N-glycosylation is required for matriptase-2 autoactivation and ectodomain shedding

Journal of Biological Chemistry

Volumn 289, Issue 28, 2014, Pages 19500-19507

  Jiang, Jiang ^a   Yang, Jianfeng ^a   Feng, Ping ^a   Zuo, Bin ^a   Dong, Ningzheng ^a   Wu, Qingyu ^a,b   He, Yang ^a  

^a SOOCHOW UNIVERSITY   (China)

^b LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CELL MEMBRANES;

CELL SURFACE EXPRESSION; CELL SURFACE PROTEINS; CONDITIONED MEDIUM; ECTODOMAIN SHEDDING; INACTIVE MUTANTS; IRON HOMEOSTASIS; N-GLYCOSYLATION SITES; ZYMOGEN ACTIVATION;

CHEMICAL ACTIVATION;

ENZYME PRECURSOR; MATRIPTASE; MATRIPTASE 2; UNCLASSIFIED DRUG;

ARTICLE; BEL 7402 CELL LINE; CATALYSIS; CELL SURFACE; CONTROLLED STUDY; ECTODOMAIN SHEDDING; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME GLYCOSYLATION; ENZYME LOCALIZATION; ENZYME MODIFICATION; ENZYME REGULATION; HEK293 CELL LINE; HEPATOCELLULAR CARCINOMA CELL LINE; HUMAN; HUMAN CELL; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; QGY 7703 CELL LINE; SMMC 7721 CELL LINE;

GLYCOSYLATION; IRON METABOLISM; PROTEOLYTIC ENZYME; SERINE PROTEASE; SHEDDING;

AMINO ACID SUBSTITUTION; CELL LINE, TUMOR; ENZYME ACTIVATION; ENZYME PRECURSORS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLYCOSYLATION; HEK293 CELLS; HUMANS; LIVER; MEMBRANE PROTEINS; MUTATION, MISSENSE; SERINE ENDOPEPTIDASES;

EID: 84904191223     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.555110     Document Type: Article

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