J Cell Biol 160 2003 113 123
13. C. Emiliani, T. Beccari, A. Tabilio, A. Orlacchio, R. Hosseini, and J.L. Stirling An enzyme with properties similar to those of beta-Nacetylhexosaminidase S is expressed in the promyelocytic cell line HL-60 Biochem J 267 1990 111 117
14. C. Emiliani, S. Martino, J.L. Stirling, and A. Orlacchio Influence of cell differentiation and protein kinase C activation on sub-cellular distribution of beta-N-acetylhexosaminidases of HL60 cells Physiol Chem Phys Med NMR 27 1995 369 376
15. C. Emiliani, L. Urbanelli, L. Racanicchi, A. Orlacchio, G. Pelicci, and S. Sorbi Up-regulation of glycohydrolases in Alzheimer's Disease fibroblasts correlates with Ras activation J Biol Chem 278 2003 38453 38460
16. K.H. Gylys, J.A. Fein, F. Yang, D.J. Wiley, C.A. Miller, and G.M. Cole Synaptic changes in Alzheimer's Disease increased amyloid-β and gliosis in surviving terminals is accompanied by decreased PSD-95 fluorescence Am J Pathol 165 2004 1809 1817
17. O. Isacson, H. Seo, L. Lin, D. Albeck, and A.C. Granholm Alzheimer's disease and Down's syndrome: roles of APP, trophic factors and ACh Trends Neurosci 25 2002 79 84
18. A. Kakio, S.I. Nishimoto, K. Yanagisawa, Y. Kozutsumi, and K. Matsuzaki Cholesterol dependent formation of GM1 ganglioside-bound amyloid beta-protein, an endogenous seed for Alzheimer amyloid J Biol Chem 276 2001 24985 24990
19. A. Magini, S. Mencarelli, B. Tancini, V. Ciccarone, L. Urbanelli, and A. Hasilik Identification and characterization of mature β-hexosaminidases associated with human placenta lysosomal membrane Biosci Rep 28 2008 229 237
20. A. Magini, L. Urbanelli, V. Ciccarone, B. Tancini, M. Polidoro, A. Timperio, and M Fibroblasts from PS1 mutated pre-symptomatic subjects and Alzheimer's disease patients share a unique protein levels profile J Alzheimers Dis 21 2010 431 444
21. A. Magini, A. Polchi, B. Tancini, L. Urbanelli, A. Hasilik, and C. Emiliani Glycohydrolases β-hexosaminidase and β-galactosidase are associated with lipid microdomains of Jurkat T-lymphocytes Biochimie 94 2012 684 694
22. A. Magini, A. Polchi, L. Urbanelli, D. Cesselli, A. Beltrami, and B. Tancini TFEB activation promotes the recruitment of lysosomal glycohydrolases β-hexosaminidase and β-galactosidase to the plasma membrane Biochem Biophys Res Commun 440 2013 251 257
23. A. Magini, A. Polchi, B. Tancini, L. Urbanelli, M. Di Cristina, and R. Mannucci Methods to discriminate the distribution of acidic glycohydrolases between the endosomal-lysosomal systems and the plasma membrane Methods Enzymol 534 2014 25 45
24. D.J. Mahuran Biochemical consequences of mutations causing the GM2 gangliosidoses Biochim Biophys Acta 1455 1999 105 138
25. P.M. Mathews, C.B. Guerra, Y. Jiang, O.M. Grbovic, B.H. Kao, and S.D. Schmidt Alzheimer's disease-related overexpression of the cation-dependent mannose 6-phosphate receptor increases Abeta secretion: role for altered lysosomal hydrolase distribution in beta-amyloidogenesis J Biol Chem 277 2002 5299 5307
26. D.L. Medina, A. Fraldi, V. Bouche, F. Annunziata, G. Mansueto, and C. Spampanato Transcriptional activation of lysosomal exocytosis promotes cellular clearance Dev Cell 21 2011 421 430
27. S. Mencarelli, C. Cavalieri, A. Magini, B. Tancini, L. Basso, and P. Lemansky Identification of plasma membrane associated mature betahexosaminidase A, active towards GM2 ganglioside, in human fibroblasts FEBS Lett 579 2005 5501 5506
28. T. Mizuno, M. Nakata, H. Naiki, M. Michikawa, R. Wang, and C. Haass Cholesterol-dependent generation of a seeding amyloid beta-protein in cell culture J Biol Chem 274 1999 15110 15114
29. R.A. Nixon, and A.M. Cataldo Lysosomal system pathways: genes to neurodegeneration in Alzheimer's disease J Alzheimers Dis 9 2006 277 289
30. R.A. Nixon, P.M. Mathews, and A.M. Cataldo The neuronal endosomal-lysosomal system in Alzheimer's disease J. Alzheimers Dis 3 2001 97 107
31. S. Okada, and J.S. O'Brien Generalized gangliosidosis: beta-galactosidase deficiency Science 160 1968 1002 1004
32. A. Orlacchio, S. Martino, P. Sarchielli, V. Gallai, and C. Emiliani Beta-N-acetylhexosaminidase in peripheral blood lymphocytes and monocytes in the different forms and stages of multiplesclerosis J Neurochem 71 1998 1168 1176
33. M.S. Parihar, and T. Hemnani Alzheimer's disease pathogenesis and therapeutic interventions J Clin Neurosci 11 2004 456 467
34. C. Ploia, X. Antoniou, A. Sclip, V. Grande, D. Cardinetti, and A. Colombo JNK plays a key role in tau hyperphosphorylation in Alzheimer's disease models J Alzheimers Dis 26 2011 315 329
35. M. Sardiello, M. Palmieri, A. di Ronza, D.L. Medina, M. Valenza, and V.A. Gennarino A gene network regulating lysosomal biogenesis and function Science 325 2009 473 477
36. A. Sclip, X. Antoniou, A. Colombo, G.G. Camici, L. Pozzi, and D. Cardinetti c-Jun N-terminal kinase regulates soluble Aβ oligomers and cognitive impairment in AD mouse model J Biol Chem. 286 2011 43871 43880
37. A. Sclip, A. Tozzi, A. Abaza, D. Cardinetti, I. Colombo, and P. Calabresi c-Jun N-terminal kinase has a key role in Alzheimer disease synaptic dysfunction in vivo Cell Death Dis 23 2014 e1019
38. D.J. Selkoe Alzheimer's disease is a synaptic failure Science 298 2002 789 791
39. C. Settembre, C. Di Malta, V.A. Polito, M. Garcia Arencibia, F. Vetrini, and S. Erdin TFEB links autophagy to lysosomal biogenesis Science 332 2011 1429 1433
40. C. Settembre, R. Zoncu, D.L. Medina, F. Vetrini, S. Erdin, and S. Erdin A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB EMBO J 31 2012 1095 1108
41. S. Sonnino, M. Aureli, N. Loberto, V. Chigorno, and A. Prinetti Fine tuning of cell functions through remodelling of glycosphingolipids by plasma membrane-associated glycohydrolases FEBS Lett 584 2010 1914 1922
42. I.Y. Tamboli, H. Hampel, N.T. Tien, K. Tolksdorf, B. Breiden, and P.M. Mathews Sphingolipid storage affects autophagic metabolism of the amyloid precursor protein and promotes Aβ generation J Neurosci 2 2011 1837 1849
43. B. Tancini, A. Magini, L. Latterini, L. Urbanelli, V. Ciccarone, and F. Elisei Occurrence of an anomalous endocytic compartment in fibroblasts from Sandhoff disease patients Mol Cell Biochem 335 2010 273 282
44. B. Tancini, A. Magini, B. Bortot, A. Polchi, L. Urbanelli, and S. Sonnino β-Hexosaminidase over-expression affects lysosomal glycohydrolases expression and glycosphingolipid metabolism in mammalian cells Mol Cell Biochem 363 2012 109 118
45. A. Tozzi, A. Sclip, M. Tantucci, A. de Iure, V. Ghiglieri, and C. Costa Region- and age-dependent reductions of hippocampal long-term potentiation and NMDA to AMPA ratio in a genetic model of Alzheimer's disease Neurobiol Aging 2014 10.1016/j.neurobiolaging.2014.07.002 [Epub ahead of print]
46. L. Urbanelli, C. Emiliani, C. Massini, E. Persichetti, A. Orlacchio, and G. Pelicci Cathepsin D expression is decreased in Alzheimer's disease fibroblasts Neurobiol Aging 29 2008 12 22
47. R. Valaperta, V. Chigorno, L. Basso, A. Prinetti, R. Bresciani, and A. Preti Plasma membrane production of ceramide from ganglioside GM3 in human fibroblasts FASEB J 20 2006 1227 1229
48. S.U. Walkley Pathogenic cascades in lysosomal disease - why so complex? J Inherit Metab Dis 32 2009 181 189