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Volumn 27, Issue 1, 2015, Pages 71-75

The biology of IL-23 and IL-17 and their therapeutic targeting in rheumatic diseases

Author keywords

Interleukin 17; Interleukin 23; Rheumatoid arthritis; Spondyloarthropathy; Systemic lupus erythematosus

Indexed keywords

DISEASE MODIFYING ANTIRHEUMATIC DRUG; INTERLEUKIN 17; INTERLEUKIN 23; TOCILIZUMAB; IMMUNOLOGIC FACTOR;

EID: 84918523128     PISSN: 10408711     EISSN: 15316963     Source Type: Journal    
DOI: 10.1097/BOR.0000000000000132     Document Type: Review
Times cited : (26)

References (53)
  • 1
    • 84906535154 scopus 로고    scopus 로고
    • The IL-23-IL-17 immune axis: From mechanisms to therapeutic testing
    • Gaffen SL, Jain R, Garg AV, Cua DJ. The IL-23-IL-17 immune axis: From mechanisms to therapeutic testing. Nat Rev Immunol 2014; 14:585- 600.
    • (2014) Nat Rev Immunol , vol.14 , pp. 585-600
    • Gaffen, S.L.1    Jain, R.2    Garg, A.V.3    Cua, D.J.4
  • 2
    • 79251471130 scopus 로고    scopus 로고
    • Treatment of rheumatoid arthritis with tumour necrosis factor inhibitors
    • Mewar D, Wilson AG. Treatment of rheumatoid arthritis with tumour necrosis factor inhibitors. Br J Pharmacol 2011; 162:785-791.
    • (2011) Br J Pharmacol , vol.162 , pp. 785-791
    • Mewar, D.1    Wilson, A.G.2
  • 3
    • 0346962972 scopus 로고    scopus 로고
    • Divergent pro- And antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation
    • Murphy CA, Langrish CL, Chen Y, et al. Divergent pro- And antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation. J Exp Med 2003; 198:1951-1957.
    • (2003) J Exp Med , vol.198 , pp. 1951-1957
    • Murphy, C.A.1    Langrish, C.L.2    Chen, Y.3
  • 4
    • 66449133523 scopus 로고    scopus 로고
    • Frequency and phenotype of peripheral blood Th17 cells in ankylosing spondylitis and rheumatoid arthritis
    • Shen H, Goodall JC, Hill Gaston JS. Frequency and phenotype of peripheral blood Th17 cells in ankylosing spondylitis and rheumatoid arthritis. Arthritis Rheum 2009; 60:1647-1656.
    • (2009) Arthritis Rheum , vol.60 , pp. 1647-1656
    • Shen, H.1    Goodall, J.C.2    Hill, G.J.S.3
  • 5
    • 47249125726 scopus 로고    scopus 로고
    • Chronically inflamed human tissues are infiltrated by highly differentiated Th17 lymphocytes
    • Pène J, Chevalier S, Preisser L, et al. Chronically inflamed human tissues are infiltrated by highly differentiated Th17 lymphocytes. J Immunol 2008; 180: 7423-7430.
    • (2008) J Immunol , vol.180 , pp. 7423-7430
    • Pène, J.1    Chevalier, S.2    Preisser, L.3
  • 6
    • 77958558441 scopus 로고    scopus 로고
    • Linking power Doppler ultrasound to the presence of th17 cells in the rheumatoid arthritis joint
    • Gullick NJ, Evans HG, Church LD, et al. Linking power Doppler ultrasound to the presence of th17 cells in the rheumatoid arthritis joint. PLoS One 2010; 5:e12516.
    • (2010) PLoS One , vol.5 , pp. e12516
    • Gullick, N.J.1    Evans, H.G.2    Church, L.D.3
  • 7
    • 0034161692 scopus 로고    scopus 로고
    • High levels of IL-17 in rheumatoid arthritis patients: IL-15 triggers in vitro IL-17 production via cyclosporin A-sensitive mechanism
    • Ziolkowska M, Koc A, Luszczykiewicz G, et al. High levels of IL-17 in rheumatoid arthritis patients: IL-15 triggers in vitro IL-17 production via cyclosporin A-sensitive mechanism. J Immunol 2000; 164:2832-2838.
    • (2000) J Immunol , vol.164 , pp. 2832-2838
    • Ziolkowska, M.1    Koc, A.2    Luszczykiewicz, G.3
  • 8
    • 80053172579 scopus 로고    scopus 로고
    • Mast cells are the main interleukin 17-positive cells in anticitrullinated protein antibody-positive and -negative rheumatoid arthritis and osteoarthritis synovium
    • Suurmond J, Dorjée AL, Boon MR, et al. Mast cells are the main interleukin 17-positive cells in anticitrullinated protein antibody-positive and -negative rheumatoid arthritis and osteoarthritis synovium. Arthritis Res Ther 2011; 13:R150.
    • (2011) Arthritis Res Ther , vol.13 , pp. R150
    • Suurmond, J.1    Dorjée, A.L.2    Boon, M.R.3
  • 9
    • 84891838421 scopus 로고    scopus 로고
    • Pathogenic conversion of Foxp3 T cells into TH17 cells in autoimmune arthritis
    • Komatsu N, Okamoto K, Sawa S, et al. Pathogenic conversion of Foxp3 T cells into TH17 cells in autoimmune arthritis. Nat Med 2014; 20:62-68.
    • (2014) Nat Med , vol.20 , pp. 62-68
    • Komatsu, N.1    Okamoto, K.2    Sawa, S.3
  • 10
    • 84864481289 scopus 로고    scopus 로고
    • Brief report: Inhibition of interleukin-6 function corrects Th17/Treg cell imbalance in patients with rheumatoid arthritis
    • Samson M, Audia S, Janikashvili N, et al. Brief report: Inhibition of interleukin-6 function corrects Th17/Treg cell imbalance in patients with rheumatoid arthritis. Arthritis Rheum 2012; 64:2499-2503.
    • (2012) Arthritis Rheum , vol.64 , pp. 2499-2503
    • Samson, M.1    Audia, S.2    Janikashvili, N.3
  • 11
    • 68949158362 scopus 로고    scopus 로고
    • Human rheumatoid arthritis tissue production of IL-17A drives matrix and cartilage degradation: Synergy with tumour necrosis factor-alpha, Oncostatin M and response to biologic therapies
    • Moran EM, Mullan R, McCormick J, et al. Human rheumatoid arthritis tissue production of IL-17A drives matrix and cartilage degradation: synergy with tumour necrosis factor-alpha, Oncostatin M and response to biologic therapies. Arthritis Res Ther 2009; 11:R113.
    • (2009) Arthritis Res Ther , vol.11 , pp. R113
    • Moran, E.M.1    Mullan, R.2    McCormick, J.3
  • 12
    • 58149242827 scopus 로고    scopus 로고
    • IL-23 promotes osteoclast formation by up-regulation of receptor activator of NF-kappaB (RANK) expression in myeloid precursor cells
    • Chen L, Wei X-Q, Evans B, et al. IL-23 promotes osteoclast formation by up-regulation of receptor activator of NF-kappaB (RANK) expression in myeloid precursor cells. Eur J Immunol 2008; 38:2845-2854.
    • (2008) Eur J Immunol , vol.38 , pp. 2845-2854
    • Chen, L.1    Wei, X.-Q.2    Evans, B.3
  • 13
    • 33751521013 scopus 로고    scopus 로고
    • Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction
    • Sato K, Suematsu A, Okamoto K, et al. Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction. J Exp Med 2006; 203:2673-2682.
    • (2006) J Exp Med , vol.203 , pp. 2673-2682
    • Sato, K.1    Suematsu, A.2    Okamoto, K.3
  • 14
    • 71649102974 scopus 로고    scopus 로고
    • IL-23 induces receptor activator of NF-kappaB ligand expression in fibroblast-like synoviocytes via STAT3 and NF-kappaB signal pathways
    • Li X, Kim K-W, Cho M-L, et al. IL-23 induces receptor activator of NF-kappaB ligand expression in fibroblast-like synoviocytes via STAT3 and NF-kappaB signal pathways. Immunol Lett 2010; 127:100-107.
    • (2010) Immunol Lett , vol.127 , pp. 100-107
    • Li, X.1    Kim, K.-W.2    Cho, M.-L.3
  • 15
    • 49049103008 scopus 로고    scopus 로고
    • IL-23 induces receptor activator of NF-kappaB ligand expression on CD4 T cells and promotes osteoclastogenesis in an autoimmune arthritis model
    • Ju J-H, Cho M-L, Moon Y-M, et al. IL-23 induces receptor activator of NF-kappaB ligand expression on CD4 T cells and promotes osteoclastogenesis in an autoimmune arthritis model. J Immunol 2008; 181:1507-1518.
    • (2008) J Immunol , vol.181 , pp. 1507-1518
    • Ju, J.-H.1    Cho, M.-L.2    Moon, Y.-M.3
  • 16
    • 77951899994 scopus 로고    scopus 로고
    • IL-17 contributes to angiogenesis in rheumatoid arthritis
    • Pickens SR, Volin MV, Mandelin AM, et al. IL-17 contributes to angiogenesis in rheumatoid arthritis. J Immunol 2010; 184:3233-3241.
    • (2010) J Immunol , vol.184 , pp. 3233-3241
    • Pickens, S.R.1    Volin, M.V.2    Mandelin, A.M.3
  • 17
    • 84866074216 scopus 로고    scopus 로고
    • Incomplete response of inflammatory arthritis to TNFa blockade is associated with the Th17 pathway
    • Alzabin S, Abraham SM, Taher TE, et al. Incomplete response of inflammatory arthritis to TNFa blockade is associated with the Th17 pathway. Ann Rheum Dis 2012; 71:1741-1748.
    • (2012) Ann Rheum Dis , vol.71 , pp. 1741-1748
    • Alzabin, S.1    Abraham, S.M.2    Taher, T.E.3
  • 18
    • 84903478179 scopus 로고    scopus 로고
    • A phase II randomized study of subcutaneous ixekizumab, an antiinterleukin-17 monoclonal antibody, in rheumatoid arthritis patients who were naive to biologic agents or had an inadequate response to tumor necrosis factor inhibitors
    • Genovese MC, Greenwald M, Cho C-S, et al. A phase II randomized study of subcutaneous ixekizumab, an antiinterleukin-17 monoclonal antibody, in rheumatoid arthritis patients who were naive to biologic agents or had an inadequate response to tumor necrosis factor inhibitors. Arthritis Rheumatol 2014; 66:1693-1704.
    • (2014) Arthritis Rheumatol , vol.66 , pp. 1693-1704
    • Genovese, M.C.1    Greenwald, M.2    Cho, C.-S.3
  • 19
    • 84867755386 scopus 로고    scopus 로고
    • The potential role of Th17 cells and Th17- related cytokines in the pathogenesis of lupus nephritis
    • Chen DY, Chen YM, Wen MC, et al. The potential role of Th17 cells and Th17- related cytokines in the pathogenesis of lupus nephritis. Lupus 2012; 21:1385-1396.
    • (2012) Lupus , vol.21 , pp. 1385-1396
    • Chen, D.Y.1    Chen, Y.M.2    Wen, M.C.3
  • 20
    • 0024341842 scopus 로고
    • T cell receptor alpha/beta expressing double-negative (CD4-/CD8-) and CD4 T helper cells in humans augment the production of pathogenic anti-DNA autoantibodies associated with lupus nephritis
    • Shivakumar S, Tsokos GC, Datta SK. T cell receptor alpha/beta expressing double-negative (CD4-/CD8-) and CD4 T helper cells in humans augment the production of pathogenic anti-DNA autoantibodies associated with lupus nephritis. J Immunol 1989; 143:103-112.
    • (1989) J Immunol , vol.143 , pp. 103-112
    • Shivakumar, S.1    Tsokos, G.C.2    Datta, S.K.3
  • 21
    • 58849162766 scopus 로고    scopus 로고
    • Expanded double negative T cells in patients with systemic lupus erythematosus produce IL-17 and infiltrate the kidneys
    • Crispín JC, Oukka M, Bayliss G, et al. Expanded double negative T cells in patients with systemic lupus erythematosus produce IL-17 and infiltrate the kidneys. J Immunol 2008; 181:8761-8766.
    • (2008) J Immunol , vol.181 , pp. 8761-8766
    • Crispín, J.C.1    Oukka, M.2    Bayliss, G.3
  • 22
    • 70749113527 scopus 로고    scopus 로고
    • Laser microdissection-based analysis of cytokine balance in the kidneys of patients with lupus nephritis
    • Wang Y, Ito S, Chino Y, et al. Laser microdissection-based analysis of cytokine balance in the kidneys of patients with lupus nephritis. Clin Exp Immunol 2010; 159:1-10.
    • (2010) Clin Exp Immunol , vol.159 , pp. 1-10
    • Wang, Y.1    Ito, S.2    Chino, Y.3
  • 23
    • 84870919913 scopus 로고    scopus 로고
    • Interleukin-17 cytokines are critical in development of fatal lupus glomerulonephritis
    • Pisitkun P, Ha H-L, Wang H, et al. Interleukin-17 cytokines are critical in development of fatal lupus glomerulonephritis. Immunity 2012; 37:1104- 1115.
    • (2012) Immunity , vol.37 , pp. 1104-1115
    • Pisitkun, P.1    Ha, H.-L.2    Wang, H.3
  • 24
    • 84907188637 scopus 로고    scopus 로고
    • Associations between serum interleukin-23 levels and clinical characteristics in patients with systemic lupus erythematosus
    • Du J, Li Z, Shi J, Bi L. Associations between serum interleukin-23 levels and clinical characteristics in patients with systemic lupus erythematosus. J Int Med Res 2014; 42:1123-1130.
    • (2014) J Int Med Res , vol.42 , pp. 1123-1130
    • Du, J.1    Li, Z.2    Shi, J.3    Bi, L.4
  • 25
    • 84865068306 scopus 로고    scopus 로고
    • Gene expression of cytokines (TNF-a, IFN-g), serum profiles of IL-17 and IL-23 in paediatric systemic lupus erythematosus
    • Rana A, Minz RW, Aggarwal R, et al. Gene expression of cytokines (TNF-a, IFN-g), serum profiles of IL-17 and IL-23 in paediatric systemic lupus erythematosus. Lupus 2012; 21:1105-1112.
    • (2012) Lupus , vol.21 , pp. 1105-1112
    • Rana, A.1    Minz, R.W.2    Aggarwal, R.3
  • 26
    • 84860476524 scopus 로고    scopus 로고
    • Enhanced interferon regulatory factor 3 binding to the interleukin-23p19 promoter correlates with enhanced interleukin-23 expression in systemic lupus erythematosus
    • Smith S, Gabhann JN, Higgs R, et al. Enhanced interferon regulatory factor 3 binding to the interleukin-23p19 promoter correlates with enhanced interleukin-23 expression in systemic lupus erythematosus. Arthritis Rheum 2012; 64:1601-1609.
    • (2012) Arthritis Rheum , vol.64 , pp. 1601-1609
    • Smith, S.1    Gabhann, J.N.2    Higgs, R.3
  • 27
    • 78649348525 scopus 로고    scopus 로고
    • Increased interleukin-23 receptor() T cells in peripheral blood mononuclear cells of patients with systemic lupus erythematosus
    • Puwipirom H, Hirankarn N, Sodsai P, et al. Increased interleukin-23 receptor() T cells in peripheral blood mononuclear cells of patients with systemic lupus erythematosus. Arthritis Res Ther 2010; 12:R215.
    • (2010) Arthritis Res Ther , vol.12 , pp. R215
    • Puwipirom, H.1    Hirankarn, N.2    Sodsai, P.3
  • 28
    • 77957867731 scopus 로고    scopus 로고
    • The relation of interleukin 17 (IL-17) and IL-23 to Th1/Th2 cytokines and disease activity in systemic lupus erythematosus
    • Mok MY, Wu HJ, Lo Y, Lau CS. The relation of interleukin 17 (IL-17) and IL-23 to Th1/Th2 cytokines and disease activity in systemic lupus erythematosus. J Rheumatol 2010; 37:2046-2052.
    • (2010) J Rheumatol , vol.37 , pp. 2046-2052
    • Mok, M.Y.1    Wu, H.J.2    Lo, Y.3    Lau, C.S.4
  • 29
    • 84878013708 scopus 로고    scopus 로고
    • Th22, but not Th17 might be a good index to predict the tissue involvement of systemic lupus erythematosus
    • Yang X-Y, Wang H-Y, Zhao X-Y, et al. Th22, but not Th17 might be a good index to predict the tissue involvement of systemic lupus erythematosus. J Clin Immunol 2013; 33:767-774.
    • (2013) J Clin Immunol , vol.33 , pp. 767-774
    • Yang, X.-Y.1    Wang, H.-Y.2    Zhao, X.-Y.3
  • 30
    • 84882529537 scopus 로고    scopus 로고
    • Clinical associations of serum interleukin- 17 in systemic lupus erythematosus
    • Vincent FB, Northcott M, Hoi A, et al. Clinical associations of serum interleukin- 17 in systemic lupus erythematosus. Arthritis Res Ther 2013; 15:R97.
    • (2013) Arthritis Res Ther , vol.15 , pp. R97
    • Vincent, F.B.1    Northcott, M.2    Hoi, A.3
  • 31
    • 70349238893 scopus 로고    scopus 로고
    • The role of IL-23/IL-17 axis in lupus nephritis
    • Zhang Z, Kyttaris VC, Tsokos GC. The role of IL-23/IL-17 axis in lupus nephritis. J Immunol 2009; 183:3160-3169.
    • (2009) J Immunol , vol.183 , pp. 3160-3169
    • Zhang, Z.1    Kyttaris, V.C.2    Tsokos, G.C.3
  • 32
    • 77953196382 scopus 로고    scopus 로고
    • Cutting edge: IL-23 receptor deficiency prevents the development of lupus nephritis in C57BL/6-lpr/lpr mice
    • Kyttaris VC, Zhang Z, Kuchroo VK, et al. Cutting edge: IL-23 receptor deficiency prevents the development of lupus nephritis in C57BL/6-lpr/lpr mice. J Immunol 2010; 184:4605-4609.
    • (2010) J Immunol , vol.184 , pp. 4605-4609
    • Kyttaris, V.C.1    Zhang, Z.2    Kuchroo, V.K.3
  • 33
    • 84879407426 scopus 로고    scopus 로고
    • Treatment with anti-interleukin 23 antibody ameliorates disease in lupus-prone mice
    • Kyttaris VC, Kampagianni O, Tsokos GC. Treatment with anti-interleukin 23 antibody ameliorates disease in lupus-prone mice. Biomed Res Int 2013; 2013:861028.
    • (2013) Biomed Res Int , vol.2013 , pp. 861028
    • Kyttaris, V.C.1    Kampagianni, O.2    Tsokos, G.C.3
  • 34
    • 68149179247 scopus 로고    scopus 로고
    • Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by dysregulating the IL-23-Th17 pathway
    • Espinosa A, Dardalhon V, Brauner S, et al. Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by dysregulating the IL-23-Th17 pathway. J Exp Med 2009; 206:1661-1671.
    • (2009) J Exp Med , vol.206 , pp. 1661-1671
    • Espinosa, A.1    Dardalhon, V.2    Brauner, S.3
  • 35
    • 84901619105 scopus 로고    scopus 로고
    • Piperlongumine alleviates lupus nephritis in MRLFas( lpr) mice by regulating the frequency of Th17 and regulatory T cells
    • Yao L, Chen H-P, Ma Q. Piperlongumine alleviates lupus nephritis in MRLFas( lpr) mice by regulating the frequency of Th17 and regulatory T cells. Immunol Lett 2014; 161:76-80.
    • (2014) Immunol Lett , vol.161 , pp. 76-80
    • Yao, L.1    Chen, H.-P.2    Ma, Q.3
  • 36
    • 84937511954 scopus 로고    scopus 로고
    • Detection of dynamic frequencies of Th17 cells and their associations with clinical parameters in patients with systemic lupus erythematosus receiving standard therapy
    • Wen Z, Xu L, Xu W, Xiong S. Detection of dynamic frequencies of Th17 cells and their associations with clinical parameters in patients with systemic lupus erythematosus receiving standard therapy. Clin Rheumatol 2014; 33:1451- 1458.
    • (2014) Clin Rheumatol , vol.33 , pp. 1451-1458
    • Wen, Z.1    Xu, L.2    Xu, W.3    Xiong, S.4
  • 37
    • 35748981184 scopus 로고    scopus 로고
    • Association scan of 14, 500 nonsynonymous SNPs in four diseases identifies autoimmunity variants
    • Wellcome Trust Case Control Consortium, Australo-Anglo-American Spondylitis Consortium (TASC
    • Wellcome Trust Case Control Consortium, Australo-Anglo-American Spondylitis Consortium (TASC). Burton PR, Clayton DG, Cardon LR, et al. Association scan of 14, 500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet 2007; 39:1329-1337.
    • (2007) Nat Genet , vol.39 , pp. 1329-1337
    • Burton, P.R.1    Clayton, D.G.2    Cardon, L.R.3
  • 38
    • 33845340501 scopus 로고    scopus 로고
    • A genome-wide association study identifies IL23R as an inflammatory bowel disease gene
    • Duerr R, Taylor K, Brant S, et al. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science 2006; 314:1461- 1463.
    • (2006) Science , vol.314 , pp. 1461-1463
    • Duerr, R.1    Taylor, K.2    Brant, S.3
  • 39
    • 34547774225 scopus 로고    scopus 로고
    • Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis
    • Capon F, Di Meglio P, Szaub J, et al. Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis. Hum Genet 2007; 122:201-206.
    • (2007) Hum Genet , vol.122 , pp. 201-206
    • Capon, F.1    Di Meglio, P.2    Szaub, J.3
  • 40
    • 33846608131 scopus 로고    scopus 로고
    • A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes
    • Cargill M, Schrodi SJ, Chang M, et al. A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes. Am J Hum Genet 2007; 80:273-290.
    • (2007) Am J Hum Genet , vol.80 , pp. 273-290
    • Cargill, M.1    Schrodi, S.J.2    Chang, M.3
  • 41
    • 59149106117 scopus 로고    scopus 로고
    • Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways
    • Nair RP, Duffin KC, Helms C, et al. Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. Nat Genet 2009; 41:199- 204.
    • (2009) Nat Genet , vol.41 , pp. 199-204
    • Nair, R.P.1    Duffin, K.C.2    Helms, C.3
  • 42
    • 78650706586 scopus 로고    scopus 로고
    • Cutting edge: A critical functional role for IL-23 in psoriasis
    • Tonel G, Conrad C, Laggner U, et al. Cutting edge: A critical functional role for IL-23 in psoriasis. J Immunol 2010; 185:5688-5691.
    • (2010) J Immunol , vol.185 , pp. 5688-5691
    • Tonel, G.1    Conrad, C.2    Laggner, U.3
  • 43
    • 31144441631 scopus 로고    scopus 로고
    • In vitro and in situ expression of IL-23 by keratinocytes in healthy skin and psoriasis lesions: Enhanced expression in psoriatic, skin
    • Piskin G, Sylva-Steenland RMR, Bos JD, Teunissen MBM. In vitro and in situ expression of IL-23 by keratinocytes in healthy skin and psoriasis lesions: enhanced expression in psoriatic skin. J Immunol 2006; 176:1908-1915.
    • (2006) J Immunol , vol.176 , pp. 1908-1915
    • Piskin, G.1    Sylva-Steenland, R.M.R.2    Bos, J.D.3    Teunissen, M.B.M.4
  • 44
    • 0347285359 scopus 로고    scopus 로고
    • Increased expression of interleukin 23 p19 and p40 in lesional skin of patients with psoriasis vulgaris
    • Lee E, Trepicchio WL, Oestreicher JL, et al. Increased expression of interleukin 23 p19 and p40 in lesional skin of patients with psoriasis vulgaris. J Exp Med 2004; 199:125-130.
    • (2004) J Exp Med , vol.199 , pp. 125-130
    • Lee, E.1    Trepicchio, W.L.2    Oestreicher, J.L.3
  • 45
    • 0028823453 scopus 로고
    • The evolution of spondyloarthropathies in relation to gut histology. II. Histological aspects
    • Mielants H, Veys EM, Cuvelier C, et al. The evolution of spondyloarthropathies in relation to gut histology. II. Histological aspects. J Rheumatol 1995; 22:2273-2278.
    • (1995) J Rheumatol , vol.22 , pp. 2273-2278
    • Mielants, H.1    Veys, E.M.2    Cuvelier, C.3
  • 46
    • 65249152431 scopus 로고    scopus 로고
    • Overexpression of interleukin-23, but not interleukin-17, as an immunologic signature of subclinical intestinal inflammation in ankylosing spondylitis
    • Ciccia F, Bombardieri M, Principato A, et al. Overexpression of interleukin-23, but not interleukin-17, as an immunologic signature of subclinical intestinal inflammation in ankylosing spondylitis. Arthritis Rheum 2009; 60:955-965.
    • (2009) Arthritis Rheum , vol.60 , pp. 955-965
    • Ciccia, F.1    Bombardieri, M.2    Principato, A.3
  • 48
    • 79951835541 scopus 로고    scopus 로고
    • Th17 cells expressing KIR3DL2 and responsive to HLA-B27 homodimers are increased in ankylosing spondylitis
    • Bowness P, Ridley A, Shaw J, et al. Th17 cells expressing KIR3DL2 and responsive to HLA-B27 homodimers are increased in ankylosing spondylitis. J Immunol 2011; 186:2672-2680.
    • (2011) J Immunol , vol.186 , pp. 2672-2680
    • Bowness, P.1    Ridley, A.2    Shaw, J.3
  • 49
    • 78049271424 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress-induced transcription factor, CHOP, is crucial for dendritic cell IL-23 expression
    • Goodall JC, Wu C, Zhang Y, et al. Endoplasmic reticulum stress-induced transcription factor, CHOP, is crucial for dendritic cell IL-23 expression. Proc Natl Acad Sci U S A 2010; 107:17698-17703.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 17698-17703
    • Goodall, J.C.1    Wu, C.2    Zhang, Y.3
  • 50
    • 84863697312 scopus 로고    scopus 로고
    • IL-23 induces spondyloarthropathy by acting on ROR-GT CD3CD4-CD8- entheseal resident t cells
    • Sherlock JP, Joyce-Shaikh B, Turner SP, et al. IL-23 induces spondyloarthropathy by acting on ROR-gt CD3CD4-CD8- entheseal resident T cells. Nat Med 2012; 18:1069-1076.
    • (2012) Nat Med , vol.18 , pp. 1069-1076
    • Sherlock, J.P.1    Joyce-Shaikh, B.2    Turner, S.P.3
  • 51
    • 84883134297 scopus 로고    scopus 로고
    • Efficacy and safety of ustekinumab in patients with active psoriatic arthritis: 1 year results of the phase 3, multicentre, double-blind, placebo-controlled PSUMMIT 1 trial
    • McInnes IB, Kavanaugh A, Gottlieb AB, et al. Efficacy and safety of ustekinumab in patients with active psoriatic arthritis: 1 year results of the phase 3, multicentre, double-blind, placebo-controlled PSUMMIT 1 trial. Lancet 2013; 382:780-789.
    • (2013) Lancet , vol.382 , pp. 780-789
    • McInnes, I.B.1    Kavanaugh, A.2    Gottlieb, A.B.3
  • 52
    • 84899991797 scopus 로고    scopus 로고
    • Efficacy and safety of the anti-IL-12/23 p40 monoclonal antibody, ustekinumab, in patients with active psoriatic arthritis despite conventional nonbiological and biological antitumour necrosis factor therapy: 6-month and 1-year results of the phase 3, multicentre, double-blind, placebo-controlled, randomised psummit 2 trial
    • Ritchlin C, Rahman P, Kavanaugh A, et al. Efficacy and safety of the anti-IL-12/23 p40 monoclonal antibody, ustekinumab, in patients with active psoriatic arthritis despite conventional nonbiological and biological antitumour necrosis factor therapy: 6-month and 1-year results of the phase 3, multicentre, double-blind, placebo-controlled, randomised PSUMMIT 2 trial. Ann Rheum Dis 2014; 73:990-999.
    • (2014) Ann Rheum Dis , vol.73 , pp. 990-999
    • Ritchlin, C.1    Rahman, P.2    Kavanaugh, A.3
  • 53
    • 0033638507 scopus 로고    scopus 로고
    • Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from il-12
    • Oppmann B, Lesley R, Blom B, et al. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 2000; 13:715-725.
    • (2000) Immunity , vol.13 , pp. 715-725
    • Oppmann, B.1    Lesley, R.2    Blom, B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.