Dicarba analogues of α-conotoxin RgIA. Structure, stability, and activity at potential pain targets

Journal of Medicinal Chemistry

Volumn 57, Issue 23, 2014, Pages 9933-9944

  Chhabra, Sandeep ^a   Belgi, Alessia ^a   Bartels, Peter ^b   Van Lierop, Bianca J ^a   Robinson, Samuel D ^a   Kompella, Shiva N ^b   Hung, Andrew ^b   Callaghan, Brid P ^b   Adams, David J ^b   Robinson, Andrea J ^a   Norton, Raymond S ^a  

^a MONASH UNIVERSITY   (Australia)

^b RMIT UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID B RECEPTOR; ALLYLGLYCINE; ALPHA CONOTOXIN RGIA; CALCIUM CHANNEL N TYPE; NICOTINIC RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG; ANALGESIC AGENT; CONOTOXIN; CONOTOXIN ALPHA-RGIA, CONUS REGIUS; NICOTINIC RECEPTOR;

ANALGESIA; ANALGESIC ACTIVITY; ARTICLE; DEPOLARIZATION; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROPHYSIOLOGY; HEK293 CELL LINE; HETERONUCLEAR SINGLE QUANTUM COHERENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYBRIDIZATION; MICROWAVE IRRADIATION; MOLECULAR DYNAMICS; NUCLEAR OVERHAUSER EFFECT; PEPTIDE SYNTHESIS; PROTON NUCLEAR MAGNETIC RESONANCE; RING CLOSING METATHESIS; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; DRUG EFFECTS; HUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RAT;

AMINO ACID SEQUENCE; ANALGESICS; ANIMALS; CALCIUM CHANNELS, N-TYPE; CONOTOXINS; HEK293 CELLS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR DYNAMICS SIMULATION; RATS; RECEPTORS, NICOTINIC;

EID: 84918492290     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm501126u     Document Type: Article

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