Analysis of subpocket selectivity and identification of potent selective inhibitors for matriptase and matriptase-2

Journal of Medicinal Chemistry

Volumn 57, Issue 23, 2014, Pages 10198-10204

  Duchêne, Dominic ^a   Colombo, Eloïc ^a   Désilets, Antoine ^a   Boudreault, Pierre Luc ^a   Leduc, Richard ^a   Marsault, Eric ^a   Najmanovich, Rafael ^a  

^a UNIVERSITY OF SHERBROOKE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

HEPCIDIN; MATRIPTASE; MATRIPTASE 2; PEPTIDOMIMETIC AGENT; SERINE PROTEINASE INHIBITOR; UNCLASSIFIED DRUG; MEMBRANE PROTEIN; SERINE PROTEINASE;

ARTICLE; CHEMICAL ANALYSIS; DRUG SCREENING; DRUG SYNTHESIS; ENTROPY; ENZYME INHIBITION; GENETIC ALGORITHM; HOMEOSTASIS; HYDROPHOBICITY; MOLECULAR DOCKING; MOLECULAR RECOGNITION; PREDICTION; SIMULATION; VIRUS REPLICATION; ANTAGONISTS AND INHIBITORS; CHEMISTRY; ENZYME ACTIVE SITE; HUMAN; METABOLISM; PROTEIN TERTIARY STRUCTURE; STRUCTURE ACTIVITY RELATION;

CATALYTIC DOMAIN; HUMANS; MEMBRANE PROTEINS; MOLECULAR DOCKING SIMULATION; PROTEIN STRUCTURE, TERTIARY; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84918520086     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm5015633     Document Type: Article

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