CUL4B impedes stress-induced cellular senescence by dampening a p53-reactive oxygen species positive feedback loop

Free Radical Biology and Medicine

Volumn 79, Issue , 2015, Pages 1-13

  Wei, Zhao ^a   Guo, Haiyang ^a   Liu, Zhaojian ^a   Zhang, Xiyu ^a   Liu, Qiao ^a   Qian, Yanyan ^a   Gong, Yaoqin ^a   Shao, Changshun ^a,b  

^a Shandong Key Laboratory of Digital Human and Clinical Anatomy   (China)

^b Life Sciences Building Rutgers University   (United States)

Author keywords

CUL4B; Feedbackloop; p53; Reactiveoxygenspecies; Senescence; Ubiquitination

Indexed keywords

BROXURIDINE; CULLIN; CULLIN 4B; PROTEIN P53; REACTIVE OXYGEN METABOLITE; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; CUL4B PROTEIN, HUMAN; HYDROGEN PEROXIDE;

ANIMAL CELL; ARTICLE; CELL AGING; CELL CYCLE ARREST; CELL PROLIFERATION; CELL STRESS; COLONY FORMATION; CONTROLLED STUDY; DNA REPLICATION; FEEDBACK SYSTEM; IMMUNOPRECIPITATION; MOUSE; NONHUMAN; OSTEOSARCOMA CELL; OXIDATIVE STRESS; PLASMID; POSITIVE FEEDBACK; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SENESCENCE; UBIQUITINATION; WESTERN BLOTTING; WILD TYPE; ANIMAL; GENETICS; HUMAN; KNOCKOUT MOUSE; MALE; METABOLISM; PHYSIOLOGY;

ANIMALS; CELL AGING; CULLIN PROTEINS; HUMANS; HYDROGEN PEROXIDE; MALE; MICE; MICE, KNOCKOUT; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITINATION;

EID: 84918519759     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2014.11.010     Document Type: Article

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