Analgesic α-conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in rat sensory neurons via GABAB receptor activation

Journal of Neuroscience

Volumn 28, Issue 43, 2008, Pages 10943-10951

  Callaghan, Brid ^a   Haythornthwaite, Alison ^a   Berecki, Géza ^a   Clark, Richard J ^a   Craik, David J ^a   Adams, David J ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Analgesia; Conotoxins; Dorsal root ganglion; G protein; GABAB receptor; N type calcium channel

Indexed keywords

3 [[1 (3,4 DICHLOROPHENYL)ETHYL]AMINO] 2 HYDROXY PROPYL][3,4] CYCLOHEXYLMETHYL) PHOSPHINIC ACID HYDROCHLORIDE 3[[1 (3,4 DICHLOROPHENYL) ETHYL]AMINO 2 HYDROXYPROPYL][PHENYLMETHYL]PHOSPHINIC ACID; 4 AMINOBUTYRIC ACID B RECEPTOR; 4 AMINOBUTYRIC ACID B RECEPTOR BLOCKING AGENT; ALPHA CONOTOXIN RG1A; ALPHA CONOTOXIN VC1.1; CALCIUM CHANNEL N TYPE; CALCIUM ION; CONOTOXIN; G PROTEIN COUPLED RECEPTOR; OMEGA CONOTOXIN; PERTUSSIS TOXIN; PHACLOFEN; PROTEIN KINASE; PROTEIN KINASE SRC; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG; VOLTAGE GATED CALCIUM CHANNEL; 4 AMINOBUTYRIC ACID RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; ALPHA-CONOTOXIN VC1.1; ANALGESIC AGENT; BACLOFEN; BARIUM; BENZYL[3 [[1 (3,4 DICHLOROPHENYL)ETHYL]AMINO] 2 HYDROXYPROPYL]PHOSPHINIC ACID; CALCIUM CHANNEL BLOCKING AGENT; CONOTOXIN ALPHA RGIA, CONUS REGIUS; CONOTOXIN ALPHA-RGIA, CONUS REGIUS; DRUG DERIVATIVE; PHOSPHINIC ACID DERIVATIVE; PROPANOLAMINE DERIVATIVE;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; ELECTRIC POTENTIAL; INCUBATION TIME; NEUROPATHIC PAIN; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SENSORY NERVE CELL; SPINAL GANGLION; XENOPUS; ANIMAL; CELL CULTURE; CELL MEMBRANE POTENTIAL; CYTOLOGY; DRUG EFFECT; ELECTROSTIMULATION; METHODOLOGY; NEWBORN; PATCH CLAMP; PHYSIOLOGY; RADIATION EXPOSURE; RADIATION RESPONSE; SENSORY RECEPTOR; WISTAR RAT;

ANALGESICS; ANIMALS; ANIMALS, NEWBORN; BACLOFEN; BARIUM; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, N-TYPE; CELLS, CULTURED; CONOTOXINS; DOSE-RESPONSE RELATIONSHIP, RADIATION; ELECTRIC STIMULATION; GABA ANTAGONISTS; GANGLIA, SPINAL; MEMBRANE POTENTIALS; OMEGA-CONOTOXINS; PATCH-CLAMP TECHNIQUES; PERTUSSIS TOXIN; PHOSPHINIC ACIDS; PROPANOLAMINES; RATS; RATS, WISTAR; RECEPTORS, GABA; SENSORY RECEPTOR CELLS;

EID: 58149172098     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3594-08.2008     Document Type: Article

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