Chemokine receptor CXCR2 is transactivated by p53 and induces p38-mediated cellular senescence in response to DNA damage

Aging Cell

Volumn 12, Issue 6, 2013, Pages 1110-1121

  Guo, Haiyang ^a   Liu, Zhaojian ^a   Xu, Bing ^a   Hu, Huili ^a   Wei, Zhao ^a   Liu, Qiao ^a   Zhang, Xiyu ^a   Ding, Xuebin ^a   Wang, Yu ^a   Zhao, Minnan ^a   Gong, Yaoqin ^a   Shao, Changshun ^a,b  

^a SHANDONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b RUTGERS UNIVERSITY   (United States)

Author keywords

CXCR2; P38; P53; Senescence; Transcriptional activation

Indexed keywords

1 (2 BROMOPHENYL) 3 (2 HYDROXY 4 NITROPHENYL)UREA; 3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; APHIDICOLIN; CHEMOKINE RECEPTOR CXCR2; DOXORUBICIN; HYDROXYUREA; INTERLEUKIN 6; INTERLEUKIN 8; MITOGEN ACTIVATED PROTEIN KINASE P38; NUTLIN 3; PROTEIN P21; PROTEIN P53;

ARTICLE; CELL AGING; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; CYTOKINE RESPONSE; DNA DAMAGE; GENE SILENCING; HUMAN; HUMAN CELL; IONIZING RADIATION; OXIDATIVE STRESS; PHENOTYPE; PRIORITY JOURNAL; SENESCENCE; TRANSACTIVATION; UPREGULATION;

MAMMALIA;

CXCR2; P38; P53; SENESCENCE; TRANSCRIPTIONAL ACTIVATION;

ANIMALS; BASE SEQUENCE; CELL AGING; CELL LINE, TUMOR; DNA DAMAGE; ENZYME ACTIVATION; MAP KINASE SIGNALING SYSTEM; MICE; MOLECULAR SEQUENCE DATA; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHENOTYPE; RADIATION, IONIZING; RECEPTORS, INTERLEUKIN-8B; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

EID: 84888132393     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/acel.12138     Document Type: Article

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