Covalent docking of large libraries for the discovery of chemical probes

Nature chemical biology

Volumn 10, Issue 12, 2014, Pages 1066-1072

  London, Nir ^a   Miller, Rand M ^b   Krishnan, Shyam ^a   Uchida, Kenji ^a   Irwin, John J ^a   Eidam, Oliv ^c   Gibold, Lucie ^b   Cimermančič, Peter ^a   Bonnet, Richard ^a   Shoichet, Brian K ^b   Taunton, Jack ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPC BETA-LACTAMASES; BACTERIAL PROTEIN; BETA LACTAMASE; BETA LACTAMASE INHIBITOR; CYSTEINE; JAK3 PROTEIN, HUMAN; JANUS KINASE 3; LIGAND; MITOGEN AND STRESS-ACTIVATED PROTEIN KINASE 1; MOLECULAR LIBRARY; MOLECULAR PROBE; PROTEIN BINDING; PROTEIN KINASE INHIBITOR; RECOMBINANT PROTEIN; RIBOSOMAL PROTEIN S6 KINASE, 90KDA, POLYPEPTIDE 3; S6 KINASE; SERINE;

ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICAL PHENOMENA; CHEMISTRY; COS 1 CELL LINE; DRUG DEVELOPMENT; DRUG EFFECTS; ENZYMOLOGY; GENETICS; GRAM NEGATIVE BACTERIUM; GROWTH, DEVELOPMENT AND AGING; HUMAN; METABOLISM; MOLECULAR DOCKING; MOLECULAR LIBRARY; MOLECULAR PROBE; PHARMACOLOGY;

ANIMALS; BACTERIAL PROTEINS; BETA-LACTAMASE INHIBITORS; BETA-LACTAMASES; COS CELLS; CYSTEINE; DRUG DISCOVERY; GRAM-NEGATIVE BACTERIA; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; JANUS KINASE 3; LIGANDS; MOLECULAR DOCKING SIMULATION; MOLECULAR PROBES; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; RECOMBINANT PROTEINS; RIBOSOMAL PROTEIN S6 KINASES, 90-KDA; SERINE; SMALL MOLECULE LIBRARIES;

EID: 84913544750     PISSN: None     EISSN: 15524469     Source Type: Journal    
DOI: 10.1038/nchembio.1666     Document Type: Article

References (0)